Dihydropyrimidine compound and application in medicine
The invention relates to a dihydropyrimidine compound and an application of the dihydropyrimidine compound as a medicine, particularly to an application of the dihydropyrimidine compound as a medicinefor treating and preventing hepatitis B, specifically to a compound represented by a general formula...
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| creator | LI JING YAN GUANGHUA WANG MENG LAI QINGYING WANG HENG CHEN YUNFU LIU XINCHANG REN QINGYUN GUO LIANGHONG LEI DOUXING WANG XING'AN ZHANG YINGJUN YIN LIHUA |
| description | The invention relates to a dihydropyrimidine compound and an application of the dihydropyrimidine compound as a medicine, particularly to an application of the dihydropyrimidine compound as a medicinefor treating and preventing hepatitis B, specifically to a compound represented by a general formula (I) or (Ia) or a stereoisomer, a tautomer, a nitrogen oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein each variable is defined in the specification. The invention also relates to application of the compound represented by the general formula (I) or(Ia) or the stereoisomer, tautomer, nitrogen oxide, solvate, metabolite and pharmaceutically acceptable salt thereof as a medicine, particularly to application of the compound as a medicine for treating and preventing hepatitis B.
本发明涉及一种二氢嘧啶类化合物及其作为药物的应用，尤其是作为治疗和预防乙型肝炎的药物的应用。具体地说，本发明涉及通式(I)或(Ia)所示的化合物或其立体异构体、互变异构体、氮氧化物、溶剂化物、代谢产物、药学上可接受的盐或它的前药，其中各变量如说明书所定义。本发明还涉及通式(I)或(Ia)所示的化合物或其立体异构体、互变异构体、氮氧化物、溶剂化物、代谢产物、药学上可接受的盐作为药物的用途， |
| format | Patent |
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本发明涉及一种二氢嘧啶类化合物及其作为药物的应用，尤其是作为治疗和预防乙型肝炎的药物的应用。具体地说，本发明涉及通式(I)或(Ia)所示的化合物或其立体异构体、互变异构体、氮氧化物、溶剂化物、代谢产物、药学上可接受的盐或它的前药，其中各变量如说明书所定义。本发明还涉及通式(I)或(Ia)所示的化合物或其立体异构体、互变异构体、氮氧化物、溶剂化物、代谢产物、药学上可接受的盐作为药物的用途，</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20201027&DB=EPODOC&CC=CN&NR=111825676A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20201027&DB=EPODOC&CC=CN&NR=111825676A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LI JING</creatorcontrib><creatorcontrib>YAN GUANGHUA</creatorcontrib><creatorcontrib>WANG MENG</creatorcontrib><creatorcontrib>LAI QINGYING</creatorcontrib><creatorcontrib>WANG HENG</creatorcontrib><creatorcontrib>CHEN YUNFU</creatorcontrib><creatorcontrib>LIU XINCHANG</creatorcontrib><creatorcontrib>REN QINGYUN</creatorcontrib><creatorcontrib>GUO LIANGHONG</creatorcontrib><creatorcontrib>LEI DOUXING</creatorcontrib><creatorcontrib>WANG XING'AN</creatorcontrib><creatorcontrib>ZHANG YINGJUN</creatorcontrib><creatorcontrib>YIN LIHUA</creatorcontrib><title>Dihydropyrimidine compound and application in medicine</title><description>The invention relates to a dihydropyrimidine compound and an application of the dihydropyrimidine compound as a medicine, particularly to an application of the dihydropyrimidine compound as a medicinefor treating and preventing hepatitis B, specifically to a compound represented by a general formula (I) or (Ia) or a stereoisomer, a tautomer, a nitrogen oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein each variable is defined in the specification. The invention also relates to application of the compound represented by the general formula (I) or(Ia) or the stereoisomer, tautomer, nitrogen oxide, solvate, metabolite and pharmaceutically acceptable salt thereof as a medicine, particularly to application of the compound as a medicine for treating and preventing hepatitis B.
本发明涉及一种二氢嘧啶类化合物及其作为药物的应用，尤其是作为治疗和预防乙型肝炎的药物的应用。具体地说，本发明涉及通式(I)或(Ia)所示的化合物或其立体异构体、互变异构体、氮氧化物、溶剂化物、代谢产物、药学上可接受的盐或它的前药，其中各变量如说明书所定义。本发明还涉及通式(I)或(Ia)所示的化合物或其立体异构体、互变异构体、氮氧化物、溶剂化物、代谢产物、药学上可接受的盐作为药物的用途，</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDBzycyoTCnKL6gsyszNTMnMS1VIzs8tyC_NS1FIBOGCgpzM5MSSzPw8hcw8hdzUlMxkoCIeBta0xJziVF4ozc2g6OYa4uyhm1qQH59aXJCYnJqXWhLv7GdoaGhhZGpmbuZoTIwaAOJgLhU</recordid><startdate>20201027</startdate><enddate>20201027</enddate><creator>LI JING</creator><creator>YAN GUANGHUA</creator><creator>WANG MENG</creator><creator>LAI QINGYING</creator><creator>WANG HENG</creator><creator>CHEN YUNFU</creator><creator>LIU XINCHANG</creator><creator>REN QINGYUN</creator><creator>GUO LIANGHONG</creator><creator>LEI DOUXING</creator><creator>WANG XING'AN</creator><creator>ZHANG YINGJUN</creator><creator>YIN LIHUA</creator><scope>EVB</scope></search><sort><creationdate>20201027</creationdate><title>Dihydropyrimidine compound and application in medicine</title><author>LI JING ; YAN GUANGHUA ; WANG MENG ; LAI QINGYING ; WANG HENG ; CHEN YUNFU ; LIU XINCHANG ; REN QINGYUN ; GUO LIANGHONG ; LEI DOUXING ; WANG XING'AN ; ZHANG YINGJUN ; YIN LIHUA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN111825676A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2020</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>LI JING</creatorcontrib><creatorcontrib>YAN GUANGHUA</creatorcontrib><creatorcontrib>WANG MENG</creatorcontrib><creatorcontrib>LAI QINGYING</creatorcontrib><creatorcontrib>WANG HENG</creatorcontrib><creatorcontrib>CHEN YUNFU</creatorcontrib><creatorcontrib>LIU XINCHANG</creatorcontrib><creatorcontrib>REN QINGYUN</creatorcontrib><creatorcontrib>GUO LIANGHONG</creatorcontrib><creatorcontrib>LEI DOUXING</creatorcontrib><creatorcontrib>WANG XING'AN</creatorcontrib><creatorcontrib>ZHANG YINGJUN</creatorcontrib><creatorcontrib>YIN LIHUA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LI JING</au><au>YAN GUANGHUA</au><au>WANG MENG</au><au>LAI QINGYING</au><au>WANG HENG</au><au>CHEN YUNFU</au><au>LIU XINCHANG</au><au>REN QINGYUN</au><au>GUO LIANGHONG</au><au>LEI DOUXING</au><au>WANG XING'AN</au><au>ZHANG YINGJUN</au><au>YIN LIHUA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Dihydropyrimidine compound and application in medicine</title><date>2020-10-27</date><risdate>2020</risdate><abstract>The invention relates to a dihydropyrimidine compound and an application of the dihydropyrimidine compound as a medicine, particularly to an application of the dihydropyrimidine compound as a medicinefor treating and preventing hepatitis B, specifically to a compound represented by a general formula (I) or (Ia) or a stereoisomer, a tautomer, a nitrogen oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein each variable is defined in the specification. The invention also relates to application of the compound represented by the general formula (I) or(Ia) or the stereoisomer, tautomer, nitrogen oxide, solvate, metabolite and pharmaceutically acceptable salt thereof as a medicine, particularly to application of the compound as a medicine for treating and preventing hepatitis B.
本发明涉及一种二氢嘧啶类化合物及其作为药物的应用，尤其是作为治疗和预防乙型肝炎的药物的应用。具体地说，本发明涉及通式(I)或(Ia)所示的化合物或其立体异构体、互变异构体、氮氧化物、溶剂化物、代谢产物、药学上可接受的盐或它的前药，其中各变量如说明书所定义。本发明还涉及通式(I)或(Ia)所示的化合物或其立体异构体、互变异构体、氮氧化物、溶剂化物、代谢产物、药学上可接受的盐作为药物的用途，</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Dihydropyrimidine compound and application in medicine |
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