Application of gallic acid in preparation of medicine for treating alcoholic liver diseases
The invention discloses application of gallic acid in preparation of a medicine for treating alcoholic liver diseases, and belongs to the technical field of medicines. An animal model and a cell modelof alcoholic liver diseases are established through alcohol stimulation, the intervention effect of...
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| creator | BAO XIAOFENG REN YUANYUAN JIANG YIMING ZHOU YING WU RUOMAN PENG XIUFANG LU CHUNFENG |
| description | The invention discloses application of gallic acid in preparation of a medicine for treating alcoholic liver diseases, and belongs to the technical field of medicines. An animal model and a cell modelof alcoholic liver diseases are established through alcohol stimulation, the intervention effect of gallic acid on alcohol-induced hepatocyte damage and programmed necrosis is observed, and researches find that gallic acid can remarkably relieve alcohol-induced hepatocyte damage and inhibit programmed necrosis of hepatocytes in in-vivo and in-vitro experiments, and a new idea is provided for preventing and treating alcoholic liver diseases.
本发明公开了没食子酸在制备治疗酒精性肝病的药物中的应用，属于医药技术领域。本发明通过酒精刺激建立了酒精性肝病的动物模型和细胞模型，观察没食子酸对酒精诱导的肝细胞损伤与程序性坏死的干预作用，研究发现没食子酸在体内和体外实验中均能显著减轻酒精诱导的肝细胞损伤，抑制肝细胞程序性坏死，为预防和治疗酒精性肝病提供了新思路。 |
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本发明公开了没食子酸在制备治疗酒精性肝病的药物中的应用，属于医药技术领域。本发明通过酒精刺激建立了酒精性肝病的动物模型和细胞模型，观察没食子酸对酒精诱导的肝细胞损伤与程序性坏死的干预作用，研究发现没食子酸在体内和体外实验中均能显著减轻酒精诱导的肝细胞损伤，抑制肝细胞程序性坏死，为预防和治疗酒精性肝病提供了新思路。</description><language>chi ; eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20201013&DB=EPODOC&CC=CN&NR=111759833A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25544,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20201013&DB=EPODOC&CC=CN&NR=111759833A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BAO XIAOFENG</creatorcontrib><creatorcontrib>REN YUANYUAN</creatorcontrib><creatorcontrib>JIANG YIMING</creatorcontrib><creatorcontrib>ZHOU YING</creatorcontrib><creatorcontrib>WU RUOMAN</creatorcontrib><creatorcontrib>PENG XIUFANG</creatorcontrib><creatorcontrib>LU CHUNFENG</creatorcontrib><title>Application of gallic acid in preparation of medicine for treating alcoholic liver diseases</title><description>The invention discloses application of gallic acid in preparation of a medicine for treating alcoholic liver diseases, and belongs to the technical field of medicines. An animal model and a cell modelof alcoholic liver diseases are established through alcohol stimulation, the intervention effect of gallic acid on alcohol-induced hepatocyte damage and programmed necrosis is observed, and researches find that gallic acid can remarkably relieve alcohol-induced hepatocyte damage and inhibit programmed necrosis of hepatocytes in in-vivo and in-vitro experiments, and a new idea is provided for preventing and treating alcoholic liver diseases.
本发明公开了没食子酸在制备治疗酒精性肝病的药物中的应用，属于医药技术领域。本发明通过酒精刺激建立了酒精性肝病的动物模型和细胞模型，观察没食子酸对酒精诱导的肝细胞损伤与程序性坏死的干预作用，研究发现没食子酸在体内和体外实验中均能显著减轻酒精诱导的肝细胞损伤，抑制肝细胞程序性坏死，为预防和治疗酒精性肝病提供了新思路。</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNizEKAjEQRdNYiHqH8QAWIYhaLotiZWVnsQzJZB3IZoYkeH5XEGurx-f9tzSPTjWxx8aSQSKMmOYJ6DkAZ9BCiuVnJwrsORNEKdAKzSKPgMnLUz5Z4hcVCFwJK9W1WURMlTZfrsz2cr731x2pDFQVPWVqQ3-z1h72p6Nznfvn8wZXIDtp</recordid><startdate>20201013</startdate><enddate>20201013</enddate><creator>BAO XIAOFENG</creator><creator>REN YUANYUAN</creator><creator>JIANG YIMING</creator><creator>ZHOU YING</creator><creator>WU RUOMAN</creator><creator>PENG XIUFANG</creator><creator>LU CHUNFENG</creator><scope>EVB</scope></search><sort><creationdate>20201013</creationdate><title>Application of gallic acid in preparation of medicine for treating alcoholic liver diseases</title><author>BAO XIAOFENG ; REN YUANYUAN ; JIANG YIMING ; ZHOU YING ; WU RUOMAN ; PENG XIUFANG ; LU CHUNFENG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN111759833A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2020</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>BAO XIAOFENG</creatorcontrib><creatorcontrib>REN YUANYUAN</creatorcontrib><creatorcontrib>JIANG YIMING</creatorcontrib><creatorcontrib>ZHOU YING</creatorcontrib><creatorcontrib>WU RUOMAN</creatorcontrib><creatorcontrib>PENG XIUFANG</creatorcontrib><creatorcontrib>LU CHUNFENG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BAO XIAOFENG</au><au>REN YUANYUAN</au><au>JIANG YIMING</au><au>ZHOU YING</au><au>WU RUOMAN</au><au>PENG XIUFANG</au><au>LU CHUNFENG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Application of gallic acid in preparation of medicine for treating alcoholic liver diseases</title><date>2020-10-13</date><risdate>2020</risdate><abstract>The invention discloses application of gallic acid in preparation of a medicine for treating alcoholic liver diseases, and belongs to the technical field of medicines. An animal model and a cell modelof alcoholic liver diseases are established through alcohol stimulation, the intervention effect of gallic acid on alcohol-induced hepatocyte damage and programmed necrosis is observed, and researches find that gallic acid can remarkably relieve alcohol-induced hepatocyte damage and inhibit programmed necrosis of hepatocytes in in-vivo and in-vitro experiments, and a new idea is provided for preventing and treating alcoholic liver diseases.
本发明公开了没食子酸在制备治疗酒精性肝病的药物中的应用，属于医药技术领域。本发明通过酒精刺激建立了酒精性肝病的动物模型和细胞模型，观察没食子酸对酒精诱导的肝细胞损伤与程序性坏死的干预作用，研究发现没食子酸在体内和体外实验中均能显著减轻酒精诱导的肝细胞损伤，抑制肝细胞程序性坏死，为预防和治疗酒精性肝病提供了新思路。</abstract><oa>free_for_read</oa></addata></record> |
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| title | Application of gallic acid in preparation of medicine for treating alcoholic liver diseases |
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