Ganglioside GM3-containing nanoparticles as immunomodulators

The present invention relates to a pharmaceutical composition with an active principle that includes membrane vesicle conjugates of Neisseria meningitidis and the GM3 ganglioside in a conjugation proportion with a protein excess, with special features regarding the size, surface charge and morphology associated with nanoparticle systems that confer advantageous properties as an immunomodulator, since it induces a convenient and significant reduction of myeloid-derived suppressor cells, with an impact on lymphocyte T response and the survival of tumour patients. The invention further relates tothe use of the disclosed pharmaceutical composition for the treatment of cancer, in particular those types of cancer with an increase of myeloid-derived suppressor cells (MDSC); and to a method for treating cancer patients with this composition and to a method for selecting the patients receiving this treatment. 本发明描述了药用组合物，其活性成分包括以蛋白质过量缀合比的脑膜炎奈瑟氏球菌(Neisseria meningitidis)的膜囊泡与神经节苷脂GM3的缀合物，具有给予其作为免疫调节剂的有利特性的与纳米颗粒系统相关的尺寸、