Single crystal of 14-dehydroxyl-13-dehydroandrographolide-12-potassium sulfonate and preparation method thereof
The invention discloses a single crystal of 14-dehydroxyl-13-dehydroandrographolide-12-potassium sulfonate as well as a preparation method and application of the single crystal, and belongs to the field of drug crystal form research. According to the invention, an acid-base reaction-crystallization...
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| creator | DING YUANMIN CHANG YINGJIE ZHAO JIE LI WEN SUN KAI TANG JIANWEI LI RUIPENG LIU HONGMIN |
| description | The invention discloses a single crystal of 14-dehydroxyl-13-dehydroandrographolide-12-potassium sulfonate as well as a preparation method and application of the single crystal, and belongs to the field of drug crystal form research. According to the invention, an acid-base reaction-crystallization coupling method is adopted to obtain the 14-dehydroxyl-13-dehydroandrographolide-12-potassium sulfonate single crystal; the chemical formula is C20H29KO7S, the crystal structure belongs to a monoclinic system, and the space group is P1 21 1, a = 7.2362 angstroms, b = 7.0368 angstroms, c = 21.2746 angstroms, alpha = 90 degrees, beta = 98.485 degrees, gamma = 90 degrees, V = 1071.43 angstroms and Z = 2. Compared with an effective component 14-dehydroxy-13- dehydroandrographolide-12-sodium sulfonate of a clinical medicine Lianbizhi, on the premise of the same anti-inflammatory effect, the product has the characteristics of low impurity content and almost no hygroscopicity, and is more suitable for preparation of a hig |
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According to the invention, an acid-base reaction-crystallization coupling method is adopted to obtain the 14-dehydroxyl-13-dehydroandrographolide-12-potassium sulfonate single crystal; the chemical formula is C20H29KO7S, the crystal structure belongs to a monoclinic system, and the space group is P1 21 1, a = 7.2362 angstroms, b = 7.0368 angstroms, c = 21.2746 angstroms, alpha = 90 degrees, beta = 98.485 degrees, gamma = 90 degrees, V = 1071.43 angstroms and Z = 2. Compared with an effective component 14-dehydroxy-13- dehydroandrographolide-12-sodium sulfonate of a clinical medicine Lianbizhi, on the premise of the same anti-inflammatory effect, the product has the characteristics of low impurity content and almost no hygroscopicity, and is more suitable for preparation of a hig</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200922&DB=EPODOC&CC=CN&NR=111689934A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200922&DB=EPODOC&CC=CN&NR=111689934A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DING YUANMIN</creatorcontrib><creatorcontrib>CHANG YINGJIE</creatorcontrib><creatorcontrib>ZHAO JIE</creatorcontrib><creatorcontrib>LI WEN</creatorcontrib><creatorcontrib>SUN KAI</creatorcontrib><creatorcontrib>TANG JIANWEI</creatorcontrib><creatorcontrib>LI RUIPENG</creatorcontrib><creatorcontrib>LIU HONGMIN</creatorcontrib><title>Single crystal of 14-dehydroxyl-13-dehydroandrographolide-12-potassium sulfonate and preparation method thereof</title><description>The invention discloses a single crystal of 14-dehydroxyl-13-dehydroandrographolide-12-potassium sulfonate as well as a preparation method and application of the single crystal, and belongs to the field of drug crystal form research. 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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Single crystal of 14-dehydroxyl-13-dehydroandrographolide-12-potassium sulfonate and preparation method thereof |
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