Preparation method of 5-tert-butyl-4-ethyl-3-methyl-dihydro-3H-imidazopyridine-(4H)-dicarboxylate

The invention relates to a preparation method of 5-tert-butyl-4-ethyl-3-methyl-dihydro-3H-imidazopyridine-(4H)-dicarboxylate, and mainly solves the technical problem that a suitable industrial synthesis method does not exist at present. The method comprises the following three steps: 1, reacting a c...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	YU LINGBO, TAN RUPENG, GAO MINGFEI, WEI XINRUI, MA RUJIAN, FU XINYU, JIA TAO, BAI YOUYIN, ZHAO TING, ZHOU QIANG, SUN CHUN, ZHANG DAWEI, LAN QIANQIAN, YAO BAOYUAN, WANG XI, WEI WEI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page
container_issue
container_start_page
container_title
container_volume
creator	YU LINGBO TAN RUPENG GAO MINGFEI WEI XINRUI MA RUJIAN FU XINYU JIA TAO BAI YOUYIN ZHAO TING ZHOU QIANG SUN CHUN ZHANG DAWEI LAN QIANQIAN YAO BAOYUAN WANG XI WEI WEI
description	The invention relates to a preparation method of 5-tert-butyl-4-ethyl-3-methyl-dihydro-3H-imidazopyridine-(4H)-dicarboxylate, and mainly solves the technical problem that a suitable industrial synthesis method does not exist at present. The method comprises the following three steps: 1, reacting a compound 1 in hydrochloric acid to obtain a compound 2; 2, reacting the compound 2 with an ethyl glyoxylate toluene solution in acetonitrile to obtain a compound 3; and 3, reacting the compound 3 with Boc anhydride and triethylamine in dichloromethane to obtain a final compound 4. The reaction formula is shown in the specification. 本发明涉及一种5-叔丁基-4-乙基-3-甲基-二氢-3H-咪唑并吡啶-(4H)-二甲酸基酯制法，主要解决目前没有适合工业化合成方法的技术问题。本发明分三步，第一步，首先由化合物1在盐酸中反应得到化合物2，第二步，化合物2与乙醛酸乙酯甲苯溶液在乙腈中反应得到化合物3，第三步，化合物3与Boc酸酐和三乙胺在二氯甲烷中反应得到最终化合物4，反应式如下：。
format	Patent
fullrecord	<record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN111662287A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN111662287A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN111662287A3</originalsourceid><addsrcrecordid>eNqNirsKwkAQRdNYiPoPsdNiijyMthKUVGJhHybZCVnI7iybEVy_3gX9AKtzOfcsE7x7cuhRNNvUkIysUh7SAwh5ge4pYYISoo8swHyH0mNQnqFoQBut8M0ueK20JdiVzT7-PfqOX2FCoXWyGHCaafPjKtleL4-6AXLc0uywJ0vS1rcsy6oqz0_Hc_FP8wGALjyx</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Preparation method of 5-tert-butyl-4-ethyl-3-methyl-dihydro-3H-imidazopyridine-(4H)-dicarboxylate</title><source>esp@cenet</source><creator>YU LINGBO ; TAN RUPENG ; GAO MINGFEI ; WEI XINRUI ; MA RUJIAN ; FU XINYU ; JIA TAO ; BAI YOUYIN ; ZHAO TING ; ZHOU QIANG ; SUN CHUN ; ZHANG DAWEI ; LAN QIANQIAN ; YAO BAOYUAN ; WANG XI ; WEI WEI</creator><creatorcontrib>YU LINGBO ; TAN RUPENG ; GAO MINGFEI ; WEI XINRUI ; MA RUJIAN ; FU XINYU ; JIA TAO ; BAI YOUYIN ; ZHAO TING ; ZHOU QIANG ; SUN CHUN ; ZHANG DAWEI ; LAN QIANQIAN ; YAO BAOYUAN ; WANG XI ; WEI WEI</creatorcontrib><description>The invention relates to a preparation method of 5-tert-butyl-4-ethyl-3-methyl-dihydro-3H-imidazopyridine-(4H)-dicarboxylate, and mainly solves the technical problem that a suitable industrial synthesis method does not exist at present. The method comprises the following three steps: 1, reacting a compound 1 in hydrochloric acid to obtain a compound 2; 2, reacting the compound 2 with an ethyl glyoxylate toluene solution in acetonitrile to obtain a compound 3; and 3, reacting the compound 3 with Boc anhydride and triethylamine in dichloromethane to obtain a final compound 4. The reaction formula is shown in the specification. 本发明涉及一种5-叔丁基-4-乙基-3-甲基-二氢-3H-咪唑并吡啶-(4H)-二甲酸基酯制法，主要解决目前没有适合工业化合成方法的技术问题。本发明分三步，第一步，首先由化合物1在盐酸中反应得到化合物2，第二步，化合物2与乙醛酸乙酯甲苯溶液在乙腈中反应得到化合物3，第三步，化合物3与Boc酸酐和三乙胺在二氯甲烷中反应得到最终化合物4，反应式如下：。</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200915&DB=EPODOC&CC=CN&NR=111662287A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200915&DB=EPODOC&CC=CN&NR=111662287A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>YU LINGBO</creatorcontrib><creatorcontrib>TAN RUPENG</creatorcontrib><creatorcontrib>GAO MINGFEI</creatorcontrib><creatorcontrib>WEI XINRUI</creatorcontrib><creatorcontrib>MA RUJIAN</creatorcontrib><creatorcontrib>FU XINYU</creatorcontrib><creatorcontrib>JIA TAO</creatorcontrib><creatorcontrib>BAI YOUYIN</creatorcontrib><creatorcontrib>ZHAO TING</creatorcontrib><creatorcontrib>ZHOU QIANG</creatorcontrib><creatorcontrib>SUN CHUN</creatorcontrib><creatorcontrib>ZHANG DAWEI</creatorcontrib><creatorcontrib>LAN QIANQIAN</creatorcontrib><creatorcontrib>YAO BAOYUAN</creatorcontrib><creatorcontrib>WANG XI</creatorcontrib><creatorcontrib>WEI WEI</creatorcontrib><title>Preparation method of 5-tert-butyl-4-ethyl-3-methyl-dihydro-3H-imidazopyridine-(4H)-dicarboxylate</title><description>The invention relates to a preparation method of 5-tert-butyl-4-ethyl-3-methyl-dihydro-3H-imidazopyridine-(4H)-dicarboxylate, and mainly solves the technical problem that a suitable industrial synthesis method does not exist at present. The method comprises the following three steps: 1, reacting a compound 1 in hydrochloric acid to obtain a compound 2; 2, reacting the compound 2 with an ethyl glyoxylate toluene solution in acetonitrile to obtain a compound 3; and 3, reacting the compound 3 with Boc anhydride and triethylamine in dichloromethane to obtain a final compound 4. The reaction formula is shown in the specification. 本发明涉及一种5-叔丁基-4-乙基-3-甲基-二氢-3H-咪唑并吡啶-(4H)-二甲酸基酯制法，主要解决目前没有适合工业化合成方法的技术问题。本发明分三步，第一步，首先由化合物1在盐酸中反应得到化合物2，第二步，化合物2与乙醛酸乙酯甲苯溶液在乙腈中反应得到化合物3，第三步，化合物3与Boc酸酐和三乙胺在二氯甲烷中反应得到最终化合物4，反应式如下：。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNirsKwkAQRdNYiPoPsdNiijyMthKUVGJhHybZCVnI7iybEVy_3gX9AKtzOfcsE7x7cuhRNNvUkIysUh7SAwh5ge4pYYISoo8swHyH0mNQnqFoQBut8M0ueK20JdiVzT7-PfqOX2FCoXWyGHCaafPjKtleL4-6AXLc0uywJ0vS1rcsy6oqz0_Hc_FP8wGALjyx</recordid><startdate>20200915</startdate><enddate>20200915</enddate><creator>YU LINGBO</creator><creator>TAN RUPENG</creator><creator>GAO MINGFEI</creator><creator>WEI XINRUI</creator><creator>MA RUJIAN</creator><creator>FU XINYU</creator><creator>JIA TAO</creator><creator>BAI YOUYIN</creator><creator>ZHAO TING</creator><creator>ZHOU QIANG</creator><creator>SUN CHUN</creator><creator>ZHANG DAWEI</creator><creator>LAN QIANQIAN</creator><creator>YAO BAOYUAN</creator><creator>WANG XI</creator><creator>WEI WEI</creator><scope>EVB</scope></search><sort><creationdate>20200915</creationdate><title>Preparation method of 5-tert-butyl-4-ethyl-3-methyl-dihydro-3H-imidazopyridine-(4H)-dicarboxylate</title><author>YU LINGBO ; TAN RUPENG ; GAO MINGFEI ; WEI XINRUI ; MA RUJIAN ; FU XINYU ; JIA TAO ; BAI YOUYIN ; ZHAO TING ; ZHOU QIANG ; SUN CHUN ; ZHANG DAWEI ; LAN QIANQIAN ; YAO BAOYUAN ; WANG XI ; WEI WEI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN111662287A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2020</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>YU LINGBO</creatorcontrib><creatorcontrib>TAN RUPENG</creatorcontrib><creatorcontrib>GAO MINGFEI</creatorcontrib><creatorcontrib>WEI XINRUI</creatorcontrib><creatorcontrib>MA RUJIAN</creatorcontrib><creatorcontrib>FU XINYU</creatorcontrib><creatorcontrib>JIA TAO</creatorcontrib><creatorcontrib>BAI YOUYIN</creatorcontrib><creatorcontrib>ZHAO TING</creatorcontrib><creatorcontrib>ZHOU QIANG</creatorcontrib><creatorcontrib>SUN CHUN</creatorcontrib><creatorcontrib>ZHANG DAWEI</creatorcontrib><creatorcontrib>LAN QIANQIAN</creatorcontrib><creatorcontrib>YAO BAOYUAN</creatorcontrib><creatorcontrib>WANG XI</creatorcontrib><creatorcontrib>WEI WEI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>YU LINGBO</au><au>TAN RUPENG</au><au>GAO MINGFEI</au><au>WEI XINRUI</au><au>MA RUJIAN</au><au>FU XINYU</au><au>JIA TAO</au><au>BAI YOUYIN</au><au>ZHAO TING</au><au>ZHOU QIANG</au><au>SUN CHUN</au><au>ZHANG DAWEI</au><au>LAN QIANQIAN</au><au>YAO BAOYUAN</au><au>WANG XI</au><au>WEI WEI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Preparation method of 5-tert-butyl-4-ethyl-3-methyl-dihydro-3H-imidazopyridine-(4H)-dicarboxylate</title><date>2020-09-15</date><risdate>2020</risdate><abstract>The invention relates to a preparation method of 5-tert-butyl-4-ethyl-3-methyl-dihydro-3H-imidazopyridine-(4H)-dicarboxylate, and mainly solves the technical problem that a suitable industrial synthesis method does not exist at present. The method comprises the following three steps: 1, reacting a compound 1 in hydrochloric acid to obtain a compound 2; 2, reacting the compound 2 with an ethyl glyoxylate toluene solution in acetonitrile to obtain a compound 3; and 3, reacting the compound 3 with Boc anhydride and triethylamine in dichloromethane to obtain a final compound 4. The reaction formula is shown in the specification. 本发明涉及一种5-叔丁基-4-乙基-3-甲基-二氢-3H-咪唑并吡啶-(4H)-二甲酸基酯制法，主要解决目前没有适合工业化合成方法的技术问题。本发明分三步，第一步，首先由化合物1在盐酸中反应得到化合物2，第二步，化合物2与乙醛酸乙酯甲苯溶液在乙腈中反应得到化合物3，第三步，化合物3与Boc酸酐和三乙胺在二氯甲烷中反应得到最终化合物4，反应式如下：。</abstract><oa>free_for_read</oa></addata></record>
fulltext	fulltext_linktorsrc
identifier
ispartof
issn
language	chi ; eng
recordid	cdi_epo_espacenet_CN111662287A
source	esp@cenet
subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
title	Preparation method of 5-tert-butyl-4-ethyl-3-methyl-dihydro-3H-imidazopyridine-(4H)-dicarboxylate
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T23%3A09%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=YU%20LINGBO&rft.date=2020-09-15&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN111662287A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true