Preparation method of 5-tert-butyl-4-ethyl-3-methyl-dihydro-3H-imidazopyridine-(4H)-dicarboxylate

The invention relates to a preparation method of 5-tert-butyl-4-ethyl-3-methyl-dihydro-3H-imidazopyridine-(4H)-dicarboxylate, and mainly solves the technical problem that a suitable industrial synthesis method does not exist at present. The method comprises the following three steps: 1, reacting a compound 1 in hydrochloric acid to obtain a compound 2; 2, reacting the compound 2 with an ethyl glyoxylate toluene solution in acetonitrile to obtain a compound 3; and 3, reacting the compound 3 with Boc anhydride and triethylamine in dichloromethane to obtain a final compound 4. The reaction formula is shown in the specification. 本发明涉及一种5-叔丁基-4-乙基-3-甲基-二氢-3H-咪唑并吡啶-(4H)-二甲酸基酯制法，主要解决目前没有适合工业化合成方法的技术问题。本发明分三步，第一步，首先由化合物1在盐酸中反应得到化合物2，第二步，化合物2与乙醛酸乙酯甲苯溶液在乙腈中反应得到化合物3，第三步，化合物3与Boc酸酐和三乙胺在二氯甲烷中反应得到最终化合物4，反应式如下：。