Preparation method of 2-(tert-butoxycarbonyl)-7-oxyalkylene-2, 6-diazaspiro [3.4] octane-5-carboxylic acid
The invention relates to a preparation method of 2-(tert-butoxycarbonyl)-7-oxyalkylene-2, 6-diazaspiro [3.4] octane-5-carboxylic acid, and mainly solves the technical problem that no suitable industrial synthesis method exists at present. The method comprises the following four steps: step 1, adding...
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| creator | YU LINGBO TAN RUPENG GAO MINGFEI WEI XINRUI MA RUJIAN FU XINYU JIA TAO BAI YOUYIN ZHAO TING ZHOU QIANG SUN CHUN ZHANG DAWEI LAN QIANQIAN YAO BAOYUAN WANG XI WEI WEI |
| description | The invention relates to a preparation method of 2-(tert-butoxycarbonyl)-7-oxyalkylene-2, 6-diazaspiro [3.4] octane-5-carboxylic acid, and mainly solves the technical problem that no suitable industrial synthesis method exists at present. The method comprises the following four steps: step 1, adding ethyl nitroacetate and 1.8-diazabicyclo [5.4. 0] undecyl-7-ene into a solvent acetonitrile to reactwith a compound 1 so as to obtain a compound 2; 2, reacting the compound 2 with raney nickel and introducing hydrogen in methanol to obtain a compound 3 and a compound 4; 3, adding sodium ethoxide into a solvent ethanol to react with the compound 3 and the compound 4 to obtain a compound 5; and 4, reacting the compound 5 with sodium hydroxide in ethanol and water to obtain a final compound 6. Thereaction formula is in the step 4 is described in the descriptions of the invention.
本发明涉及一种2-(叔丁氧基羰基)-7-氧亚基-2,6-二氮杂螺[3.4]辛烷-5-羧酸制法，主要解决目前没有适合工业化合成方法的技术问题。本发明分四步，第一步，首先由化合物1在溶剂乙腈中加入硝基乙酸乙基酯和1.8-二氮杂二环[5.4.0]十一烷-7-烯反应得到化合物2，第二步， |
| format | Patent |
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本发明涉及一种2-(叔丁氧基羰基)-7-氧亚基-2,6-二氮杂螺[3.4]辛烷-5-羧酸制法，主要解决目前没有适合工业化合成方法的技术问题。本发明分四步，第一步，首先由化合物1在溶剂乙腈中加入硝基乙酸乙基酯和1.8-二氮杂二环[5.4.0]十一烷-7-烯反应得到化合物2，第二步，</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200825&DB=EPODOC&CC=CN&NR=111574524A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200825&DB=EPODOC&CC=CN&NR=111574524A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>YU LINGBO</creatorcontrib><creatorcontrib>TAN RUPENG</creatorcontrib><creatorcontrib>GAO MINGFEI</creatorcontrib><creatorcontrib>WEI XINRUI</creatorcontrib><creatorcontrib>MA RUJIAN</creatorcontrib><creatorcontrib>FU XINYU</creatorcontrib><creatorcontrib>JIA TAO</creatorcontrib><creatorcontrib>BAI YOUYIN</creatorcontrib><creatorcontrib>ZHAO TING</creatorcontrib><creatorcontrib>ZHOU QIANG</creatorcontrib><creatorcontrib>SUN CHUN</creatorcontrib><creatorcontrib>ZHANG DAWEI</creatorcontrib><creatorcontrib>LAN QIANQIAN</creatorcontrib><creatorcontrib>YAO BAOYUAN</creatorcontrib><creatorcontrib>WANG XI</creatorcontrib><creatorcontrib>WEI WEI</creatorcontrib><title>Preparation method of 2-(tert-butoxycarbonyl)-7-oxyalkylene-2, 6-diazaspiro [3.4] octane-5-carboxylic acid</title><description>The invention relates to a preparation method of 2-(tert-butoxycarbonyl)-7-oxyalkylene-2, 6-diazaspiro [3.4] octane-5-carboxylic acid, and mainly solves the technical problem that no suitable industrial synthesis method exists at present. The method comprises the following four steps: step 1, adding ethyl nitroacetate and 1.8-diazabicyclo [5.4. 0] undecyl-7-ene into a solvent acetonitrile to reactwith a compound 1 so as to obtain a compound 2; 2, reacting the compound 2 with raney nickel and introducing hydrogen in methanol to obtain a compound 3 and a compound 4; 3, adding sodium ethoxide into a solvent ethanol to react with the compound 3 and the compound 4 to obtain a compound 5; and 4, reacting the compound 5 with sodium hydroxide in ethanol and water to obtain a final compound 6. Thereaction formula is in the step 4 is described in the descriptions of the invention.
本发明涉及一种2-(叔丁氧基羰基)-7-氧亚基-2,6-二氮杂螺[3.4]辛烷-5-羧酸制法，主要解决目前没有适合工业化合成方法的技术问题。本发明分四步，第一步，首先由化合物1在溶剂乙腈中加入硝基乙酸乙基酯和1.8-二氮杂二环[5.4.0]十一烷-7-烯反应得到化合物2，第二步，</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjM0KwjAQhHvxIOo7xJuCK_TPnqUonsSDN5GyTbYYjd2QRmh8eov4AJ6G4ZtvxtH95MiiQ6-5FU_yN1aCG5HAwpPzUL8890Giq7kNZgkFDBXNIxhqCZKV2IDS-MbOasfikq6zq2DpcYA5fLU-GC0FSq2m0ahB09Hsl5Novt-dywOQ5Yo6i3L49FV5jOM4L7I8ybbpP5sPpeE_Kg</recordid><startdate>20200825</startdate><enddate>20200825</enddate><creator>YU LINGBO</creator><creator>TAN RUPENG</creator><creator>GAO MINGFEI</creator><creator>WEI XINRUI</creator><creator>MA RUJIAN</creator><creator>FU XINYU</creator><creator>JIA TAO</creator><creator>BAI YOUYIN</creator><creator>ZHAO TING</creator><creator>ZHOU QIANG</creator><creator>SUN CHUN</creator><creator>ZHANG DAWEI</creator><creator>LAN QIANQIAN</creator><creator>YAO BAOYUAN</creator><creator>WANG XI</creator><creator>WEI WEI</creator><scope>EVB</scope></search><sort><creationdate>20200825</creationdate><title>Preparation method of 2-(tert-butoxycarbonyl)-7-oxyalkylene-2, 6-diazaspiro [3.4] octane-5-carboxylic acid</title><author>YU LINGBO ; TAN RUPENG ; GAO MINGFEI ; WEI XINRUI ; MA RUJIAN ; FU XINYU ; JIA TAO ; BAI YOUYIN ; ZHAO TING ; ZHOU QIANG ; SUN CHUN ; ZHANG DAWEI ; LAN QIANQIAN ; YAO BAOYUAN ; WANG XI ; WEI WEI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN111574524A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2020</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>YU LINGBO</creatorcontrib><creatorcontrib>TAN RUPENG</creatorcontrib><creatorcontrib>GAO MINGFEI</creatorcontrib><creatorcontrib>WEI XINRUI</creatorcontrib><creatorcontrib>MA RUJIAN</creatorcontrib><creatorcontrib>FU XINYU</creatorcontrib><creatorcontrib>JIA TAO</creatorcontrib><creatorcontrib>BAI YOUYIN</creatorcontrib><creatorcontrib>ZHAO TING</creatorcontrib><creatorcontrib>ZHOU QIANG</creatorcontrib><creatorcontrib>SUN CHUN</creatorcontrib><creatorcontrib>ZHANG DAWEI</creatorcontrib><creatorcontrib>LAN QIANQIAN</creatorcontrib><creatorcontrib>YAO BAOYUAN</creatorcontrib><creatorcontrib>WANG XI</creatorcontrib><creatorcontrib>WEI WEI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>YU LINGBO</au><au>TAN RUPENG</au><au>GAO MINGFEI</au><au>WEI XINRUI</au><au>MA RUJIAN</au><au>FU XINYU</au><au>JIA TAO</au><au>BAI YOUYIN</au><au>ZHAO TING</au><au>ZHOU QIANG</au><au>SUN CHUN</au><au>ZHANG DAWEI</au><au>LAN QIANQIAN</au><au>YAO BAOYUAN</au><au>WANG XI</au><au>WEI WEI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Preparation method of 2-(tert-butoxycarbonyl)-7-oxyalkylene-2, 6-diazaspiro [3.4] octane-5-carboxylic acid</title><date>2020-08-25</date><risdate>2020</risdate><abstract>The invention relates to a preparation method of 2-(tert-butoxycarbonyl)-7-oxyalkylene-2, 6-diazaspiro [3.4] octane-5-carboxylic acid, and mainly solves the technical problem that no suitable industrial synthesis method exists at present. The method comprises the following four steps: step 1, adding ethyl nitroacetate and 1.8-diazabicyclo [5.4. 0] undecyl-7-ene into a solvent acetonitrile to reactwith a compound 1 so as to obtain a compound 2; 2, reacting the compound 2 with raney nickel and introducing hydrogen in methanol to obtain a compound 3 and a compound 4; 3, adding sodium ethoxide into a solvent ethanol to react with the compound 3 and the compound 4 to obtain a compound 5; and 4, reacting the compound 5 with sodium hydroxide in ethanol and water to obtain a final compound 6. Thereaction formula is in the step 4 is described in the descriptions of the invention.
本发明涉及一种2-(叔丁氧基羰基)-7-氧亚基-2,6-二氮杂螺[3.4]辛烷-5-羧酸制法，主要解决目前没有适合工业化合成方法的技术问题。本发明分四步，第一步，首先由化合物1在溶剂乙腈中加入硝基乙酸乙基酯和1.8-二氮杂二环[5.4.0]十一烷-7-烯反应得到化合物2，第二步，</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | Preparation method of 2-(tert-butoxycarbonyl)-7-oxyalkylene-2, 6-diazaspiro [3.4] octane-5-carboxylic acid |
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