Synthesis method of 5-tert-butyl-2-methyl hydroxybenzoate
The invention discloses a synthesis method of methyl 5-tert-butyl-2-hydroxybenzoate, and belongs to the technical field of organic synthesis. The synthesis method comprises the following steps of: S1,taking methyl salicylate and tert-butyl alcohol as raw materials, and preparing a mixture of a compo...
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| creator | WANG LEI WANG XIAOWEI CAO HENGMING WU FENG HE HANJIANG |
| description | The invention discloses a synthesis method of methyl 5-tert-butyl-2-hydroxybenzoate, and belongs to the technical field of organic synthesis. The synthesis method comprises the following steps of: S1,taking methyl salicylate and tert-butyl alcohol as raw materials, and preparing a mixture of a compound shown as a formula (I), a compound shown as a formula (II) and a compound shown as a formula (III) under the catalytic action of concentrated sulfuric acid; and S2, carrying out a rearrangement reaction on the mixture prepared in the step S1 under the catalysis of Lewis acid, and carrying out post-treatment to prepare a pure compound shown in the formula (I), namely the 5-tert-butyl-2-methyl hydroxybenzoate. The synthesis method of the 5-tert-butyl-2-methyl hydroxybenzoate is low in production cost, novel in preparation route, simple in equipment and easy for industrial production, and can be widely applied to the field of production of fine chemicals.
本发明公开了一种5-叔丁基-2-羟基苯甲酸甲酯的合成方法，属于有机合成技术领域，包括以下步骤：S1、以水杨酸甲酯和叔丁 |
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本发明公开了一种5-叔丁基-2-羟基苯甲酸甲酯的合成方法，属于有机合成技术领域，包括以下步骤：S1、以水杨酸甲酯和叔丁</description><language>chi ; eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200825&DB=EPODOC&CC=CN&NR=111574368A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200825&DB=EPODOC&CC=CN&NR=111574368A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WANG LEI</creatorcontrib><creatorcontrib>WANG XIAOWEI</creatorcontrib><creatorcontrib>CAO HENGMING</creatorcontrib><creatorcontrib>WU FENG</creatorcontrib><creatorcontrib>HE HANJIANG</creatorcontrib><title>Synthesis method of 5-tert-butyl-2-methyl hydroxybenzoate</title><description>The invention discloses a synthesis method of methyl 5-tert-butyl-2-hydroxybenzoate, and belongs to the technical field of organic synthesis. The synthesis method comprises the following steps of: S1,taking methyl salicylate and tert-butyl alcohol as raw materials, and preparing a mixture of a compound shown as a formula (I), a compound shown as a formula (II) and a compound shown as a formula (III) under the catalytic action of concentrated sulfuric acid; and S2, carrying out a rearrangement reaction on the mixture prepared in the step S1 under the catalysis of Lewis acid, and carrying out post-treatment to prepare a pure compound shown in the formula (I), namely the 5-tert-butyl-2-methyl hydroxybenzoate. The synthesis method of the 5-tert-butyl-2-methyl hydroxybenzoate is low in production cost, novel in preparation route, simple in equipment and easy for industrial production, and can be widely applied to the field of production of fine chemicals.
本发明公开了一种5-叔丁基-2-羟基苯甲酸甲酯的合成方法，属于有机合成技术领域，包括以下步骤：S1、以水杨酸甲酯和叔丁</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAMrswryUgtzixWyE0tychPUchPUzDVLUktKtFNKi2pzNE10gVJVOYoZFSmFOVXVCal5lXlJ5ak8jCwpiXmFKfyQmluBkU31xBnD93Ugvz41OKCxOTUvNSSeGc_Q0NDU3MTYzMLR2Ni1AAARnsu1A</recordid><startdate>20200825</startdate><enddate>20200825</enddate><creator>WANG LEI</creator><creator>WANG XIAOWEI</creator><creator>CAO HENGMING</creator><creator>WU FENG</creator><creator>HE HANJIANG</creator><scope>EVB</scope></search><sort><creationdate>20200825</creationdate><title>Synthesis method of 5-tert-butyl-2-methyl hydroxybenzoate</title><author>WANG LEI ; WANG XIAOWEI ; CAO HENGMING ; WU FENG ; HE HANJIANG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN111574368A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2020</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>WANG LEI</creatorcontrib><creatorcontrib>WANG XIAOWEI</creatorcontrib><creatorcontrib>CAO HENGMING</creatorcontrib><creatorcontrib>WU FENG</creatorcontrib><creatorcontrib>HE HANJIANG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WANG LEI</au><au>WANG XIAOWEI</au><au>CAO HENGMING</au><au>WU FENG</au><au>HE HANJIANG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Synthesis method of 5-tert-butyl-2-methyl hydroxybenzoate</title><date>2020-08-25</date><risdate>2020</risdate><abstract>The invention discloses a synthesis method of methyl 5-tert-butyl-2-hydroxybenzoate, and belongs to the technical field of organic synthesis. The synthesis method comprises the following steps of: S1,taking methyl salicylate and tert-butyl alcohol as raw materials, and preparing a mixture of a compound shown as a formula (I), a compound shown as a formula (II) and a compound shown as a formula (III) under the catalytic action of concentrated sulfuric acid; and S2, carrying out a rearrangement reaction on the mixture prepared in the step S1 under the catalysis of Lewis acid, and carrying out post-treatment to prepare a pure compound shown in the formula (I), namely the 5-tert-butyl-2-methyl hydroxybenzoate. The synthesis method of the 5-tert-butyl-2-methyl hydroxybenzoate is low in production cost, novel in preparation route, simple in equipment and easy for industrial production, and can be widely applied to the field of production of fine chemicals.
本发明公开了一种5-叔丁基-2-羟基苯甲酸甲酯的合成方法，属于有机合成技术领域，包括以下步骤：S1、以水杨酸甲酯和叔丁</abstract><oa>free_for_read</oa></addata></record> |
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| title | Synthesis method of 5-tert-butyl-2-methyl hydroxybenzoate |
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