Bone fusion hydrogel scaffold and preparation method thereof
The invention discloses a bone fusion hydrogel scaffold and a preparation method thereof. The bone fusion hydrogel scaffold is subjected to 3D printing under ultraviolet excitation to form a cell scaffold with a three-dimensional structure; the bone fusion hydrogel scaffold comprises a drug loading...
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| creator | QIN XIAODONG YANG JUNCHI HE ZHONG ZHU ZEZHANG GE HAIXIONG |
| description | The invention discloses a bone fusion hydrogel scaffold and a preparation method thereof. The bone fusion hydrogel scaffold is subjected to 3D printing under ultraviolet excitation to form a cell scaffold with a three-dimensional structure; the bone fusion hydrogel scaffold comprises a drug loading layer, a first osteogenesis mediation layer and a second osteogenesis mediation layer which are subjected to 3D printing to form a reticular disc structure; the drug loading layer, the first osteogenesis mediation layer and the second osteogenesis mediation layer are sequentially adhered and cured from top to bottom through polymer hydrogel to form the multilayer and porous hydrogel scaffold; the drug loading layer is prepared from the polymer hydrogel and rhBMP-2-loaded 2-N, 6-O-sulfated chitosan (rhBMP-2/NPs); and the first osteogenesis mediation layer and the second osteogenesis mediation layer are prepared from the polymer hydrogel and hydroxyapatite nanocrystals (nHA). The prepared bonefusion hydrogel scaffold |
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The bone fusion hydrogel scaffold is subjected to 3D printing under ultraviolet excitation to form a cell scaffold with a three-dimensional structure; the bone fusion hydrogel scaffold comprises a drug loading layer, a first osteogenesis mediation layer and a second osteogenesis mediation layer which are subjected to 3D printing to form a reticular disc structure; the drug loading layer, the first osteogenesis mediation layer and the second osteogenesis mediation layer are sequentially adhered and cured from top to bottom through polymer hydrogel to form the multilayer and porous hydrogel scaffold; the drug loading layer is prepared from the polymer hydrogel and rhBMP-2-loaded 2-N, 6-O-sulfated chitosan (rhBMP-2/NPs); and the first osteogenesis mediation layer and the second osteogenesis mediation layer are prepared from the polymer hydrogel and hydroxyapatite nanocrystals (nHA). 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| subjects | ADDITIVE MANUFACTURING TECHNOLOGY ADDITIVE MANUFACTURING, i.e. MANUFACTURING OFTHREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVEAGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING,STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL PERFORMING OPERATIONS TRANSPORTING |
| title | Bone fusion hydrogel scaffold and preparation method thereof |
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