Gapmer oligonucleotides comprising a phosphorodithioate internucleoside linkage
The present invention relates to a gapmer oligonucleotide comprising at phosphorodithioate internucleoside linkage of formula (I) as defined in the description and in the claims. The oligonucleotide of the invention can be used as a medicement. 本发明涉及一种缺口聚物寡核苷酸，其包含如本说明书中和权利要求书中所定义的式(I)的二硫代磷酸酯核苷间键。本发明...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | SCHAEUBLIN ADRIAN HANSEN HENRIK FRYDENLUND DUSCHMALE JOERG WU YONG DUSCHMALE MARTINA BRIGITTE KOCH TROELS SHU XI FUNDER ERIK BLEICHER KONRAD LI MEILING |
| description | The present invention relates to a gapmer oligonucleotide comprising at phosphorodithioate internucleoside linkage of formula (I) as defined in the description and in the claims. The oligonucleotide of the invention can be used as a medicement.
本发明涉及一种缺口聚物寡核苷酸，其包含如本说明书中和权利要求书中所定义的式(I)的二硫代磷酸酯核苷间键。本发明的寡核苷酸可以用作药物。 |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN111448317A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN111448317A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN111448317A3</originalsourceid><addsrcrecordid>eNqNizsOwjAMQLMwIOAO5gAMUSvBiio-EyzslZWa1CK1ozjcn0pwAIant7y3dPcL5okKaOKo8g6JtPJABkGnXNhYIiDkUW2m6MB1ZMVKwFKpfAebB0gsL4y0dosnJqPNzyu3PZ8e3XVHWXuyjIGEat_dvPdte2j8_tj803wAFEQ4aA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Gapmer oligonucleotides comprising a phosphorodithioate internucleoside linkage</title><source>esp@cenet</source><creator>SCHAEUBLIN ADRIAN ; HANSEN HENRIK FRYDENLUND ; DUSCHMALE JOERG ; WU YONG ; DUSCHMALE MARTINA BRIGITTE ; KOCH TROELS ; SHU XI ; FUNDER ERIK ; BLEICHER KONRAD ; LI MEILING</creator><creatorcontrib>SCHAEUBLIN ADRIAN ; HANSEN HENRIK FRYDENLUND ; DUSCHMALE JOERG ; WU YONG ; DUSCHMALE MARTINA BRIGITTE ; KOCH TROELS ; SHU XI ; FUNDER ERIK ; BLEICHER KONRAD ; LI MEILING</creatorcontrib><description>The present invention relates to a gapmer oligonucleotide comprising at phosphorodithioate internucleoside linkage of formula (I) as defined in the description and in the claims. The oligonucleotide of the invention can be used as a medicement.
本发明涉及一种缺口聚物寡核苷酸，其包含如本说明书中和权利要求书中所定义的式(I)的二硫代磷酸酯核苷间键。本发明的寡核苷酸可以用作药物。</description><language>chi ; eng</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; DERIVATIVES THEREOF ; ENZYMOLOGY ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; SUGARS ; VINEGAR ; WINE</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200724&DB=EPODOC&CC=CN&NR=111448317A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200724&DB=EPODOC&CC=CN&NR=111448317A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SCHAEUBLIN ADRIAN</creatorcontrib><creatorcontrib>HANSEN HENRIK FRYDENLUND</creatorcontrib><creatorcontrib>DUSCHMALE JOERG</creatorcontrib><creatorcontrib>WU YONG</creatorcontrib><creatorcontrib>DUSCHMALE MARTINA BRIGITTE</creatorcontrib><creatorcontrib>KOCH TROELS</creatorcontrib><creatorcontrib>SHU XI</creatorcontrib><creatorcontrib>FUNDER ERIK</creatorcontrib><creatorcontrib>BLEICHER KONRAD</creatorcontrib><creatorcontrib>LI MEILING</creatorcontrib><title>Gapmer oligonucleotides comprising a phosphorodithioate internucleoside linkage</title><description>The present invention relates to a gapmer oligonucleotide comprising at phosphorodithioate internucleoside linkage of formula (I) as defined in the description and in the claims. The oligonucleotide of the invention can be used as a medicement.
本发明涉及一种缺口聚物寡核苷酸，其包含如本说明书中和权利要求书中所定义的式(I)的二硫代磷酸酯核苷间键。本发明的寡核苷酸可以用作药物。</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>DERIVATIVES THEREOF</subject><subject>ENZYMOLOGY</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>SUGARS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNizsOwjAMQLMwIOAO5gAMUSvBiio-EyzslZWa1CK1ozjcn0pwAIant7y3dPcL5okKaOKo8g6JtPJABkGnXNhYIiDkUW2m6MB1ZMVKwFKpfAebB0gsL4y0dosnJqPNzyu3PZ8e3XVHWXuyjIGEat_dvPdte2j8_tj803wAFEQ4aA</recordid><startdate>20200724</startdate><enddate>20200724</enddate><creator>SCHAEUBLIN ADRIAN</creator><creator>HANSEN HENRIK FRYDENLUND</creator><creator>DUSCHMALE JOERG</creator><creator>WU YONG</creator><creator>DUSCHMALE MARTINA BRIGITTE</creator><creator>KOCH TROELS</creator><creator>SHU XI</creator><creator>FUNDER ERIK</creator><creator>BLEICHER KONRAD</creator><creator>LI MEILING</creator><scope>EVB</scope></search><sort><creationdate>20200724</creationdate><title>Gapmer oligonucleotides comprising a phosphorodithioate internucleoside linkage</title><author>SCHAEUBLIN ADRIAN ; HANSEN HENRIK FRYDENLUND ; DUSCHMALE JOERG ; WU YONG ; DUSCHMALE MARTINA BRIGITTE ; KOCH TROELS ; SHU XI ; FUNDER ERIK ; BLEICHER KONRAD ; LI MEILING</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN111448317A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2020</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>DERIVATIVES THEREOF</topic><topic>ENZYMOLOGY</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>SUGARS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>SCHAEUBLIN ADRIAN</creatorcontrib><creatorcontrib>HANSEN HENRIK FRYDENLUND</creatorcontrib><creatorcontrib>DUSCHMALE JOERG</creatorcontrib><creatorcontrib>WU YONG</creatorcontrib><creatorcontrib>DUSCHMALE MARTINA BRIGITTE</creatorcontrib><creatorcontrib>KOCH TROELS</creatorcontrib><creatorcontrib>SHU XI</creatorcontrib><creatorcontrib>FUNDER ERIK</creatorcontrib><creatorcontrib>BLEICHER KONRAD</creatorcontrib><creatorcontrib>LI MEILING</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SCHAEUBLIN ADRIAN</au><au>HANSEN HENRIK FRYDENLUND</au><au>DUSCHMALE JOERG</au><au>WU YONG</au><au>DUSCHMALE MARTINA BRIGITTE</au><au>KOCH TROELS</au><au>SHU XI</au><au>FUNDER ERIK</au><au>BLEICHER KONRAD</au><au>LI MEILING</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Gapmer oligonucleotides comprising a phosphorodithioate internucleoside linkage</title><date>2020-07-24</date><risdate>2020</risdate><abstract>The present invention relates to a gapmer oligonucleotide comprising at phosphorodithioate internucleoside linkage of formula (I) as defined in the description and in the claims. The oligonucleotide of the invention can be used as a medicement.
本发明涉及一种缺口聚物寡核苷酸，其包含如本说明书中和权利要求书中所定义的式(I)的二硫代磷酸酯核苷间键。本发明的寡核苷酸可以用作药物。</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_CN111448317A |
| source | esp@cenet |
| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS VINEGAR WINE |
| title | Gapmer oligonucleotides comprising a phosphorodithioate internucleoside linkage |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T12%3A00%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=SCHAEUBLIN%20ADRIAN&rft.date=2020-07-24&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN111448317A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |