Chrysamide B derivative with anti-tumor activity and preparation and application of Chrysamide B derivative
The invention belongs to the field of medicinal chemistry, and particularly relates to a marine natural product Chrysamide B and a derivative thereof. The marine natural product Chrysamide B comprisesstereoisomers or pharmaceutically acceptable salts, solvates and prodrugs of the marine natural prod...
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| creator | ZHANG HONGHUA ZHU LONGQING SHI TAO FAN XIAOHONG LI JUNFANG TANG AIMIN WANG ZHEN |
| description | The invention belongs to the field of medicinal chemistry, and particularly relates to a marine natural product Chrysamide B and a derivative thereof. The marine natural product Chrysamide B comprisesstereoisomers or pharmaceutically acceptable salts, solvates and prodrugs of the marine natural product Chrysamide B, general formulas are shown in a formula (I), a formula (II) and a formula (III).The invention also provides preparation and application of the compound. The compound has an anti-cancer effect; the compound has good inhibitory activity on digestive system cancers, leukemia, livertumors, non-small cell lung cancers, cervical cancers, breast cancers and the like and has the effects of inducing tumor cell apoptosis, activating apoptosis protein expression, retarding cycle, inhibiting proliferation and the like and is a potential antitumor drug.
本发明属于药物化学领域，具体涉及一种海洋天然产物Chrysamide B及其衍生物，包括其立体异构体或药学上可接受的盐、溶剂化物和前药，通式为式（一）、式（二）和式（三），及所述化合物的制备和用途。本发明所述化合物具有抗癌作用，如对消化系统癌症、白血病、肝脏肿瘤、非小细胞肺癌、宫颈癌、乳腺癌等具有良好的抑制活性，并且 |
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本发明属于药物化学领域，具体涉及一种海洋天然产物Chrysamide B及其衍生物，包括其立体异构体或药学上可接受的盐、溶剂化物和前药，通式为式（一）、式（二）和式（三），及所述化合物的制备和用途。本发明所述化合物具有抗癌作用，如对消化系统癌症、白血病、肝脏肿瘤、非小细胞肺癌、宫颈癌、乳腺癌等具有良好的抑制活性，并且</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200724&DB=EPODOC&CC=CN&NR=111440155A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76419</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200724&DB=EPODOC&CC=CN&NR=111440155A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZHANG HONGHUA</creatorcontrib><creatorcontrib>ZHU LONGQING</creatorcontrib><creatorcontrib>SHI TAO</creatorcontrib><creatorcontrib>FAN XIAOHONG</creatorcontrib><creatorcontrib>LI JUNFANG</creatorcontrib><creatorcontrib>TANG AIMIN</creatorcontrib><creatorcontrib>WANG ZHEN</creatorcontrib><title>Chrysamide B derivative with anti-tumor activity and preparation and application of Chrysamide B derivative</title><description>The invention belongs to the field of medicinal chemistry, and particularly relates to a marine natural product Chrysamide B and a derivative thereof. The marine natural product Chrysamide B comprisesstereoisomers or pharmaceutically acceptable salts, solvates and prodrugs of the marine natural product Chrysamide B, general formulas are shown in a formula (I), a formula (II) and a formula (III).The invention also provides preparation and application of the compound. The compound has an anti-cancer effect; the compound has good inhibitory activity on digestive system cancers, leukemia, livertumors, non-small cell lung cancers, cervical cancers, breast cancers and the like and has the effects of inducing tumor cell apoptosis, activating apoptosis protein expression, retarding cycle, inhibiting proliferation and the like and is a potential antitumor drug.
本发明属于药物化学领域，具体涉及一种海洋天然产物Chrysamide B及其衍生物，包括其立体异构体或药学上可接受的盐、溶剂化物和前药，通式为式（一）、式（二）和式（三），及所述化合物的制备和用途。本发明所述化合物具有抗癌作用，如对消化系统癌症、白血病、肝脏肿瘤、非小细胞肺癌、宫颈癌、乳腺癌等具有良好的抑制活性，并且</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZMh2ziiqLE7MzUxJVXBSSEktyixLLMksS1UozyzJUEjMK8nULSnNzS9SSEwGCmeWVALFUhQKilILEouACvPzwPzEgoKczGQIPz9NAYeZPAysaYk5xam8UJqbQdHNNcTZQze1ID8-tbggMTk1L7Uk3tnP0NDQxMTA0NTU0ZgYNQDzp0GH</recordid><startdate>20200724</startdate><enddate>20200724</enddate><creator>ZHANG HONGHUA</creator><creator>ZHU LONGQING</creator><creator>SHI TAO</creator><creator>FAN XIAOHONG</creator><creator>LI JUNFANG</creator><creator>TANG AIMIN</creator><creator>WANG ZHEN</creator><scope>EVB</scope></search><sort><creationdate>20200724</creationdate><title>Chrysamide B derivative with anti-tumor activity and preparation and application of Chrysamide B derivative</title><author>ZHANG HONGHUA ; ZHU LONGQING ; SHI TAO ; FAN XIAOHONG ; LI JUNFANG ; TANG AIMIN ; WANG ZHEN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN111440155A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2020</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ZHANG HONGHUA</creatorcontrib><creatorcontrib>ZHU LONGQING</creatorcontrib><creatorcontrib>SHI TAO</creatorcontrib><creatorcontrib>FAN XIAOHONG</creatorcontrib><creatorcontrib>LI JUNFANG</creatorcontrib><creatorcontrib>TANG AIMIN</creatorcontrib><creatorcontrib>WANG ZHEN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZHANG HONGHUA</au><au>ZHU LONGQING</au><au>SHI TAO</au><au>FAN XIAOHONG</au><au>LI JUNFANG</au><au>TANG AIMIN</au><au>WANG ZHEN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Chrysamide B derivative with anti-tumor activity and preparation and application of Chrysamide B derivative</title><date>2020-07-24</date><risdate>2020</risdate><abstract>The invention belongs to the field of medicinal chemistry, and particularly relates to a marine natural product Chrysamide B and a derivative thereof. The marine natural product Chrysamide B comprisesstereoisomers or pharmaceutically acceptable salts, solvates and prodrugs of the marine natural product Chrysamide B, general formulas are shown in a formula (I), a formula (II) and a formula (III).The invention also provides preparation and application of the compound. The compound has an anti-cancer effect; the compound has good inhibitory activity on digestive system cancers, leukemia, livertumors, non-small cell lung cancers, cervical cancers, breast cancers and the like and has the effects of inducing tumor cell apoptosis, activating apoptosis protein expression, retarding cycle, inhibiting proliferation and the like and is a potential antitumor drug.
本发明属于药物化学领域，具体涉及一种海洋天然产物Chrysamide B及其衍生物，包括其立体异构体或药学上可接受的盐、溶剂化物和前药，通式为式（一）、式（二）和式（三），及所述化合物的制备和用途。本发明所述化合物具有抗癌作用，如对消化系统癌症、白血病、肝脏肿瘤、非小细胞肺癌、宫颈癌、乳腺癌等具有良好的抑制活性，并且</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Chrysamide B derivative with anti-tumor activity and preparation and application of Chrysamide B derivative |
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