盐酸咪达普利片剂及其制备方法
本发明公开了一种盐酸咪达普利片剂及其制备方法。该盐酸咪达普利片剂，其原料包括下述质量份的物质：盐酸咪达普利10份、乳糖70-74份、聚乙二醇6000 7-8份、硬脂酸镁0.4-0.5份。所述盐酸咪达普利的粒径D90≤30μm；所述乳糖是型号为200目的乳糖与乳糖T80按照质量比4:1-2的混合物。制备方法如下：将质量40-50％的乳糖、盐酸咪达普利、剩余量的乳糖，依次倒入湿法混合制粒机中混匀；加入聚乙二醇6000的水溶液制软材；制粒；使用流化床进行颗粒干燥、整粒；将硬脂酸镁与干燥颗粒共置于三维运动混合机中混合均匀，压片。本发明制备的盐酸咪达普利片剂与传统制片方法制得的片剂相比，药品含量均匀度显...
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| description | 本发明公开了一种盐酸咪达普利片剂及其制备方法。该盐酸咪达普利片剂，其原料包括下述质量份的物质：盐酸咪达普利10份、乳糖70-74份、聚乙二醇6000 7-8份、硬脂酸镁0.4-0.5份。所述盐酸咪达普利的粒径D90≤30μm；所述乳糖是型号为200目的乳糖与乳糖T80按照质量比4:1-2的混合物。制备方法如下：将质量40-50％的乳糖、盐酸咪达普利、剩余量的乳糖，依次倒入湿法混合制粒机中混匀；加入聚乙二醇6000的水溶液制软材；制粒；使用流化床进行颗粒干燥、整粒；将硬脂酸镁与干燥颗粒共置于三维运动混合机中混合均匀，压片。本发明制备的盐酸咪达普利片剂与传统制片方法制得的片剂相比，药品含量均匀度显著提高，溶出效果更好，产品质量更高。
The invention discloses an imidapril hydrochloride tablet and a preparation method thereof. The imidapril hydrochloride tablet is prepared from the following substances in parts by weight: 10 parts ofimidapril hydrochloride, 70 to 74 parts of lactose, 7 to 8 parts of polyethylene glycol 6000 and 0.4 to 0.5 part of magnesium stearate. The particle size D90 of the midapril hydrochloride is less than or equal to 30 microns; and the lactose is a mixture of lactose with the model of 200 meshes and lactose T80 according to the mass ratio of 4: (1-2). The preparation method comprises the steps of sequentially pouring 40-50% by mass of lactose, imidapril hydrochloride and the balance of lactose into a we |
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The invention discloses an imidapril hydrochloride tablet and a preparation method thereof. The imidapril hydrochloride tablet is prepared from the following substances in parts by weight: 10 parts ofimidapril hydrochloride, 70 to 74 parts of lactose, 7 to 8 parts of polyethylene glycol 6000 and 0.4 to 0.5 part of magnesium stearate. The particle size D90 of the midapril hydrochloride is less than or equal to 30 microns; and the lactose is a mixture of lactose with the model of 200 meshes and lactose T80 according to the mass ratio of 4: (1-2). The preparation method comprises the steps of sequentially pouring 40-50% by mass of lactose, imidapril hydrochloride and the balance of lactose into a we</description><language>chi</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210209&DB=EPODOC&CC=CN&NR=111329840B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210209&DB=EPODOC&CC=CN&NR=111329840B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><title>盐酸咪达普利片剂及其制备方法</title><description>本发明公开了一种盐酸咪达普利片剂及其制备方法。该盐酸咪达普利片剂，其原料包括下述质量份的物质：盐酸咪达普利10份、乳糖70-74份、聚乙二醇6000 7-8份、硬脂酸镁0.4-0.5份。所述盐酸咪达普利的粒径D90≤30μm；所述乳糖是型号为200目的乳糖与乳糖T80按照质量比4:1-2的混合物。制备方法如下：将质量40-50％的乳糖、盐酸咪达普利、剩余量的乳糖，依次倒入湿法混合制粒机中混匀；加入聚乙二醇6000的水溶液制软材；制粒；使用流化床进行颗粒干燥、整粒；将硬脂酸镁与干燥颗粒共置于三维运动混合机中混合均匀，压片。本发明制备的盐酸咪达普利片剂与传统制片方法制得的片剂相比，药品含量均匀度显著提高，溶出效果更好，产品质量更高。
The invention discloses an imidapril hydrochloride tablet and a preparation method thereof. The imidapril hydrochloride tablet is prepared from the following substances in parts by weight: 10 parts ofimidapril hydrochloride, 70 to 74 parts of lactose, 7 to 8 parts of polyethylene glycol 6000 and 0.4 to 0.5 part of magnesium stearate. The particle size D90 of the midapril hydrochloride is less than or equal to 30 microns; and the lactose is a mixture of lactose with the model of 200 meshes and lactose T80 according to the mass ratio of 4: (1-2). The preparation method comprises the steps of sequentially pouring 40-50% by mass of lactose, imidapril hydrochloride and the balance of lactose into a we</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNB6PnvCy9YdTyeterFv37OZ6552rHze2f60s-lpf9fT1m1PO7Y9XdL-bNrOZ5un8jCwpiXmFKfyQmluBiU31xBnD93Ugvz41OKCxOTUvNSSeGc_Q0NDYyNLCxMDJydjohQBAHpwNy4</recordid><startdate>20210209</startdate><enddate>20210209</enddate><scope>EVB</scope></search><sort><creationdate>20210209</creationdate><title>盐酸咪达普利片剂及其制备方法</title></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN111329840BB3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi</language><creationdate>2021</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>盐酸咪达普利片剂及其制备方法</title><date>2021-02-09</date><risdate>2021</risdate><abstract>本发明公开了一种盐酸咪达普利片剂及其制备方法。该盐酸咪达普利片剂，其原料包括下述质量份的物质：盐酸咪达普利10份、乳糖70-74份、聚乙二醇6000 7-8份、硬脂酸镁0.4-0.5份。所述盐酸咪达普利的粒径D90≤30μm；所述乳糖是型号为200目的乳糖与乳糖T80按照质量比4:1-2的混合物。制备方法如下：将质量40-50％的乳糖、盐酸咪达普利、剩余量的乳糖，依次倒入湿法混合制粒机中混匀；加入聚乙二醇6000的水溶液制软材；制粒；使用流化床进行颗粒干燥、整粒；将硬脂酸镁与干燥颗粒共置于三维运动混合机中混合均匀，压片。本发明制备的盐酸咪达普利片剂与传统制片方法制得的片剂相比，药品含量均匀度显著提高，溶出效果更好，产品质量更高。
The invention discloses an imidapril hydrochloride tablet and a preparation method thereof. The imidapril hydrochloride tablet is prepared from the following substances in parts by weight: 10 parts ofimidapril hydrochloride, 70 to 74 parts of lactose, 7 to 8 parts of polyethylene glycol 6000 and 0.4 to 0.5 part of magnesium stearate. The particle size D90 of the midapril hydrochloride is less than or equal to 30 microns; and the lactose is a mixture of lactose with the model of 200 meshes and lactose T80 according to the mass ratio of 4: (1-2). The preparation method comprises the steps of sequentially pouring 40-50% by mass of lactose, imidapril hydrochloride and the balance of lactose into a we</abstract><oa>free_for_read</oa></addata></record> |
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| title | 盐酸咪达普利片剂及其制备方法 |
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