Drug carrying microsphere with tumor chemoradiotherapy synergistic sensitization effect and preparation method thereof

The invention provides a drug carrying microsphere with a tumor chemoradiotherapy synergistic sensitization effect and a preparation method thereof. The method comprises the following steps: carryingout amidation reaction on a polyacrylic acid PAA and polyethylene glycol PEG with two end amination under action of a first activating agent to obtain a PAA-PEG block polymer; carrying out esterification reaction on the PAA-PEG block polymer and 1-ethoxy-2-methyl-5-nitroimidazole MN under the action of a second activating agent to obtain a MN-PAA-PEG polymer microsphere; and carrying out self-assembly on the MN-PAA-PEG polymer and doxorubicin DOX to obtain a doxorubicin-loaded DOX/MN-PAA-PEG microsphere. The drug carrying microsphere can be obtained only through three steps of an acylation reaction, an esterification reaction and self-assembly, the method has characteristics of a simple process, mild reaction conditions and easiness in operation. 本发明提供了一种具有肿瘤放化疗协同增敏效应的载药微球及其制备方法。所述方法包括：聚丙烯酸PAA与两端氨基化的聚乙二醇PEG，在第一活化剂