Oxytocin injection taking ethanol as chlorobutanol solvent and preparation method of oxytocin injection
The invention provides oxytocin injection taking ethanol as a chlorobutanol solvent. The oxytocin injection is prepared from the following raw materials and auxiliary materials in parts by weight andvolume: 5000 to 10000 parts of oxytocin, 2 to 9 parts of chlorobutanol, 2 to 6 parts of ethanol, 0.6...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | SHI LINGYANG SONG YONGHONG YANG FANG |
| description | The invention provides oxytocin injection taking ethanol as a chlorobutanol solvent. The oxytocin injection is prepared from the following raw materials and auxiliary materials in parts by weight andvolume: 5000 to 10000 parts of oxytocin, 2 to 9 parts of chlorobutanol, 2 to 6 parts of ethanol, 0.6 to 1.2 parts of sodium acetate and 1000 parts of water. The oxytocin injection is uniform in titerdistribution and high in stability within the validity period. The invention further provides a preparation method of the oxytocin injection taking the ethanol as the chlorobutanol solvent, the chlorobutanol is dissolved in the ethanol and then mixed with oxytocin and water, so that chlorobutanol in the injection is more stable, oxytocin distribution is more uniform, and the injection has practical application and popularization value.
本发明提供了一种以乙醇作为三氯叔丁醇溶剂的缩宫素注射液，它是由如下重量体积份的原辅料组成：缩宫素5000～10000份，三氯叔丁醇2～9份，乙醇2～6份，醋酸钠0.6～1.2份，水1000份。本发明缩宫素注射效价分布均匀，在有效期内稳定性高。本发明还提供了一种以乙醇作为三氯叔丁醇溶剂的缩宫素注射液的制备方法，通过先将三氯叔丁醇溶解在乙醇中，再与缩宫素和水混合，使注射液中 |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN111249231A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN111249231A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN111249231A3</originalsourceid><addsrcrecordid>eNqNjDEOwjAMRbMwIOAO5gAMaVkYUQVigoW9MqnbpgQ7SgyC24MqNhamLz2996emOz1fKs4zeB7IqRcGxavnDkh7ZAmAGVwfJMnlriPIEh7ECsgNxEQRE47d7VNIA9KC_JzOzaTFkGnx3ZlZ7nfn6rCiKDXliI6YtK6O1tpivSlKuy3_cd5bzEEQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Oxytocin injection taking ethanol as chlorobutanol solvent and preparation method of oxytocin injection</title><source>esp@cenet</source><creator>SHI LINGYANG ; SONG YONGHONG ; YANG FANG</creator><creatorcontrib>SHI LINGYANG ; SONG YONGHONG ; YANG FANG</creatorcontrib><description>The invention provides oxytocin injection taking ethanol as a chlorobutanol solvent. The oxytocin injection is prepared from the following raw materials and auxiliary materials in parts by weight andvolume: 5000 to 10000 parts of oxytocin, 2 to 9 parts of chlorobutanol, 2 to 6 parts of ethanol, 0.6 to 1.2 parts of sodium acetate and 1000 parts of water. The oxytocin injection is uniform in titerdistribution and high in stability within the validity period. The invention further provides a preparation method of the oxytocin injection taking the ethanol as the chlorobutanol solvent, the chlorobutanol is dissolved in the ethanol and then mixed with oxytocin and water, so that chlorobutanol in the injection is more stable, oxytocin distribution is more uniform, and the injection has practical application and popularization value.
本发明提供了一种以乙醇作为三氯叔丁醇溶剂的缩宫素注射液，它是由如下重量体积份的原辅料组成：缩宫素5000～10000份，三氯叔丁醇2～9份，乙醇2～6份，醋酸钠0.6～1.2份，水1000份。本发明缩宫素注射效价分布均匀，在有效期内稳定性高。本发明还提供了一种以乙醇作为三氯叔丁醇溶剂的缩宫素注射液的制备方法，通过先将三氯叔丁醇溶解在乙醇中，再与缩宫素和水混合，使注射液中</description><language>chi ; eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200609&DB=EPODOC&CC=CN&NR=111249231A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200609&DB=EPODOC&CC=CN&NR=111249231A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SHI LINGYANG</creatorcontrib><creatorcontrib>SONG YONGHONG</creatorcontrib><creatorcontrib>YANG FANG</creatorcontrib><title>Oxytocin injection taking ethanol as chlorobutanol solvent and preparation method of oxytocin injection</title><description>The invention provides oxytocin injection taking ethanol as a chlorobutanol solvent. The oxytocin injection is prepared from the following raw materials and auxiliary materials in parts by weight andvolume: 5000 to 10000 parts of oxytocin, 2 to 9 parts of chlorobutanol, 2 to 6 parts of ethanol, 0.6 to 1.2 parts of sodium acetate and 1000 parts of water. The oxytocin injection is uniform in titerdistribution and high in stability within the validity period. The invention further provides a preparation method of the oxytocin injection taking the ethanol as the chlorobutanol solvent, the chlorobutanol is dissolved in the ethanol and then mixed with oxytocin and water, so that chlorobutanol in the injection is more stable, oxytocin distribution is more uniform, and the injection has practical application and popularization value.
本发明提供了一种以乙醇作为三氯叔丁醇溶剂的缩宫素注射液，它是由如下重量体积份的原辅料组成：缩宫素5000～10000份，三氯叔丁醇2～9份，乙醇2～6份，醋酸钠0.6～1.2份，水1000份。本发明缩宫素注射效价分布均匀，在有效期内稳定性高。本发明还提供了一种以乙醇作为三氯叔丁醇溶剂的缩宫素注射液的制备方法，通过先将三氯叔丁醇溶解在乙醇中，再与缩宫素和水混合，使注射液中</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjDEOwjAMRbMwIOAO5gAMaVkYUQVigoW9MqnbpgQ7SgyC24MqNhamLz2996emOz1fKs4zeB7IqRcGxavnDkh7ZAmAGVwfJMnlriPIEh7ECsgNxEQRE47d7VNIA9KC_JzOzaTFkGnx3ZlZ7nfn6rCiKDXliI6YtK6O1tpivSlKuy3_cd5bzEEQ</recordid><startdate>20200609</startdate><enddate>20200609</enddate><creator>SHI LINGYANG</creator><creator>SONG YONGHONG</creator><creator>YANG FANG</creator><scope>EVB</scope></search><sort><creationdate>20200609</creationdate><title>Oxytocin injection taking ethanol as chlorobutanol solvent and preparation method of oxytocin injection</title><author>SHI LINGYANG ; SONG YONGHONG ; YANG FANG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN111249231A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2020</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SHI LINGYANG</creatorcontrib><creatorcontrib>SONG YONGHONG</creatorcontrib><creatorcontrib>YANG FANG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SHI LINGYANG</au><au>SONG YONGHONG</au><au>YANG FANG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Oxytocin injection taking ethanol as chlorobutanol solvent and preparation method of oxytocin injection</title><date>2020-06-09</date><risdate>2020</risdate><abstract>The invention provides oxytocin injection taking ethanol as a chlorobutanol solvent. The oxytocin injection is prepared from the following raw materials and auxiliary materials in parts by weight andvolume: 5000 to 10000 parts of oxytocin, 2 to 9 parts of chlorobutanol, 2 to 6 parts of ethanol, 0.6 to 1.2 parts of sodium acetate and 1000 parts of water. The oxytocin injection is uniform in titerdistribution and high in stability within the validity period. The invention further provides a preparation method of the oxytocin injection taking the ethanol as the chlorobutanol solvent, the chlorobutanol is dissolved in the ethanol and then mixed with oxytocin and water, so that chlorobutanol in the injection is more stable, oxytocin distribution is more uniform, and the injection has practical application and popularization value.
本发明提供了一种以乙醇作为三氯叔丁醇溶剂的缩宫素注射液，它是由如下重量体积份的原辅料组成：缩宫素5000～10000份，三氯叔丁醇2～9份，乙醇2～6份，醋酸钠0.6～1.2份，水1000份。本发明缩宫素注射效价分布均匀，在有效期内稳定性高。本发明还提供了一种以乙醇作为三氯叔丁醇溶剂的缩宫素注射液的制备方法，通过先将三氯叔丁醇溶解在乙醇中，再与缩宫素和水混合，使注射液中</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_CN111249231A |
| source | esp@cenet |
| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Oxytocin injection taking ethanol as chlorobutanol solvent and preparation method of oxytocin injection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T13%3A33%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=SHI%20LINGYANG&rft.date=2020-06-09&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN111249231A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |