HYDROXYCHLOROQUINE SULFATE FORMULATIONS AND METHODS FOR PREPARATION AND USE THEREOF

Water-dispersible pharmaceutical compositions of hydroxychloroquine sulfate in powder or granule form are provided that allow for ease of preparation of measured-dose, liquid suspensions that are palatable and suitable for pediatric administration. The compositions in granular or powder form are efficiently dissolvable in water and can be provided encapsulated within a two-piece releasable hard capsule or a packet or pouch for easy release. An ion-pairing agent is present in the formulation of the composition that masks the bitter taste of the hydroxychloroquine sulfate, significantly reducingthe need for addition of a sweetening agent. Methods are provided for preparing the water-dispersible pharmaceutical compositions of hydroxychloroquine sulfate and for preparing palatable weight-based pediatric doses. 提供了呈粉末或颗粒形式的硫酸羟基氯喹的水分散性药物组合物，其允许容易地制备可口并且适于儿科施用的测量剂量的液体混悬剂。呈颗粒或粉末形式的组合物有效地可溶于水，并且可以提供为被包封在两件式可释放硬胶囊或包或袋中以便易于释放。在组合物的制剂中存在离子配对试剂，其掩蔽了硫酸羟基氯喹的苦味，显著减少了添加甜味剂的需要。提供了用于制备硫酸羟基氯喹的水分散性药物组合物和用于制备可口的基于体重的小儿剂量的方法。