Method for preparing (R)-(+)-N-acetyl-1-methyl-3-amphetamine at high temperature
The invention discloses a method for preparing (R)-(+)-N-acetyl-1-methyl-3-amphetamine at a high temperature. The method comprises the following steps: by taking 1-methyl-3-amphetamine as a substrateand immobilized lipase Novozym435 as a catalyst, adding an organic solvent and an acylation reagent,...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | LIU BO LU YUAN TANG LAN OU ZHIMIN DAI HONGQIAN DU LIHUA |
| description | The invention discloses a method for preparing (R)-(+)-N-acetyl-1-methyl-3-amphetamine at a high temperature. The method comprises the following steps: by taking 1-methyl-3-amphetamine as a substrateand immobilized lipase Novozym435 as a catalyst, adding an organic solvent and an acylation reagent, and carrying out resolution reaction for 2-10 hours under the magnetic stirring conditions of 40-80DEG C and 1000rpm; and after the reaction is finished, separating and purifying a reaction solution to obtain (R)-(+)-N-acetyl-1-methyl-3-amphetamine. The substrate in the reaction provided by the invention achieves a conversion rate of 35.6% (the highest resolution reaction conversion rate is 50%) only in 4 hours, and the ee value of the R-configuration product achieves 98.3%. The used lipase isgranular immobilized lipase, and can be easily and quickly separated from the reaction solution.
本发明公开了一种高温下制备(R)-(+)-N-乙酰基-1-甲基-3-苯丙胺的方法，所述方法为：以1-甲基-3-苯丙胺为底物，以固定化脂肪酶Novozym435为催化剂，加入有机溶剂和酰化试剂，在40-80℃、1000rpm磁力搅拌条件下拆分反应2-10h，反 |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN111041015A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN111041015A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN111041015A3</originalsourceid><addsrcrecordid>eNqNjDEKwkAQANNYiPqHs0uQhSzRB0hQbAwi9mHRTe4gd7dc1sLfe4UPsJophlkWtyurjS8zxGQksVByYTTlvYJyV0EH9GT9TIDgc5elAfJiWcm7wIbUWDdao-yFE-k78bpYDDTNvPlxVWzPp0d7AZbY8yx5GFj7tkPEeo81Ho7NP80XZXQ1EA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Method for preparing (R)-(+)-N-acetyl-1-methyl-3-amphetamine at high temperature</title><source>esp@cenet</source><creator>LIU BO ; LU YUAN ; TANG LAN ; OU ZHIMIN ; DAI HONGQIAN ; DU LIHUA</creator><creatorcontrib>LIU BO ; LU YUAN ; TANG LAN ; OU ZHIMIN ; DAI HONGQIAN ; DU LIHUA</creatorcontrib><description>The invention discloses a method for preparing (R)-(+)-N-acetyl-1-methyl-3-amphetamine at a high temperature. The method comprises the following steps: by taking 1-methyl-3-amphetamine as a substrateand immobilized lipase Novozym435 as a catalyst, adding an organic solvent and an acylation reagent, and carrying out resolution reaction for 2-10 hours under the magnetic stirring conditions of 40-80DEG C and 1000rpm; and after the reaction is finished, separating and purifying a reaction solution to obtain (R)-(+)-N-acetyl-1-methyl-3-amphetamine. The substrate in the reaction provided by the invention achieves a conversion rate of 35.6% (the highest resolution reaction conversion rate is 50%) only in 4 hours, and the ee value of the R-configuration product achieves 98.3%. The used lipase isgranular immobilized lipase, and can be easily and quickly separated from the reaction solution.
本发明公开了一种高温下制备(R)-(+)-N-乙酰基-1-甲基-3-苯丙胺的方法，所述方法为：以1-甲基-3-苯丙胺为底物，以固定化脂肪酶Novozym435为催化剂，加入有机溶剂和酰化试剂，在40-80℃、1000rpm磁力搅拌条件下拆分反应2-10h，反</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200421&DB=EPODOC&CC=CN&NR=111041015A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200421&DB=EPODOC&CC=CN&NR=111041015A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LIU BO</creatorcontrib><creatorcontrib>LU YUAN</creatorcontrib><creatorcontrib>TANG LAN</creatorcontrib><creatorcontrib>OU ZHIMIN</creatorcontrib><creatorcontrib>DAI HONGQIAN</creatorcontrib><creatorcontrib>DU LIHUA</creatorcontrib><title>Method for preparing (R)-(+)-N-acetyl-1-methyl-3-amphetamine at high temperature</title><description>The invention discloses a method for preparing (R)-(+)-N-acetyl-1-methyl-3-amphetamine at a high temperature. The method comprises the following steps: by taking 1-methyl-3-amphetamine as a substrateand immobilized lipase Novozym435 as a catalyst, adding an organic solvent and an acylation reagent, and carrying out resolution reaction for 2-10 hours under the magnetic stirring conditions of 40-80DEG C and 1000rpm; and after the reaction is finished, separating and purifying a reaction solution to obtain (R)-(+)-N-acetyl-1-methyl-3-amphetamine. The substrate in the reaction provided by the invention achieves a conversion rate of 35.6% (the highest resolution reaction conversion rate is 50%) only in 4 hours, and the ee value of the R-configuration product achieves 98.3%. The used lipase isgranular immobilized lipase, and can be easily and quickly separated from the reaction solution.
本发明公开了一种高温下制备(R)-(+)-N-乙酰基-1-甲基-3-苯丙胺的方法，所述方法为：以1-甲基-3-苯丙胺为底物，以固定化脂肪酶Novozym435为催化剂，加入有机溶剂和酰化试剂，在40-80℃、1000rpm磁力搅拌条件下拆分反应2-10h，反</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjDEKwkAQANNYiPqHs0uQhSzRB0hQbAwi9mHRTe4gd7dc1sLfe4UPsJophlkWtyurjS8zxGQksVByYTTlvYJyV0EH9GT9TIDgc5elAfJiWcm7wIbUWDdao-yFE-k78bpYDDTNvPlxVWzPp0d7AZbY8yx5GFj7tkPEeo81Ho7NP80XZXQ1EA</recordid><startdate>20200421</startdate><enddate>20200421</enddate><creator>LIU BO</creator><creator>LU YUAN</creator><creator>TANG LAN</creator><creator>OU ZHIMIN</creator><creator>DAI HONGQIAN</creator><creator>DU LIHUA</creator><scope>EVB</scope></search><sort><creationdate>20200421</creationdate><title>Method for preparing (R)-(+)-N-acetyl-1-methyl-3-amphetamine at high temperature</title><author>LIU BO ; LU YUAN ; TANG LAN ; OU ZHIMIN ; DAI HONGQIAN ; DU LIHUA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN111041015A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2020</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>LIU BO</creatorcontrib><creatorcontrib>LU YUAN</creatorcontrib><creatorcontrib>TANG LAN</creatorcontrib><creatorcontrib>OU ZHIMIN</creatorcontrib><creatorcontrib>DAI HONGQIAN</creatorcontrib><creatorcontrib>DU LIHUA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LIU BO</au><au>LU YUAN</au><au>TANG LAN</au><au>OU ZHIMIN</au><au>DAI HONGQIAN</au><au>DU LIHUA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Method for preparing (R)-(+)-N-acetyl-1-methyl-3-amphetamine at high temperature</title><date>2020-04-21</date><risdate>2020</risdate><abstract>The invention discloses a method for preparing (R)-(+)-N-acetyl-1-methyl-3-amphetamine at a high temperature. The method comprises the following steps: by taking 1-methyl-3-amphetamine as a substrateand immobilized lipase Novozym435 as a catalyst, adding an organic solvent and an acylation reagent, and carrying out resolution reaction for 2-10 hours under the magnetic stirring conditions of 40-80DEG C and 1000rpm; and after the reaction is finished, separating and purifying a reaction solution to obtain (R)-(+)-N-acetyl-1-methyl-3-amphetamine. The substrate in the reaction provided by the invention achieves a conversion rate of 35.6% (the highest resolution reaction conversion rate is 50%) only in 4 hours, and the ee value of the R-configuration product achieves 98.3%. The used lipase isgranular immobilized lipase, and can be easily and quickly separated from the reaction solution.
本发明公开了一种高温下制备(R)-(+)-N-乙酰基-1-甲基-3-苯丙胺的方法，所述方法为：以1-甲基-3-苯丙胺为底物，以固定化脂肪酶Novozym435为催化剂，加入有机溶剂和酰化试剂，在40-80℃、1000rpm磁力搅拌条件下拆分反应2-10h，反</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_CN111041015A |
| source | esp@cenet |
| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | Method for preparing (R)-(+)-N-acetyl-1-methyl-3-amphetamine at high temperature |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T05%3A30%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=LIU%20BO&rft.date=2020-04-21&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN111041015A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |