Steroid derivative and preparation method thereof

The present invention relates to a steroid derivative and a preparation method thereof. The molecular structure of chlorambucil is improved on the basis of chlorambucil, the excellent anticancer curative effect of the core structure of chlorambucil is combined with the branched chain structure of a steroid parent nucleus with a good physiological activity effect to form a unique novel targeted anti-leukemia drug with a novel structure; when the steroid derivative is used for preparing an antitumor drug, the synthesis process and the preparation process are optimized, so the solvent consumptionis reduced, and the environment is protected; and the prepared drug reduces the clinical potential safety hazard. 本发明涉及一种类固醇衍生物，以及该类固醇衍生物的制备方法。本发明通过在苯丁酸氮芥基础上将其分子结构进行改进，将苯丁酸氮芥核心结构的优越抗癌疗效与具有较好生理活性作用的类固醇母核的支链结构相结合，形成独特的新型靶向的抗白血病药物，结构新颖；其在制备治疗抗肿瘤药物时，合成工艺与制剂工艺得到了优化，减少了溶剂用量，保护环境；制成的药物减少了临床的不安全隐患。