Method for synthesizing pyrrolidinyl diaminopyrimidine nitrogen oxide
The invention discloses a preparation method of pyrrolidinyl diaminopyrimidine nitrogen oxide, and belongs to the technical field of organic synthesis. 2,4-diamino-6-chloropyrimidine used as a raw material undergoes continuous amination and oxidation reactions to obtain the pyrrolidinyl diaminopyrim...
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| creator | ZHANG KELUN ZHANG TAIJUN |
| description | The invention discloses a preparation method of pyrrolidinyl diaminopyrimidine nitrogen oxide, and belongs to the technical field of organic synthesis. 2,4-diamino-6-chloropyrimidine used as a raw material undergoes continuous amination and oxidation reactions to obtain the pyrrolidinyl diaminopyrimidine nitrogen oxide. The preparation method comprises the following steps: firstly, performing nucleophilic substitution amination on 2,4-diamino-6-chloropyrimidine and tetrahydropyrrole in the presence of an alkali, and performing acid quenching to obtain an acidic aqueous solution; and dropwise adding hydrogen peroxide for oxidation in the presence of sodium tungstate, and then performing alkali neutralization to obtain pyrrolidinyl diaminopyrimidine nitrogen oxide. The method is simple and convenient to operate, mild in condition, low in cost and high in yield, the purity of the obtained product can reach 99.5% or above, and the method is suitable for large-scale production.
本发明公开了一种吡咯烷基二氨基嘧啶氮氧化物的制备方法，属于有机合成技术领 |
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本发明公开了一种吡咯烷基二氨基嘧啶氮氧化物的制备方法，属于有机合成技术领</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHD1TS3JyE9RSMsvUiiuzCvJSC3OrMrMS1coqCwqys_JTMnMq8xRSMlMzM3MyweKZeaChFIV8jJLivLTU_MU8isyU1J5GFjTEnOKU3mhNDeDoptriLOHbmpBfnxqcUFicmpeakm8s5-hoaGBoYWFsYWjMTFqAJf9NIw</recordid><startdate>20200417</startdate><enddate>20200417</enddate><creator>ZHANG KELUN</creator><creator>ZHANG TAIJUN</creator><scope>EVB</scope></search><sort><creationdate>20200417</creationdate><title>Method for synthesizing pyrrolidinyl diaminopyrimidine nitrogen oxide</title><author>ZHANG KELUN ; ZHANG TAIJUN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN111018838A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2020</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>ZHANG KELUN</creatorcontrib><creatorcontrib>ZHANG TAIJUN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZHANG KELUN</au><au>ZHANG TAIJUN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Method for synthesizing pyrrolidinyl diaminopyrimidine nitrogen oxide</title><date>2020-04-17</date><risdate>2020</risdate><abstract>The invention discloses a preparation method of pyrrolidinyl diaminopyrimidine nitrogen oxide, and belongs to the technical field of organic synthesis. 2,4-diamino-6-chloropyrimidine used as a raw material undergoes continuous amination and oxidation reactions to obtain the pyrrolidinyl diaminopyrimidine nitrogen oxide. The preparation method comprises the following steps: firstly, performing nucleophilic substitution amination on 2,4-diamino-6-chloropyrimidine and tetrahydropyrrole in the presence of an alkali, and performing acid quenching to obtain an acidic aqueous solution; and dropwise adding hydrogen peroxide for oxidation in the presence of sodium tungstate, and then performing alkali neutralization to obtain pyrrolidinyl diaminopyrimidine nitrogen oxide. The method is simple and convenient to operate, mild in condition, low in cost and high in yield, the purity of the obtained product can reach 99.5% or above, and the method is suitable for large-scale production.
本发明公开了一种吡咯烷基二氨基嘧啶氮氧化物的制备方法，属于有机合成技术领</abstract><oa>free_for_read</oa></addata></record> |
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| title | Method for synthesizing pyrrolidinyl diaminopyrimidine nitrogen oxide |
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