Preparation method of high-purity 3-phenoxypropyl bromide
The invention discloses a preparation method of aclidinium bromide key intermediate 3-phenoxypropyl bromide (formula I). The method comprises the following steps: by taking phenol and halogenated propanol as raw materials, carrying out nucleophilic substitution reaction under an alkaline condition t...
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| creator | CUI XINQIANG ZHANG ZONGLEI DUAN CHONGGANG ZHAO SITAI KONG XIANGYU ZHANG NING DENG YUXIAO YANG LI MA XINCHENG FENG GUANGLING FU BINGYUE SUN JINRUI REN YEMING LIU WENTAO |
| description | The invention discloses a preparation method of aclidinium bromide key intermediate 3-phenoxypropyl bromide (formula I). The method comprises the following steps: by taking phenol and halogenated propanol as raw materials, carrying out nucleophilic substitution reaction under an alkaline condition to generate 3-phenoxy propanol, then reacting with a sulfonic acid esterification reagent to generateactive ester of 3-phenoxy propanol, refining the ester, and then reacting with a bromide of an alkali metal to generate 3-phenoxypropyl bromide. The preparation method provided by the invention has the advantages of cheap and easily available raw materials, simple operation, mild reaction conditions, no harsh reaction conditions, and high yield and purity of the obtained product, and is suitablefor industrial production.
本发明公开了一种阿地溴铵关键中间体3-苯氧基溴丙烷（式I）的制备方法。该方法以苯酚和卤代丙醇为原料，在碱性条件下发生亲核取代反应生成3-苯氧基丙醇，然后与磺酸酯化试剂反应生成3-苯氧基丙醇的活性酯，该酯精制后与碱金属的溴化物反应生成3-苯氧基溴丙烷。本发明提供的的制备方法所用原料廉价易得，操作简单，反应条件温和，无苛刻反应条件，所得产品收率和纯度均很高，适合工业化生产。 |
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本发明公开了一种阿地溴铵关键中间体3-苯氧基溴丙烷（式I）的制备方法。该方法以苯酚和卤代丙醇为原料，在碱性条件下发生亲核取代反应生成3-苯氧基丙醇，然后与磺酸酯化试剂反应生成3-苯氧基丙醇的活性酯，该酯精制后与碱金属的溴化物反应生成3-苯氧基溴丙烷。本发明提供的的制备方法所用原料廉价易得，操作简单，反应条件温和，无苛刻反应条件，所得产品收率和纯度均很高，适合工业化生产。</description><language>chi ; eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200417&DB=EPODOC&CC=CN&NR=111018678A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25547,76298</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200417&DB=EPODOC&CC=CN&NR=111018678A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CUI XINQIANG</creatorcontrib><creatorcontrib>ZHANG ZONGLEI</creatorcontrib><creatorcontrib>DUAN CHONGGANG</creatorcontrib><creatorcontrib>ZHAO SITAI</creatorcontrib><creatorcontrib>KONG XIANGYU</creatorcontrib><creatorcontrib>ZHANG NING</creatorcontrib><creatorcontrib>DENG YUXIAO</creatorcontrib><creatorcontrib>YANG LI</creatorcontrib><creatorcontrib>MA XINCHENG</creatorcontrib><creatorcontrib>FENG GUANGLING</creatorcontrib><creatorcontrib>FU BINGYUE</creatorcontrib><creatorcontrib>SUN JINRUI</creatorcontrib><creatorcontrib>REN YEMING</creatorcontrib><creatorcontrib>LIU WENTAO</creatorcontrib><title>Preparation method of high-purity 3-phenoxypropyl bromide</title><description>The invention discloses a preparation method of aclidinium bromide key intermediate 3-phenoxypropyl bromide (formula I). The method comprises the following steps: by taking phenol and halogenated propanol as raw materials, carrying out nucleophilic substitution reaction under an alkaline condition to generate 3-phenoxy propanol, then reacting with a sulfonic acid esterification reagent to generateactive ester of 3-phenoxy propanol, refining the ester, and then reacting with a bromide of an alkali metal to generate 3-phenoxypropyl bromide. The preparation method provided by the invention has the advantages of cheap and easily available raw materials, simple operation, mild reaction conditions, no harsh reaction conditions, and high yield and purity of the obtained product, and is suitablefor industrial production.
本发明公开了一种阿地溴铵关键中间体3-苯氧基溴丙烷（式I）的制备方法。该方法以苯酚和卤代丙醇为原料，在碱性条件下发生亲核取代反应生成3-苯氧基丙醇，然后与磺酸酯化试剂反应生成3-苯氧基丙醇的活性酯，该酯精制后与碱金属的溴化物反应生成3-苯氧基溴丙烷。本发明提供的的制备方法所用原料廉价易得，操作简单，反应条件温和，无苛刻反应条件，所得产品收率和纯度均很高，适合工业化生产。</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAMKEotSCxKLMnMz1PITS3JyE9RyE9TyMhMz9AtKC3KLKlUMNYtyEjNy6-oLCjKL6jMUUgqys_NTEnlYWBNS8wpTuWF0twMim6uIc4euqkF-fGpxQWJyal5qSXxzn6GhoYGhhZm5haOxsSoAQBnLC8K</recordid><startdate>20200417</startdate><enddate>20200417</enddate><creator>CUI XINQIANG</creator><creator>ZHANG ZONGLEI</creator><creator>DUAN CHONGGANG</creator><creator>ZHAO SITAI</creator><creator>KONG XIANGYU</creator><creator>ZHANG NING</creator><creator>DENG YUXIAO</creator><creator>YANG LI</creator><creator>MA XINCHENG</creator><creator>FENG GUANGLING</creator><creator>FU BINGYUE</creator><creator>SUN JINRUI</creator><creator>REN YEMING</creator><creator>LIU WENTAO</creator><scope>EVB</scope></search><sort><creationdate>20200417</creationdate><title>Preparation method of high-purity 3-phenoxypropyl bromide</title><author>CUI XINQIANG ; ZHANG ZONGLEI ; DUAN CHONGGANG ; ZHAO SITAI ; KONG XIANGYU ; ZHANG NING ; DENG YUXIAO ; YANG LI ; MA XINCHENG ; FENG GUANGLING ; FU BINGYUE ; SUN JINRUI ; REN YEMING ; LIU WENTAO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN111018678A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2020</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>CUI XINQIANG</creatorcontrib><creatorcontrib>ZHANG ZONGLEI</creatorcontrib><creatorcontrib>DUAN CHONGGANG</creatorcontrib><creatorcontrib>ZHAO SITAI</creatorcontrib><creatorcontrib>KONG XIANGYU</creatorcontrib><creatorcontrib>ZHANG NING</creatorcontrib><creatorcontrib>DENG YUXIAO</creatorcontrib><creatorcontrib>YANG LI</creatorcontrib><creatorcontrib>MA XINCHENG</creatorcontrib><creatorcontrib>FENG GUANGLING</creatorcontrib><creatorcontrib>FU BINGYUE</creatorcontrib><creatorcontrib>SUN JINRUI</creatorcontrib><creatorcontrib>REN YEMING</creatorcontrib><creatorcontrib>LIU WENTAO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CUI XINQIANG</au><au>ZHANG ZONGLEI</au><au>DUAN CHONGGANG</au><au>ZHAO SITAI</au><au>KONG XIANGYU</au><au>ZHANG NING</au><au>DENG YUXIAO</au><au>YANG LI</au><au>MA XINCHENG</au><au>FENG GUANGLING</au><au>FU BINGYUE</au><au>SUN JINRUI</au><au>REN YEMING</au><au>LIU WENTAO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Preparation method of high-purity 3-phenoxypropyl bromide</title><date>2020-04-17</date><risdate>2020</risdate><abstract>The invention discloses a preparation method of aclidinium bromide key intermediate 3-phenoxypropyl bromide (formula I). The method comprises the following steps: by taking phenol and halogenated propanol as raw materials, carrying out nucleophilic substitution reaction under an alkaline condition to generate 3-phenoxy propanol, then reacting with a sulfonic acid esterification reagent to generateactive ester of 3-phenoxy propanol, refining the ester, and then reacting with a bromide of an alkali metal to generate 3-phenoxypropyl bromide. The preparation method provided by the invention has the advantages of cheap and easily available raw materials, simple operation, mild reaction conditions, no harsh reaction conditions, and high yield and purity of the obtained product, and is suitablefor industrial production.
本发明公开了一种阿地溴铵关键中间体3-苯氧基溴丙烷（式I）的制备方法。该方法以苯酚和卤代丙醇为原料，在碱性条件下发生亲核取代反应生成3-苯氧基丙醇，然后与磺酸酯化试剂反应生成3-苯氧基丙醇的活性酯，该酯精制后与碱金属的溴化物反应生成3-苯氧基溴丙烷。本发明提供的的制备方法所用原料廉价易得，操作简单，反应条件温和，无苛刻反应条件，所得产品收率和纯度均很高，适合工业化生产。</abstract><oa>free_for_read</oa></addata></record> |
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| title | Preparation method of high-purity 3-phenoxypropyl bromide |
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