Dabigatran etexilate pharmaceutical composition and preparation method thereof
The invention relates to a dabigatran etexilate pharmaceutical composition and a preparation method thereof. The dabigatran etexilate pharmaceutical composition comprises a pill I and a pill II, wherein the pill I contains an active ingredient, a blank pill core material, an adhesive, an anti-sticki...
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| creator | ZENG QIN LUO JIE JIANG ZHIYONG XIANG ZHIXIANG ZHOU SHICHUAN LI FANGQUN |
| description | The invention relates to a dabigatran etexilate pharmaceutical composition and a preparation method thereof. The dabigatran etexilate pharmaceutical composition comprises a pill I and a pill II, wherein the pill I contains an active ingredient, a blank pill core material, an adhesive, an anti-sticking agent and/or an isolation material, the active ingredient comprises dabigatran etexilate or a pharmaceutically acceptable salt, a hydrate or a solvate thereof, and the pill II contains a medicinal organic acid, a pill core material, an adhesive, an anti-sticking agent and/or an isolation material. According to the invention, the active ingredient and the organic acid are respectively contained in the two different pills, so that the dissolution requirement of the active ingredient is met, thedissolution is uniform, and the isolation effect of the active ingredient and the organic acid is enhanced so as to improve the stability of the preparation.
本发明涉及一种达比加群酯药物组合物及其制备方法。本发明的达比加群酯药物组合物包含丸I和丸II：所述丸I含活性成分与空白丸芯材料、粘合 |
| format | Patent |
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本发明涉及一种达比加群酯药物组合物及其制备方法。本发明的达比加群酯药物组合物包含丸I和丸II：所述丸I含活性成分与空白丸芯材料、粘合</description><language>chi ; eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200417&DB=EPODOC&CC=CN&NR=111012756A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200417&DB=EPODOC&CC=CN&NR=111012756A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZENG QIN</creatorcontrib><creatorcontrib>LUO JIE</creatorcontrib><creatorcontrib>JIANG ZHIYONG</creatorcontrib><creatorcontrib>XIANG ZHIXIANG</creatorcontrib><creatorcontrib>ZHOU SHICHUAN</creatorcontrib><creatorcontrib>LI FANGQUN</creatorcontrib><title>Dabigatran etexilate pharmaceutical composition and preparation method thereof</title><description>The invention relates to a dabigatran etexilate pharmaceutical composition and a preparation method thereof. The dabigatran etexilate pharmaceutical composition comprises a pill I and a pill II, wherein the pill I contains an active ingredient, a blank pill core material, an adhesive, an anti-sticking agent and/or an isolation material, the active ingredient comprises dabigatran etexilate or a pharmaceutically acceptable salt, a hydrate or a solvate thereof, and the pill II contains a medicinal organic acid, a pill core material, an adhesive, an anti-sticking agent and/or an isolation material. According to the invention, the active ingredient and the organic acid are respectively contained in the two different pills, so that the dissolution requirement of the active ingredient is met, thedissolution is uniform, and the isolation effect of the active ingredient and the organic acid is enhanced so as to improve the stability of the preparation.
本发明涉及一种达比加群酯药物组合物及其制备方法。本发明的达比加群酯药物组合物包含丸I和丸II：所述丸I含活性成分与空白丸芯材料、粘合</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjLEKAjEQBdNYiPoP8QMEo6i1nIrVVfbHmnvnBZLskqzg5yviB1gNA8NMTXuie3iQFsoWileIpLAyUknk8dTgKVrPSbgGDZwt5d5KgVChryfoyL3VEQU8zM1koFix-HFmlpfzrbmuINyhyueZoV3TOufWbnPY7Y_bf5o3kSA3dA</recordid><startdate>20200417</startdate><enddate>20200417</enddate><creator>ZENG QIN</creator><creator>LUO JIE</creator><creator>JIANG ZHIYONG</creator><creator>XIANG ZHIXIANG</creator><creator>ZHOU SHICHUAN</creator><creator>LI FANGQUN</creator><scope>EVB</scope></search><sort><creationdate>20200417</creationdate><title>Dabigatran etexilate pharmaceutical composition and preparation method thereof</title><author>ZENG QIN ; LUO JIE ; JIANG ZHIYONG ; XIANG ZHIXIANG ; ZHOU SHICHUAN ; LI FANGQUN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN111012756A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2020</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ZENG QIN</creatorcontrib><creatorcontrib>LUO JIE</creatorcontrib><creatorcontrib>JIANG ZHIYONG</creatorcontrib><creatorcontrib>XIANG ZHIXIANG</creatorcontrib><creatorcontrib>ZHOU SHICHUAN</creatorcontrib><creatorcontrib>LI FANGQUN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZENG QIN</au><au>LUO JIE</au><au>JIANG ZHIYONG</au><au>XIANG ZHIXIANG</au><au>ZHOU SHICHUAN</au><au>LI FANGQUN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Dabigatran etexilate pharmaceutical composition and preparation method thereof</title><date>2020-04-17</date><risdate>2020</risdate><abstract>The invention relates to a dabigatran etexilate pharmaceutical composition and a preparation method thereof. The dabigatran etexilate pharmaceutical composition comprises a pill I and a pill II, wherein the pill I contains an active ingredient, a blank pill core material, an adhesive, an anti-sticking agent and/or an isolation material, the active ingredient comprises dabigatran etexilate or a pharmaceutically acceptable salt, a hydrate or a solvate thereof, and the pill II contains a medicinal organic acid, a pill core material, an adhesive, an anti-sticking agent and/or an isolation material. According to the invention, the active ingredient and the organic acid are respectively contained in the two different pills, so that the dissolution requirement of the active ingredient is met, thedissolution is uniform, and the isolation effect of the active ingredient and the organic acid is enhanced so as to improve the stability of the preparation.
本发明涉及一种达比加群酯药物组合物及其制备方法。本发明的达比加群酯药物组合物包含丸I和丸II：所述丸I含活性成分与空白丸芯材料、粘合</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Dabigatran etexilate pharmaceutical composition and preparation method thereof |
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