IGF-1R MONOCLONAL ANTIBODIES AND USES THEREOF
The present invention relates to conjugates including a chelating moiety of a metal complex thereof and a therapeutic or targeting moiety, methods for their production, and uses thereof. The present invention is directed to monoclonal antibodies that target the insulin-like growth factor-1 receptor...
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| creator | SIMMS RYAN WAYNE FORBES JOHN RICHARD MORAN MATTHEW DAVID BURR VALLIANT JOHN FITZMAURICE BURAK ERIC STEVEN |
| description | The present invention relates to conjugates including a chelating moiety of a metal complex thereof and a therapeutic or targeting moiety, methods for their production, and uses thereof. The present invention is directed to monoclonal antibodies that target the insulin-like growth factor-1 receptor and the radioimmunoconjugates thereof that demonstrate increased potency and enhance the excretion of a chelating moiety, or a metal complex thereof, when conjugated to a therapeutic moiety, a targeting moiety, or a cross-linking group. In another aspect, the invention features a pharmaceutical composition comprising a compound of the invention; and a pharmaceutically acceptable excipient. In another aspect, the invention features a method of radiation treatment planning and/or radiation treatment, the method comprising administering to a subject in need thereof a compound or pharmaceutical composition of the invention.
本发明涉及包含螯合部分或其金属络合物和治疗或靶向部分的缀合物、其生产方法及其用途。本发明涉及靶向胰岛素样生长因子-1受体的单克隆抗体及其放射免疫缀合物，其表现出增强的效力，并当缀合至治疗部分、 |
| format | Patent |
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本发明涉及包含螯合部分或其金属络合物和治疗或靶向部分的缀合物、其生产方法及其用途。本发明涉及靶向胰岛素样生长因子-1受体的单克隆抗体及其放射免疫缀合物，其表现出增强的效力，并当缀合至治疗部分、</description><language>chi ; eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200317&DB=EPODOC&CC=CN&NR=110891614A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200317&DB=EPODOC&CC=CN&NR=110891614A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SIMMS RYAN WAYNE</creatorcontrib><creatorcontrib>FORBES JOHN RICHARD</creatorcontrib><creatorcontrib>MORAN MATTHEW DAVID BURR</creatorcontrib><creatorcontrib>VALLIANT JOHN FITZMAURICE</creatorcontrib><creatorcontrib>BURAK ERIC STEVEN</creatorcontrib><title>IGF-1R MONOCLONAL ANTIBODIES AND USES THEREOF</title><description>The present invention relates to conjugates including a chelating moiety of a metal complex thereof and a therapeutic or targeting moiety, methods for their production, and uses thereof. The present invention is directed to monoclonal antibodies that target the insulin-like growth factor-1 receptor and the radioimmunoconjugates thereof that demonstrate increased potency and enhance the excretion of a chelating moiety, or a metal complex thereof, when conjugated to a therapeutic moiety, a targeting moiety, or a cross-linking group. In another aspect, the invention features a pharmaceutical composition comprising a compound of the invention; and a pharmaceutically acceptable excipient. In another aspect, the invention features a method of radiation treatment planning and/or radiation treatment, the method comprising administering to a subject in need thereof a compound or pharmaceutical composition of the invention.
本发明涉及包含螯合部分或其金属络合物和治疗或靶向部分的缀合物、其生产方法及其用途。本发明涉及靶向胰岛素样生长因子-1受体的单克隆抗体及其放射免疫缀合物，其表现出增强的效力，并当缀合至治疗部分、</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZND1dHfTNQxS8PX383f28fdz9FFw9AvxdPJ38XQNBjJdFEKDgYwQD9cgV383HgbWtMSc4lReKM3NoOjmGuLsoZtakB-fWlyQmJyal1oS7-xnaGhgYWloZmjiaEyMGgCcZSUs</recordid><startdate>20200317</startdate><enddate>20200317</enddate><creator>SIMMS RYAN WAYNE</creator><creator>FORBES JOHN RICHARD</creator><creator>MORAN MATTHEW DAVID BURR</creator><creator>VALLIANT JOHN FITZMAURICE</creator><creator>BURAK ERIC STEVEN</creator><scope>EVB</scope></search><sort><creationdate>20200317</creationdate><title>IGF-1R MONOCLONAL ANTIBODIES AND USES THEREOF</title><author>SIMMS RYAN WAYNE ; FORBES JOHN RICHARD ; MORAN MATTHEW DAVID BURR ; VALLIANT JOHN FITZMAURICE ; BURAK ERIC STEVEN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN110891614A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2020</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SIMMS RYAN WAYNE</creatorcontrib><creatorcontrib>FORBES JOHN RICHARD</creatorcontrib><creatorcontrib>MORAN MATTHEW DAVID BURR</creatorcontrib><creatorcontrib>VALLIANT JOHN FITZMAURICE</creatorcontrib><creatorcontrib>BURAK ERIC STEVEN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SIMMS RYAN WAYNE</au><au>FORBES JOHN RICHARD</au><au>MORAN MATTHEW DAVID BURR</au><au>VALLIANT JOHN FITZMAURICE</au><au>BURAK ERIC STEVEN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>IGF-1R MONOCLONAL ANTIBODIES AND USES THEREOF</title><date>2020-03-17</date><risdate>2020</risdate><abstract>The present invention relates to conjugates including a chelating moiety of a metal complex thereof and a therapeutic or targeting moiety, methods for their production, and uses thereof. The present invention is directed to monoclonal antibodies that target the insulin-like growth factor-1 receptor and the radioimmunoconjugates thereof that demonstrate increased potency and enhance the excretion of a chelating moiety, or a metal complex thereof, when conjugated to a therapeutic moiety, a targeting moiety, or a cross-linking group. In another aspect, the invention features a pharmaceutical composition comprising a compound of the invention; and a pharmaceutically acceptable excipient. In another aspect, the invention features a method of radiation treatment planning and/or radiation treatment, the method comprising administering to a subject in need thereof a compound or pharmaceutical composition of the invention.
本发明涉及包含螯合部分或其金属络合物和治疗或靶向部分的缀合物、其生产方法及其用途。本发明涉及靶向胰岛素样生长因子-1受体的单克隆抗体及其放射免疫缀合物，其表现出增强的效力，并当缀合至治疗部分、</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | IGF-1R MONOCLONAL ANTIBODIES AND USES THEREOF |
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