Sitagliptin hydrochloride monohydrate crystal form preparation method

The invention relates to a sitagliptin hydrochloride monohydrate crystal form preparation method, wherein a dissolving solvent is a mixed solvent of an ester solvent and water, and the preparation method comprises: mixing dissolved sitagliptin, a hydrochloric acid/ester solvent and water, reacting, cooling, carrying out suction filtration, and drying. The preparation method of the crystal form canbe used for preparing the sitagliptin hydrochloride monohydrate crystal form with high yield and high purity. 本发明涉及一种西格列汀盐酸盐单水合物晶型的制备方法，所述溶解溶剂为酯类溶剂与水的混合溶剂，涉及将溶解的西格列汀，盐酸/酯类溶剂和水混合，反应完毕，冷却，抽滤，干燥后制备得到。这种晶型制备方法能够制备得到收率高纯度高的西格列汀盐酸盐单水合物晶型。