(Z)-4-trifluoromethyl-5-thio-alkyl-4-pentenone derivative and preparation method therefor
The invention discloses a (Z)-4-trifluoromethyl-5-thio-alkyl-4-pentenone derivative and a preparation method therefor. The method comprises the steps of adding and mixing alkyne thioether with a structure represented by a formula II, S-(trifluoromethyl)dibenzothiophene onium trifluoromethyl sulfonat...
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| creator | LUO FANG ZHU GANGGUO SHU CHENYUN ZHANG YAN SHANG TIANBO |
| description | The invention discloses a (Z)-4-trifluoromethyl-5-thio-alkyl-4-pentenone derivative and a preparation method therefor. The method comprises the steps of adding and mixing alkyne thioether with a structure represented by a formula II, S-(trifluoromethyl)dibenzothiophene onium trifluoromethyl sulfonate with a structure represented by a formula III, ruthenium tri(2,2-bipyridyl)dichloride, alkali anda solvent, forming a reaction system under blue-light irradiation, and carrying out aftertreatment after a reaction is completed, thereby obtaining the (Z)-4-trifluoromethyl-5-thio-alkyl-4-pentenone derivative with a structure represented by a formula I. According to the method, the stereoselective synthesis of the (Z)-4-trifluoromethyl-5-thio-alkyl-4-pentenone derivative is achieved in one step.The reaction conditions are mild, the substrate applicable range is broad, the reaction yield is good, the operation is simple, and a new way is provided for synthesis of trifluoromethyl containing pentenone compounds.
本发明公开了一 |
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本发明公开了一</description><language>chi ; eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; APPARATUS THEREFOR ; CHEMISTRY ; GENERAL METHODS OF ORGANIC CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200117&DB=EPODOC&CC=CN&NR=110698313A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200117&DB=EPODOC&CC=CN&NR=110698313A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LUO FANG</creatorcontrib><creatorcontrib>ZHU GANGGUO</creatorcontrib><creatorcontrib>SHU CHENYUN</creatorcontrib><creatorcontrib>ZHANG YAN</creatorcontrib><creatorcontrib>SHANG TIANBO</creatorcontrib><title>(Z)-4-trifluoromethyl-5-thio-alkyl-4-pentenone derivative and preparation method therefor</title><description>The invention discloses a (Z)-4-trifluoromethyl-5-thio-alkyl-4-pentenone derivative and a preparation method therefor. The method comprises the steps of adding and mixing alkyne thioether with a structure represented by a formula II, S-(trifluoromethyl)dibenzothiophene onium trifluoromethyl sulfonate with a structure represented by a formula III, ruthenium tri(2,2-bipyridyl)dichloride, alkali anda solvent, forming a reaction system under blue-light irradiation, and carrying out aftertreatment after a reaction is completed, thereby obtaining the (Z)-4-trifluoromethyl-5-thio-alkyl-4-pentenone derivative with a structure represented by a formula I. According to the method, the stereoselective synthesis of the (Z)-4-trifluoromethyl-5-thio-alkyl-4-pentenone derivative is achieved in one step.The reaction conditions are mild, the substrate applicable range is broad, the reaction yield is good, the operation is simple, and a new way is provided for synthesis of trifluoromethyl containing pentenone compounds.
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本发明公开了一</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY METALLURGY ORGANIC CHEMISTRY |
| title | (Z)-4-trifluoromethyl-5-thio-alkyl-4-pentenone derivative and preparation method therefor |
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