Genetic engineering subunit vaccine for preventing new variant of chicken infectious bursal disease virus and preparation method thereof

The invention provides a genetic engineering subunit vaccine for preventing a new variant of a chicken infectious bursal disease virus. The new variant is an IBDV FJ-1812 strain. The effective component of the genetic engineering subunit vaccine is VP2 protein expressed after codon optimization and transformation of the gene sequence of the variant, and a nucleotide sequence of the VP2 protein isshown as SEQ ID NO. 1; a genetically engineered bacterium with a VP2 protein expression region as shown in SEQ ID NO.1 of an IBDV FJ-1812 strain is constructed, and induced expression and purificationare carried out to obtain VP2 protein, and the VP2 protein with a pharmaceutically acceptable adjuvant are uniformly mixed to prepare the genetic engineering subunit vaccine of the IBDV new variant.According to the invention, the new variant IBDV FJ-1812 strain is discovered for the first time, an expression vector and engineering bacteria capable of expressing the VP2 protein are constructed for the variant, and the expr