ANTI-DR5 ANTIBODY AND USE THEREOF
The present invention relates to an antibody that specifically binds to death receptor 5 (DR5) and has a function of killing cancer cells. Specifically, provided are an anti-DR5 antibody or antigen-binding fragment thereof, and a use of the antibody or antigen-binding fragment for preventing or trea...
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| creator | KIM DONGHYEON SONG DONGSUP LEE DONGSOP HAN KYUNGMI KIM YOOJIN WOO SOYON JUNG EUNEE LEE HAN YOUNG DOH HYOUNMIE SHIN KUM-JOO |
| description | The present invention relates to an antibody that specifically binds to death receptor 5 (DR5) and has a function of killing cancer cells. Specifically, provided are an anti-DR5 antibody or antigen-binding fragment thereof, and a use of the antibody or antigen-binding fragment for preventing or treating cancer. The present invention is characterized in that the anti-DR5 antibody or antigen-bindingfragment thereof is improved in terms of affinity to DR5, stability, and an effect of killing cancer cells.
本发明涉及与死亡受体5(DR5)特异性结合并具有杀伤癌细胞功能的抗体。更具体地，提供了抗DR5抗体或其抗原结合片段以及该抗体或该抗原结合片段用于预防或治疗癌症的用途。本发明的特征在于抗DR5抗体或其抗原结合片段在对DR5的亲和性、稳定性和杀伤癌细胞的作用方面有所改善。 |
| format | Patent |
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本发明涉及与死亡受体5(DR5)特异性结合并具有杀伤癌细胞功能的抗体。更具体地，提供了抗DR5抗体或其抗原结合片段以及该抗体或该抗原结合片段用于预防或治疗癌症的用途。本发明的特征在于抗DR5抗体或其抗原结合片段在对DR5的亲和性、稳定性和杀伤癌细胞的作用方面有所改善。</description><language>chi ; eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191231&DB=EPODOC&CC=CN&NR=110637032A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,782,887,25573,76557</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191231&DB=EPODOC&CC=CN&NR=110637032A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KIM DONGHYEON</creatorcontrib><creatorcontrib>SONG DONGSUP</creatorcontrib><creatorcontrib>LEE DONGSOP</creatorcontrib><creatorcontrib>HAN KYUNGMI</creatorcontrib><creatorcontrib>KIM YOOJIN</creatorcontrib><creatorcontrib>WOO SOYON</creatorcontrib><creatorcontrib>JUNG EUNEE</creatorcontrib><creatorcontrib>LEE HAN YOUNG</creatorcontrib><creatorcontrib>DOH HYOUNMIE</creatorcontrib><creatorcontrib>SHIN KUM-JOO</creatorcontrib><title>ANTI-DR5 ANTIBODY AND USE THEREOF</title><description>The present invention relates to an antibody that specifically binds to death receptor 5 (DR5) and has a function of killing cancer cells. Specifically, provided are an anti-DR5 antibody or antigen-binding fragment thereof, and a use of the antibody or antigen-binding fragment for preventing or treating cancer. The present invention is characterized in that the anti-DR5 antibody or antigen-bindingfragment thereof is improved in terms of affinity to DR5, stability, and an effect of killing cancer cells.
本发明涉及与死亡受体5(DR5)特异性结合并具有杀伤癌细胞功能的抗体。更具体地，提供了抗DR5抗体或其抗原结合片段以及该抗体或该抗原结合片段用于预防或治疗癌症的用途。本发明的特征在于抗DR5抗体或其抗原结合片段在对DR5的亲和性、稳定性和杀伤癌细胞的作用方面有所改善。</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFB09Avx1HUJMlUAMZz8XSKBDBeF0GBXhRAP1yBXfzceBta0xJziVF4ozc2g6OYa4uyhm1qQH59aXJCYnJqXWhLv7GdoaGBmbG5gbORoTIwaAPAbIcE</recordid><startdate>20191231</startdate><enddate>20191231</enddate><creator>KIM DONGHYEON</creator><creator>SONG DONGSUP</creator><creator>LEE DONGSOP</creator><creator>HAN KYUNGMI</creator><creator>KIM YOOJIN</creator><creator>WOO SOYON</creator><creator>JUNG EUNEE</creator><creator>LEE HAN YOUNG</creator><creator>DOH HYOUNMIE</creator><creator>SHIN KUM-JOO</creator><scope>EVB</scope></search><sort><creationdate>20191231</creationdate><title>ANTI-DR5 ANTIBODY AND USE THEREOF</title><author>KIM DONGHYEON ; SONG DONGSUP ; LEE DONGSOP ; HAN KYUNGMI ; KIM YOOJIN ; WOO SOYON ; JUNG EUNEE ; LEE HAN YOUNG ; DOH HYOUNMIE ; SHIN KUM-JOO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN110637032A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2019</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>KIM DONGHYEON</creatorcontrib><creatorcontrib>SONG DONGSUP</creatorcontrib><creatorcontrib>LEE DONGSOP</creatorcontrib><creatorcontrib>HAN KYUNGMI</creatorcontrib><creatorcontrib>KIM YOOJIN</creatorcontrib><creatorcontrib>WOO SOYON</creatorcontrib><creatorcontrib>JUNG EUNEE</creatorcontrib><creatorcontrib>LEE HAN YOUNG</creatorcontrib><creatorcontrib>DOH HYOUNMIE</creatorcontrib><creatorcontrib>SHIN KUM-JOO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KIM DONGHYEON</au><au>SONG DONGSUP</au><au>LEE DONGSOP</au><au>HAN KYUNGMI</au><au>KIM YOOJIN</au><au>WOO SOYON</au><au>JUNG EUNEE</au><au>LEE HAN YOUNG</au><au>DOH HYOUNMIE</au><au>SHIN KUM-JOO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ANTI-DR5 ANTIBODY AND USE THEREOF</title><date>2019-12-31</date><risdate>2019</risdate><abstract>The present invention relates to an antibody that specifically binds to death receptor 5 (DR5) and has a function of killing cancer cells. Specifically, provided are an anti-DR5 antibody or antigen-binding fragment thereof, and a use of the antibody or antigen-binding fragment for preventing or treating cancer. The present invention is characterized in that the anti-DR5 antibody or antigen-bindingfragment thereof is improved in terms of affinity to DR5, stability, and an effect of killing cancer cells.
本发明涉及与死亡受体5(DR5)特异性结合并具有杀伤癌细胞功能的抗体。更具体地，提供了抗DR5抗体或其抗原结合片段以及该抗体或该抗原结合片段用于预防或治疗癌症的用途。本发明的特征在于抗DR5抗体或其抗原结合片段在对DR5的亲和性、稳定性和杀伤癌细胞的作用方面有所改善。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | ANTI-DR5 ANTIBODY AND USE THEREOF |
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