Synthesis method of (E)-beta-monofluoroalkyl-beta,gamma-unsaturated amide

The invention relates to a synthesis method of a (E)-beta-monofluoroalkyl-beta,gamma-unsaturated amide. According to the synthesis method, a reaction of a terminal alkyne, 2-chloroacetamidoquinoline and a dialkyl 2-fluoromalonate are carried out through copper catalysis to synthesize the novel (E)-beta-monofluoroalkyl-beta,gamma-unsaturated amide compound by one step. A structural formula of the (E)-beta-monofluoroalkyl-beta,gamma-unsaturated amide is as shown in the specification. The method has simple reaction steps, cheap and easily-available raw materials, and a wide substrate range, and is suitable for industrial production. The prepared (E)-beta-monofluoroalkyl-beta,gamma-unsaturated amide compound can be used in the fields of medicine, pesticides and materials. 本发明涉及一种(E)-β-单氟烷基-β,γ-不饱和酰胺的合成方法，通过铜催化末端炔烃、2-氯乙酰胺基喹啉与2-氟丙二酸二烷基酯反应，一步合成新型(E)-β-单氟烷基-β,γ-不饱和酰胺化合物；所述(E)-β-单氟烷基-β,γ-不饱和酰胺的结构式如下：本发明方法反应步骤简单、原料廉价易得、底物范围宽泛，适用于工业生产，制得的(E)-β-单氟烷基-β,γ-不饱和酰胺化合物可应用于医药、农药及材料领域。