Metformin hydrochloride controlled release tablet and preparation method thereof
The invention relates to the field of pharmaceutical preparations, and particularly provides a metformin hydrochloride controlled release tablet and a preparation method thereof, and the metformin hydrochloride controlled release tablet comprises a double-layer tablet core (a drug layer and a boosti...
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| creator | KONG CHENXI LI CHENGWEN LIU WEI BIAN JIANGANG MA HAO ZHANG HUAWEI LIU JING |
| description | The invention relates to the field of pharmaceutical preparations, and particularly provides a metformin hydrochloride controlled release tablet and a preparation method thereof, and the metformin hydrochloride controlled release tablet comprises a double-layer tablet core (a drug layer and a boosting layer), an insoluble semipermeable membrane, drug release pores and a film coating. The metforminhydrochloride in the controlled-release tablet can be stably released at a constant speed, so that the problem of hysteresis of early-stage release of the drug is relieved, the problem of sudden release or no release of the drug in the middle and later stages is avoided, and the problem of drug residue in the last stage of drug release is solved. Through the invention, a drug release curve of a metformin hydrochloride controlled release preparation is more controllable and stable, the absorption and utilization degree of the drug is improved, and the clinical treatment effect is further guaranteed. Moreover, the prep |
| format | Patent |
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The metforminhydrochloride in the controlled-release tablet can be stably released at a constant speed, so that the problem of hysteresis of early-stage release of the drug is relieved, the problem of sudden release or no release of the drug in the middle and later stages is avoided, and the problem of drug residue in the last stage of drug release is solved. Through the invention, a drug release curve of a metformin hydrochloride controlled release preparation is more controllable and stable, the absorption and utilization degree of the drug is improved, and the clinical treatment effect is further guaranteed. Moreover, the prep</description><language>chi ; eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191231&DB=EPODOC&CC=CN&NR=110623933A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191231&DB=EPODOC&CC=CN&NR=110623933A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KONG CHENXI</creatorcontrib><creatorcontrib>LI CHENGWEN</creatorcontrib><creatorcontrib>LIU WEI</creatorcontrib><creatorcontrib>BIAN JIANGANG</creatorcontrib><creatorcontrib>MA HAO</creatorcontrib><creatorcontrib>ZHANG HUAWEI</creatorcontrib><creatorcontrib>LIU JING</creatorcontrib><title>Metformin hydrochloride controlled release tablet and preparation method thereof</title><description>The invention relates to the field of pharmaceutical preparations, and particularly provides a metformin hydrochloride controlled release tablet and a preparation method thereof, and the metformin hydrochloride controlled release tablet comprises a double-layer tablet core (a drug layer and a boosting layer), an insoluble semipermeable membrane, drug release pores and a film coating. The metforminhydrochloride in the controlled-release tablet can be stably released at a constant speed, so that the problem of hysteresis of early-stage release of the drug is relieved, the problem of sudden release or no release of the drug in the middle and later stages is avoided, and the problem of drug residue in the last stage of drug release is solved. Through the invention, a drug release curve of a metformin hydrochloride controlled release preparation is more controllable and stable, the absorption and utilization degree of the drug is improved, and the clinical treatment effect is further guaranteed. 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The metforminhydrochloride in the controlled-release tablet can be stably released at a constant speed, so that the problem of hysteresis of early-stage release of the drug is relieved, the problem of sudden release or no release of the drug in the middle and later stages is avoided, and the problem of drug residue in the last stage of drug release is solved. Through the invention, a drug release curve of a metformin hydrochloride controlled release preparation is more controllable and stable, the absorption and utilization degree of the drug is improved, and the clinical treatment effect is further guaranteed. Moreover, the prep</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Metformin hydrochloride controlled release tablet and preparation method thereof |
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