Process of removing multimer from human albumin
The invention provides a process of removing multimer from human albumin. The process comprises the following steps of S1, component separation; S2, human albumin purification procedure; S3, pasteurization process; S4, chromatography procedure; S5, secondary pasteurization procedures; and S6, steril...
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| creator | ZHANG BAOXIAN QING ZHOU TENG SHICHAO ZHANG HAIMENG ZHANG JIANCUI LI CHANGMING LIU YUJIANG XIAO LIANFENG |
| description | The invention provides a process of removing multimer from human albumin. The process comprises the following steps of S1, component separation; S2, human albumin purification procedure; S3, pasteurization process; S4, chromatography procedure; S5, secondary pasteurization procedures; and S6, sterile filling procedure. According to the human albumin preparation process provided by the invention, the process steps, including an ion exchange chromatography process and secondary pasteurization are added after a pasteurization process, and human albumin is prepared by replacing a traditional pasteurization method with a double pasteurization method, so that the quality of a product is improved, and the content of the multimer in the product is effectively lowered; and by effectively removing the contents of the multimer and impure proteins in the product, the quality of the human albumin is improved, occurrence of adverse reactions in the use process of the product is lowered, the market competitiveness of the hu |
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The process comprises the following steps of S1, component separation; S2, human albumin purification procedure; S3, pasteurization process; S4, chromatography procedure; S5, secondary pasteurization procedures; and S6, sterile filling procedure. According to the human albumin preparation process provided by the invention, the process steps, including an ion exchange chromatography process and secondary pasteurization are added after a pasteurization process, and human albumin is prepared by replacing a traditional pasteurization method with a double pasteurization method, so that the quality of a product is improved, and the content of the multimer in the product is effectively lowered; and by effectively removing the contents of the multimer and impure proteins in the product, the quality of the human albumin is improved, occurrence of adverse reactions in the use process of the product is lowered, the market competitiveness of the hu</description><language>chi ; eng</language><subject>CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191220&DB=EPODOC&CC=CN&NR=110590935A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191220&DB=EPODOC&CC=CN&NR=110590935A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZHANG BAOXIAN</creatorcontrib><creatorcontrib>QING ZHOU</creatorcontrib><creatorcontrib>TENG SHICHAO</creatorcontrib><creatorcontrib>ZHANG HAIMENG</creatorcontrib><creatorcontrib>ZHANG JIANCUI</creatorcontrib><creatorcontrib>LI CHANGMING</creatorcontrib><creatorcontrib>LIU YUJIANG</creatorcontrib><creatorcontrib>XIAO LIANFENG</creatorcontrib><title>Process of removing multimer from human albumin</title><description>The invention provides a process of removing multimer from human albumin. 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The process comprises the following steps of S1, component separation; S2, human albumin purification procedure; S3, pasteurization process; S4, chromatography procedure; S5, secondary pasteurization procedures; and S6, sterile filling procedure. According to the human albumin preparation process provided by the invention, the process steps, including an ion exchange chromatography process and secondary pasteurization are added after a pasteurization process, and human albumin is prepared by replacing a traditional pasteurization method with a double pasteurization method, so that the quality of a product is improved, and the content of the multimer in the product is effectively lowered; and by effectively removing the contents of the multimer and impure proteins in the product, the quality of the human albumin is improved, occurrence of adverse reactions in the use process of the product is lowered, the market competitiveness of the hu</abstract><oa>free_for_read</oa></addata></record> |
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| title | Process of removing multimer from human albumin |
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