RGDF-modified heptacyclic aldehyde, synthesis, antithrombotic activity and application thereof
The invention discloses Arg-Gly-Asp-Phe modified heptacyclic aldehyde shown as the following formula in the specification, namely (2'S, 5'S)-tetrahydropyrazine [1', 2': 1, 6]bis{(1R)-[1-ethyl-Arg-Gly-Asp-Phe]-2, 3, 4, 9-tetrahydro-1H-pyridine[3, 4-b]diindyl}-1', 4'-dike...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | SHI LINYI FENG QIQI ZHAO MING PENG SHIQI GUI LIN |
| description | The invention discloses Arg-Gly-Asp-Phe modified heptacyclic aldehyde shown as the following formula in the specification, namely (2'S, 5'S)-tetrahydropyrazine [1', 2': 1, 6]bis{(1R)-[1-ethyl-Arg-Gly-Asp-Phe]-2, 3, 4, 9-tetrahydro-1H-pyridine[3, 4-b]diindyl}-1', 4'-diketone, a preparation method thereof, anti-venous thrombosis activity thereof and anti-venous thrombosis dose dependence. Therefore,the invention discloses application of the Arg-Gly-Asp-Phe modified heptacyclic aldehyde in preparation of anti-venous thrombosis drugs.
本发明公开了下式的Arg-Gly-Asp-Phe修饰的七环醛,即(2'S,5'S)-四氢吡嗪[1',2':1,6]并双{(1R)-[1-乙基-Arg-Gly-Asp-Phe]-2,3,4,9-四氢-1H-吡啶[3,4-b]并吲哚}-1',4'-二酮,公开了它的制备方法,公开了它的抗静脉血栓活性，抗静脉血栓剂量依赖关系，因而本发明公开了它在制备抗静脉血栓药物中的应用。。 |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN110577583A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN110577583A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN110577583A3</originalsourceid><addsrcrecordid>eNqNy7EKwjAUheEuDqK-Q9xbsJTSrlKtTg7ibLkmN-RCmoTmIuTtjeADOB34-c66eN4vp7GavSJNqITBwCCTtCQFWIUmKSxFTI4NRoqlAMfEZvHzy_PXSKY3ccpdCQgh_4DJO5H9gl5vi5UGG3H3202xH8-P4Vph8BPGABId8jTc6vrQdl3bN8fmH_MBTHs88w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>RGDF-modified heptacyclic aldehyde, synthesis, antithrombotic activity and application thereof</title><source>esp@cenet</source><creator>SHI LINYI ; FENG QIQI ; ZHAO MING ; PENG SHIQI ; GUI LIN</creator><creatorcontrib>SHI LINYI ; FENG QIQI ; ZHAO MING ; PENG SHIQI ; GUI LIN</creatorcontrib><description>The invention discloses Arg-Gly-Asp-Phe modified heptacyclic aldehyde shown as the following formula in the specification, namely (2'S, 5'S)-tetrahydropyrazine [1', 2': 1, 6]bis{(1R)-[1-ethyl-Arg-Gly-Asp-Phe]-2, 3, 4, 9-tetrahydro-1H-pyridine[3, 4-b]diindyl}-1', 4'-diketone, a preparation method thereof, anti-venous thrombosis activity thereof and anti-venous thrombosis dose dependence. Therefore,the invention discloses application of the Arg-Gly-Asp-Phe modified heptacyclic aldehyde in preparation of anti-venous thrombosis drugs.
本发明公开了下式的Arg-Gly-Asp-Phe修饰的七环醛,即(2'S,5'S)-四氢吡嗪[1',2':1,6]并双{(1R)-[1-乙基-Arg-Gly-Asp-Phe]-2,3,4,9-四氢-1H-吡啶[3,4-b]并吲哚}-1',4'-二酮,公开了它的制备方法,公开了它的抗静脉血栓活性，抗静脉血栓剂量依赖关系，因而本发明公开了它在制备抗静脉血栓药物中的应用。。</description><language>chi ; eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191217&DB=EPODOC&CC=CN&NR=110577583A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191217&DB=EPODOC&CC=CN&NR=110577583A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SHI LINYI</creatorcontrib><creatorcontrib>FENG QIQI</creatorcontrib><creatorcontrib>ZHAO MING</creatorcontrib><creatorcontrib>PENG SHIQI</creatorcontrib><creatorcontrib>GUI LIN</creatorcontrib><title>RGDF-modified heptacyclic aldehyde, synthesis, antithrombotic activity and application thereof</title><description>The invention discloses Arg-Gly-Asp-Phe modified heptacyclic aldehyde shown as the following formula in the specification, namely (2'S, 5'S)-tetrahydropyrazine [1', 2': 1, 6]bis{(1R)-[1-ethyl-Arg-Gly-Asp-Phe]-2, 3, 4, 9-tetrahydro-1H-pyridine[3, 4-b]diindyl}-1', 4'-diketone, a preparation method thereof, anti-venous thrombosis activity thereof and anti-venous thrombosis dose dependence. Therefore,the invention discloses application of the Arg-Gly-Asp-Phe modified heptacyclic aldehyde in preparation of anti-venous thrombosis drugs.
本发明公开了下式的Arg-Gly-Asp-Phe修饰的七环醛,即(2'S,5'S)-四氢吡嗪[1',2':1,6]并双{(1R)-[1-乙基-Arg-Gly-Asp-Phe]-2,3,4,9-四氢-1H-吡啶[3,4-b]并吲哚}-1',4'-二酮,公开了它的制备方法,公开了它的抗静脉血栓活性，抗静脉血栓剂量依赖关系，因而本发明公开了它在制备抗静脉血栓药物中的应用。。</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNy7EKwjAUheEuDqK-Q9xbsJTSrlKtTg7ibLkmN-RCmoTmIuTtjeADOB34-c66eN4vp7GavSJNqITBwCCTtCQFWIUmKSxFTI4NRoqlAMfEZvHzy_PXSKY3ccpdCQgh_4DJO5H9gl5vi5UGG3H3202xH8-P4Vph8BPGABId8jTc6vrQdl3bN8fmH_MBTHs88w</recordid><startdate>20191217</startdate><enddate>20191217</enddate><creator>SHI LINYI</creator><creator>FENG QIQI</creator><creator>ZHAO MING</creator><creator>PENG SHIQI</creator><creator>GUI LIN</creator><scope>EVB</scope></search><sort><creationdate>20191217</creationdate><title>RGDF-modified heptacyclic aldehyde, synthesis, antithrombotic activity and application thereof</title><author>SHI LINYI ; FENG QIQI ; ZHAO MING ; PENG SHIQI ; GUI LIN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN110577583A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2019</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SHI LINYI</creatorcontrib><creatorcontrib>FENG QIQI</creatorcontrib><creatorcontrib>ZHAO MING</creatorcontrib><creatorcontrib>PENG SHIQI</creatorcontrib><creatorcontrib>GUI LIN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SHI LINYI</au><au>FENG QIQI</au><au>ZHAO MING</au><au>PENG SHIQI</au><au>GUI LIN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>RGDF-modified heptacyclic aldehyde, synthesis, antithrombotic activity and application thereof</title><date>2019-12-17</date><risdate>2019</risdate><abstract>The invention discloses Arg-Gly-Asp-Phe modified heptacyclic aldehyde shown as the following formula in the specification, namely (2'S, 5'S)-tetrahydropyrazine [1', 2': 1, 6]bis{(1R)-[1-ethyl-Arg-Gly-Asp-Phe]-2, 3, 4, 9-tetrahydro-1H-pyridine[3, 4-b]diindyl}-1', 4'-diketone, a preparation method thereof, anti-venous thrombosis activity thereof and anti-venous thrombosis dose dependence. Therefore,the invention discloses application of the Arg-Gly-Asp-Phe modified heptacyclic aldehyde in preparation of anti-venous thrombosis drugs.
本发明公开了下式的Arg-Gly-Asp-Phe修饰的七环醛,即(2'S,5'S)-四氢吡嗪[1',2':1,6]并双{(1R)-[1-乙基-Arg-Gly-Asp-Phe]-2,3,4,9-四氢-1H-吡啶[3,4-b]并吲哚}-1',4'-二酮,公开了它的制备方法,公开了它的抗静脉血栓活性，抗静脉血栓剂量依赖关系，因而本发明公开了它在制备抗静脉血栓药物中的应用。。</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_CN110577583A |
| source | esp@cenet |
| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | RGDF-modified heptacyclic aldehyde, synthesis, antithrombotic activity and application thereof |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T21%3A36%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=SHI%20LINYI&rft.date=2019-12-17&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN110577583A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |