Piperazine adenosine monophosphate activated protein kinase (AMPK) agonist and medical application thereof
The invention discloses a piperazine compound with AMPK agonist activity, and a preparation method and medical application of the piperazine compound. The piperazine compound is a compound shown as aformula (I) (please see the specifications for the formula), and a pharmaceutically acceptable salt o...
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| creator | ZHAO XING DAI LIANG YAN DINGFEI LI MINGLEI LIU JUN YAO ZHIYING CHENG YALONG HAN LISHUAI FENG ZHIQI SUN HONGBIN ZHANG XIANGYING ZHAO WENFENG WANG PENGFEI CHEN HUI ZHANG JIA LIU SHENGJIE WEN XIAO'AN WU WENZHEN SUN GENG YU SHENGQI |
| description | The invention discloses a piperazine compound with AMPK agonist activity, and a preparation method and medical application of the piperazine compound. The piperazine compound is a compound shown as aformula (I) (please see the specifications for the formula), and a pharmaceutically acceptable salt or ester or a prodrug or N-oxide or solvate thereof. The compound can be used for preparing drugs for preventing or treating AMPK-mediated diseases.
本发明公开了一种具有AMPK激动活性的哌嗪类化合物及其制备方法和医药用途，其为结构式如式(I)所示的化合物、其药学上可接受的盐或酯或前药或N-氧化物或溶剂化物。本发明的化合物可用于制备预防或治疗AMPK介导的疾病的药物。 |
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本发明公开了一种具有AMPK激动活性的哌嗪类化合物及其制备方法和医药用途，其为结构式如式(I)所示的化合物、其药学上可接受的盐或酯或前药或N-氧化物或溶剂化物。本发明的化合物可用于制备预防或治疗AMPK介导的疾病的药物。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyjEKwkAQheE0FqLeYey0EIwBtQ1BEURJYR-G7MSMbmaG7GLh6Y3gAazex-MfJ4-SjXp8sxCgI9HwVaei1mqwFuPw15FfAxxYr5FY4MmCgWCRX8rzEvCuwiECioOOHNfoAc38gMgqEFvqSZtpMmrQB5r9dpLMj4dbcVqRaUXBsCahWBXXNF1nu8022-fZP80Ht6dBJA</recordid><startdate>20191025</startdate><enddate>20191025</enddate><creator>ZHAO XING</creator><creator>DAI LIANG</creator><creator>YAN DINGFEI</creator><creator>LI MINGLEI</creator><creator>LIU JUN</creator><creator>YAO ZHIYING</creator><creator>CHENG YALONG</creator><creator>HAN LISHUAI</creator><creator>FENG ZHIQI</creator><creator>SUN HONGBIN</creator><creator>ZHANG XIANGYING</creator><creator>ZHAO WENFENG</creator><creator>WANG PENGFEI</creator><creator>CHEN HUI</creator><creator>ZHANG JIA</creator><creator>LIU SHENGJIE</creator><creator>WEN XIAO'AN</creator><creator>WU WENZHEN</creator><creator>SUN GENG</creator><creator>YU SHENGQI</creator><scope>EVB</scope></search><sort><creationdate>20191025</creationdate><title>Piperazine adenosine monophosphate activated protein kinase (AMPK) agonist and medical application thereof</title><author>ZHAO XING ; DAI LIANG ; YAN DINGFEI ; LI MINGLEI ; LIU JUN ; YAO ZHIYING ; CHENG YALONG ; HAN LISHUAI ; FENG ZHIQI ; SUN HONGBIN ; ZHANG XIANGYING ; ZHAO WENFENG ; WANG PENGFEI ; CHEN HUI ; ZHANG JIA ; LIU SHENGJIE ; WEN XIAO'AN ; WU WENZHEN ; SUN GENG ; YU SHENGQI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN110372638A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2019</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ZHAO XING</creatorcontrib><creatorcontrib>DAI LIANG</creatorcontrib><creatorcontrib>YAN DINGFEI</creatorcontrib><creatorcontrib>LI MINGLEI</creatorcontrib><creatorcontrib>LIU JUN</creatorcontrib><creatorcontrib>YAO ZHIYING</creatorcontrib><creatorcontrib>CHENG YALONG</creatorcontrib><creatorcontrib>HAN LISHUAI</creatorcontrib><creatorcontrib>FENG ZHIQI</creatorcontrib><creatorcontrib>SUN HONGBIN</creatorcontrib><creatorcontrib>ZHANG XIANGYING</creatorcontrib><creatorcontrib>ZHAO WENFENG</creatorcontrib><creatorcontrib>WANG PENGFEI</creatorcontrib><creatorcontrib>CHEN HUI</creatorcontrib><creatorcontrib>ZHANG JIA</creatorcontrib><creatorcontrib>LIU SHENGJIE</creatorcontrib><creatorcontrib>WEN XIAO'AN</creatorcontrib><creatorcontrib>WU WENZHEN</creatorcontrib><creatorcontrib>SUN GENG</creatorcontrib><creatorcontrib>YU SHENGQI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZHAO XING</au><au>DAI LIANG</au><au>YAN DINGFEI</au><au>LI MINGLEI</au><au>LIU JUN</au><au>YAO ZHIYING</au><au>CHENG YALONG</au><au>HAN LISHUAI</au><au>FENG ZHIQI</au><au>SUN HONGBIN</au><au>ZHANG XIANGYING</au><au>ZHAO WENFENG</au><au>WANG PENGFEI</au><au>CHEN HUI</au><au>ZHANG JIA</au><au>LIU SHENGJIE</au><au>WEN XIAO'AN</au><au>WU WENZHEN</au><au>SUN GENG</au><au>YU SHENGQI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Piperazine adenosine monophosphate activated protein kinase (AMPK) agonist and medical application thereof</title><date>2019-10-25</date><risdate>2019</risdate><abstract>The invention discloses a piperazine compound with AMPK agonist activity, and a preparation method and medical application of the piperazine compound. The piperazine compound is a compound shown as aformula (I) (please see the specifications for the formula), and a pharmaceutically acceptable salt or ester or a prodrug or N-oxide or solvate thereof. The compound can be used for preparing drugs for preventing or treating AMPK-mediated diseases.
本发明公开了一种具有AMPK激动活性的哌嗪类化合物及其制备方法和医药用途，其为结构式如式(I)所示的化合物、其药学上可接受的盐或酯或前药或N-氧化物或溶剂化物。本发明的化合物可用于制备预防或治疗AMPK介导的疾病的药物。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Piperazine adenosine monophosphate activated protein kinase (AMPK) agonist and medical application thereof |
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