Serpinc1 iRNA compositions and methods of use thereof

The invention relates to iRNA, e.g., double- stranded ribonucleic acid (dsRNA), compositions targeting the Serpinc1 gene, and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of Serpinc1 and methods of treating subjects having a bleeding disorder, such as a hemophilia. 本发明...

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Hauptverfasser:	BETTENCOURT BRIAN, MAIER MARTIN, IVANKA TOUDJARSKA, FOSTER DONALD, MILSTEIN STUART, ALFICA SEHGAL, KUCHIMANCHI SATYANARAYANA, AKIN AKINC, RADZHIV KALLANTKHOTTATKHIL G, MANOKHARAN MUTKHIAKH, CHARISSE KLAUS
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to iRNA, e.g., double- stranded ribonucleic acid (dsRNA), compositions targeting the Serpinc1 gene, and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of Serpinc1 and methods of treating subjects having a bleeding disorder, such as a hemophilia. 本发明涉及靶向Serpinc1基因的iRNA例如双链核糖核酸(dsRNA)组合物，和使用这类iRNA例如dsRNA组合物来抑制Serpinc1表达的方法以及治疗患有出血性障碍例如血友病的受试者的方法。