Preparation method of N-fluorenylmethoxycarbonyl-S-(4-methoxytribenzyl)-L-homocysteine
The invention relates to a preparation method of N-fluorenylmethoxycarbonyl-S-(4-methoxytribenzyl)-L-homocysteine, and solves the technical problem that there is no effective synthesis method in the prior art. The preparation method comprises following steps: (1) dissolving L-methionine into a solve...
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| creator | GU MENGJIE XU HONGYAN FU DENGLIANG DIAO XUNDONG |
| description | The invention relates to a preparation method of N-fluorenylmethoxycarbonyl-S-(4-methoxytribenzyl)-L-homocysteine, and solves the technical problem that there is no effective synthesis method in the prior art. The preparation method comprises following steps: (1) dissolving L-methionine into a solvent, and under the action of a strong reducing agent, removing one methyl group to prepare a crude product of L-homocysteine; (2) dissolving the crude product of L-homocysteine and 4-methoxytriphenyl chloromethane into a solvent, slowly adding a strong acid, TLC monitoring the reactions for 12 to 24 hours, carrying out suction filtration, adjusting the pH to 7 by an alkaline solution, carrying out suction filtration, and washing the obtained solid by a solvent to obtain S-(4-methoxytribenzyl)-L-homocysteine; and (3) dissolving S-(4-methoxytribenzyl)-L-homocysteine into a solvent, adding a fluorenylmethoxycarbonyl protective group onto S-(4-methoxytribenzyl)-L-homocysteine, TLC monitoring the reactions for 6 to 10 ho |
| format | Patent |
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The preparation method comprises following steps: (1) dissolving L-methionine into a solvent, and under the action of a strong reducing agent, removing one methyl group to prepare a crude product of L-homocysteine; (2) dissolving the crude product of L-homocysteine and 4-methoxytriphenyl chloromethane into a solvent, slowly adding a strong acid, TLC monitoring the reactions for 12 to 24 hours, carrying out suction filtration, adjusting the pH to 7 by an alkaline solution, carrying out suction filtration, and washing the obtained solid by a solvent to obtain S-(4-methoxytribenzyl)-L-homocysteine; and (3) dissolving S-(4-methoxytribenzyl)-L-homocysteine into a solvent, adding a fluorenylmethoxycarbonyl protective group onto S-(4-methoxytribenzyl)-L-homocysteine, TLC monitoring the reactions for 6 to 10 ho</description><language>chi ; eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190920&DB=EPODOC&CC=CN&NR=110256310A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25544,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190920&DB=EPODOC&CC=CN&NR=110256310A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GU MENGJIE</creatorcontrib><creatorcontrib>XU HONGYAN</creatorcontrib><creatorcontrib>FU DENGLIANG</creatorcontrib><creatorcontrib>DIAO XUNDONG</creatorcontrib><title>Preparation method of N-fluorenylmethoxycarbonyl-S-(4-methoxytribenzyl)-L-homocysteine</title><description>The invention relates to a preparation method of N-fluorenylmethoxycarbonyl-S-(4-methoxytribenzyl)-L-homocysteine, and solves the technical problem that there is no effective synthesis method in the prior art. The preparation method comprises following steps: (1) dissolving L-methionine into a solvent, and under the action of a strong reducing agent, removing one methyl group to prepare a crude product of L-homocysteine; (2) dissolving the crude product of L-homocysteine and 4-methoxytriphenyl chloromethane into a solvent, slowly adding a strong acid, TLC monitoring the reactions for 12 to 24 hours, carrying out suction filtration, adjusting the pH to 7 by an alkaline solution, carrying out suction filtration, and washing the obtained solid by a solvent to obtain S-(4-methoxytribenzyl)-L-homocysteine; and (3) dissolving S-(4-methoxytribenzyl)-L-homocysteine into a solvent, adding a fluorenylmethoxycarbonyl protective group onto S-(4-methoxytribenzyl)-L-homocysteine, TLC monitoring the reactions for 6 to 10 ho</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZAgLKEotSCxKLMnMz1PITS3JyE9RyE9T8NNNyynNL0rNq8wBC1ZUJicWJeUDubrBuhomulDBkqLMpNS8qsocTV0f3Yz83PzkyuKS1My8VB4G1rTEnOJUXijNzaDo5hri7KGbWpAfn1pckJicmpdaEu_sZ2hoYGRqZmxo4GhMjBoAeI46Lg</recordid><startdate>20190920</startdate><enddate>20190920</enddate><creator>GU MENGJIE</creator><creator>XU HONGYAN</creator><creator>FU DENGLIANG</creator><creator>DIAO XUNDONG</creator><scope>EVB</scope></search><sort><creationdate>20190920</creationdate><title>Preparation method of N-fluorenylmethoxycarbonyl-S-(4-methoxytribenzyl)-L-homocysteine</title><author>GU MENGJIE ; XU HONGYAN ; FU DENGLIANG ; DIAO XUNDONG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN110256310A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2019</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>GU MENGJIE</creatorcontrib><creatorcontrib>XU HONGYAN</creatorcontrib><creatorcontrib>FU DENGLIANG</creatorcontrib><creatorcontrib>DIAO XUNDONG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GU MENGJIE</au><au>XU HONGYAN</au><au>FU DENGLIANG</au><au>DIAO XUNDONG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Preparation method of N-fluorenylmethoxycarbonyl-S-(4-methoxytribenzyl)-L-homocysteine</title><date>2019-09-20</date><risdate>2019</risdate><abstract>The invention relates to a preparation method of N-fluorenylmethoxycarbonyl-S-(4-methoxytribenzyl)-L-homocysteine, and solves the technical problem that there is no effective synthesis method in the prior art. The preparation method comprises following steps: (1) dissolving L-methionine into a solvent, and under the action of a strong reducing agent, removing one methyl group to prepare a crude product of L-homocysteine; (2) dissolving the crude product of L-homocysteine and 4-methoxytriphenyl chloromethane into a solvent, slowly adding a strong acid, TLC monitoring the reactions for 12 to 24 hours, carrying out suction filtration, adjusting the pH to 7 by an alkaline solution, carrying out suction filtration, and washing the obtained solid by a solvent to obtain S-(4-methoxytribenzyl)-L-homocysteine; and (3) dissolving S-(4-methoxytribenzyl)-L-homocysteine into a solvent, adding a fluorenylmethoxycarbonyl protective group onto S-(4-methoxytribenzyl)-L-homocysteine, TLC monitoring the reactions for 6 to 10 ho</abstract><oa>free_for_read</oa></addata></record> |
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| title | Preparation method of N-fluorenylmethoxycarbonyl-S-(4-methoxytribenzyl)-L-homocysteine |
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