Corynebacterium glutamicum establishment method for increasing yield of L-lysine and improving stability of L-lysine
The invention relates to a corynebacterium glutamicum establishment method for increasing the yield of L-lysine and improving the stability of the L-lysine. According to the method, after a Tnp7a geneof corynebacterium glutamicum is inactivated, the corynebacterium glutamicum is established, and an...
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| creator | WANG SONGJIANG GUO CHUANZHUANG SUI SONGSEN WANG JIANBIN |
| description | The invention relates to a corynebacterium glutamicum establishment method for increasing the yield of L-lysine and improving the stability of the L-lysine. According to the method, after a Tnp7a geneof corynebacterium glutamicum is inactivated, the corynebacterium glutamicum is established, and an amino acid sequence of the Tnp7a gene is shown in SEQ ID NO:1. According to the corynebacterium glutamicum establishment method for increasing the yield of the L-lysine and improving the stability of the L-lysine, the endogenous gene Tnp7a of the established corynebacterium glutamicum is inactivated, the transposition effect, caused when an insertion sequence is activated due to an environment change, of the corynebacterium glutamicum in the preservation and fermentation process is lowered, thestrain degeneration progress, caused by mutation or frame shift generated by transposition or adjustment on expression of adjacent genes through promoters carried by a genome, of the genome is blocked, and the yield of the L- |
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According to the method, after a Tnp7a geneof corynebacterium glutamicum is inactivated, the corynebacterium glutamicum is established, and an amino acid sequence of the Tnp7a gene is shown in SEQ ID NO:1. 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According to the method, after a Tnp7a geneof corynebacterium glutamicum is inactivated, the corynebacterium glutamicum is established, and an amino acid sequence of the Tnp7a gene is shown in SEQ ID NO:1. According to the corynebacterium glutamicum establishment method for increasing the yield of the L-lysine and improving the stability of the L-lysine, the endogenous gene Tnp7a of the established corynebacterium glutamicum is inactivated, the transposition effect, caused when an insertion sequence is activated due to an environment change, of the corynebacterium glutamicum in the preservation and fermentation process is lowered, thestrain degeneration progress, caused by mutation or frame shift generated by transposition or adjustment on expression of adjacent genes through promoters carried by a genome, of the genome is blocked, and the yield of the L-</abstract><oa>free_for_read</oa></addata></record> |
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| language | chi ; eng |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | Corynebacterium glutamicum establishment method for increasing yield of L-lysine and improving stability of L-lysine |
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