USE OF CYCLO TYROSINE-VALINE AND ANALOG COMPOUNDS TO TREAT ASTHMA AND AIRWAY ALLERGY
The present invention provides a method to treat asthma and airway allergy by administering the dipeptide cyclo tyrosine-valine or a related cyclodipeptide compound to a subject in need thereof. Cyclotyrosine-valine or the related cyclodipeptide compound reduces Th2 cell activation, airway hyperresp...
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| creator | LAI HSINIH LIAU JIANING MARTEL JAN LIN CHUAN-SHENG HSIEH PEI-WEN LU CHIAN YOUNG JOHN D ANTIG LUIS DOMINICK B CHANG CHIH-JUNG CHIU CHEN-YAW WU TSUNG-RU OJCIUS DAVID MARCELO KO YUN-FEI CHEN YU-LI |
| description | The present invention provides a method to treat asthma and airway allergy by administering the dipeptide cyclo tyrosine-valine or a related cyclodipeptide compound to a subject in need thereof. Cyclotyrosine-valine or the related cyclodipeptide compound reduces Th2 cell activation, airway hyperresponsiveness, accumulation of immune cells in bronchoalveolar fluid, and allergen-specific antibody production in an animal or human subject. The compound can therefore be used to treat asthma and airway allergy.
本发明提供一种环状酪氨酸-缬氨酸及其类似物用于治疗气喘及呼吸道过敏的用途。环状酪氨酸-缬氨酸是一种二肽化合物，其可减少动物或人类个体的Th2细胞活化、呼吸道过度反应、支气管肺泡液中免疫细胞积聚、及抗原专一性抗体的生成，因此，其可用于治疗气喘及呼吸道过敏。 |
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本发明提供一种环状酪氨酸-缬氨酸及其类似物用于治疗气喘及呼吸道过敏的用途。环状酪氨酸-缬氨酸是一种二肽化合物，其可减少动物或人类个体的Th2细胞活化、呼吸道过度反应、支气管肺泡液中免疫细胞积聚、及抗原专一性抗体的生成，因此，其可用于治疗气喘及呼吸道过敏。</description><language>chi ; eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190625&DB=EPODOC&CC=CN&NR=109925315A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190625&DB=EPODOC&CC=CN&NR=109925315A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LAI HSINIH</creatorcontrib><creatorcontrib>LIAU JIANING</creatorcontrib><creatorcontrib>MARTEL JAN</creatorcontrib><creatorcontrib>LIN CHUAN-SHENG</creatorcontrib><creatorcontrib>HSIEH PEI-WEN</creatorcontrib><creatorcontrib>LU CHIAN</creatorcontrib><creatorcontrib>YOUNG JOHN D</creatorcontrib><creatorcontrib>ANTIG LUIS DOMINICK B</creatorcontrib><creatorcontrib>CHANG CHIH-JUNG</creatorcontrib><creatorcontrib>CHIU CHEN-YAW</creatorcontrib><creatorcontrib>WU TSUNG-RU</creatorcontrib><creatorcontrib>OJCIUS DAVID MARCELO</creatorcontrib><creatorcontrib>KO YUN-FEI</creatorcontrib><creatorcontrib>CHEN YU-LI</creatorcontrib><title>USE OF CYCLO TYROSINE-VALINE AND ANALOG COMPOUNDS TO TREAT ASTHMA AND AIRWAY ALLERGY</title><description>The present invention provides a method to treat asthma and airway allergy by administering the dipeptide cyclo tyrosine-valine or a related cyclodipeptide compound to a subject in need thereof. Cyclotyrosine-valine or the related cyclodipeptide compound reduces Th2 cell activation, airway hyperresponsiveness, accumulation of immune cells in bronchoalveolar fluid, and allergen-specific antibody production in an animal or human subject. The compound can therefore be used to treat asthma and airway allergy.
本发明提供一种环状酪氨酸-缬氨酸及其类似物用于治疗气喘及呼吸道过敏的用途。环状酪氨酸-缬氨酸是一种二肽化合物，其可减少动物或人类个体的Th2细胞活化、呼吸道过度反应、支气管肺泡液中免疫细胞积聚、及抗原专一性抗体的生成，因此，其可用于治疗气喘及呼吸道过敏。</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZAgJDXZV8HdTcI509vFXCIkM8g_29HPVDXP0AVIKjn4uQOzo4--u4OzvG-Af6ucSrBACVBfk6hii4Bgc4uHrCFHkGRTuGKng6OPjGuQeycPAmpaYU5zKC6W5GRTdXEOcPXRTC_LjU4sLEpNT81JL4p39DA0sLY1MjQ1NHY2JUQMAFaIv9A</recordid><startdate>20190625</startdate><enddate>20190625</enddate><creator>LAI HSINIH</creator><creator>LIAU JIANING</creator><creator>MARTEL JAN</creator><creator>LIN CHUAN-SHENG</creator><creator>HSIEH PEI-WEN</creator><creator>LU CHIAN</creator><creator>YOUNG JOHN D</creator><creator>ANTIG LUIS DOMINICK B</creator><creator>CHANG CHIH-JUNG</creator><creator>CHIU CHEN-YAW</creator><creator>WU TSUNG-RU</creator><creator>OJCIUS DAVID MARCELO</creator><creator>KO YUN-FEI</creator><creator>CHEN YU-LI</creator><scope>EVB</scope></search><sort><creationdate>20190625</creationdate><title>USE OF CYCLO TYROSINE-VALINE AND ANALOG COMPOUNDS TO TREAT ASTHMA AND AIRWAY ALLERGY</title><author>LAI HSINIH ; LIAU JIANING ; MARTEL JAN ; LIN CHUAN-SHENG ; HSIEH PEI-WEN ; LU CHIAN ; YOUNG JOHN D ; ANTIG LUIS DOMINICK B ; CHANG CHIH-JUNG ; CHIU CHEN-YAW ; WU TSUNG-RU ; OJCIUS DAVID MARCELO ; KO YUN-FEI ; CHEN YU-LI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN109925315A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2019</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>LAI HSINIH</creatorcontrib><creatorcontrib>LIAU JIANING</creatorcontrib><creatorcontrib>MARTEL JAN</creatorcontrib><creatorcontrib>LIN CHUAN-SHENG</creatorcontrib><creatorcontrib>HSIEH PEI-WEN</creatorcontrib><creatorcontrib>LU CHIAN</creatorcontrib><creatorcontrib>YOUNG JOHN D</creatorcontrib><creatorcontrib>ANTIG LUIS DOMINICK B</creatorcontrib><creatorcontrib>CHANG CHIH-JUNG</creatorcontrib><creatorcontrib>CHIU CHEN-YAW</creatorcontrib><creatorcontrib>WU TSUNG-RU</creatorcontrib><creatorcontrib>OJCIUS DAVID MARCELO</creatorcontrib><creatorcontrib>KO YUN-FEI</creatorcontrib><creatorcontrib>CHEN YU-LI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LAI HSINIH</au><au>LIAU JIANING</au><au>MARTEL JAN</au><au>LIN CHUAN-SHENG</au><au>HSIEH PEI-WEN</au><au>LU CHIAN</au><au>YOUNG JOHN D</au><au>ANTIG LUIS DOMINICK B</au><au>CHANG CHIH-JUNG</au><au>CHIU CHEN-YAW</au><au>WU TSUNG-RU</au><au>OJCIUS DAVID MARCELO</au><au>KO YUN-FEI</au><au>CHEN YU-LI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>USE OF CYCLO TYROSINE-VALINE AND ANALOG COMPOUNDS TO TREAT ASTHMA AND AIRWAY ALLERGY</title><date>2019-06-25</date><risdate>2019</risdate><abstract>The present invention provides a method to treat asthma and airway allergy by administering the dipeptide cyclo tyrosine-valine or a related cyclodipeptide compound to a subject in need thereof. Cyclotyrosine-valine or the related cyclodipeptide compound reduces Th2 cell activation, airway hyperresponsiveness, accumulation of immune cells in bronchoalveolar fluid, and allergen-specific antibody production in an animal or human subject. The compound can therefore be used to treat asthma and airway allergy.
本发明提供一种环状酪氨酸-缬氨酸及其类似物用于治疗气喘及呼吸道过敏的用途。环状酪氨酸-缬氨酸是一种二肽化合物，其可减少动物或人类个体的Th2细胞活化、呼吸道过度反应、支气管肺泡液中免疫细胞积聚、及抗原专一性抗体的生成，因此，其可用于治疗气喘及呼吸道过敏。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | USE OF CYCLO TYROSINE-VALINE AND ANALOG COMPOUNDS TO TREAT ASTHMA AND AIRWAY ALLERGY |
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