Preparation method of tetracyclic indoline compounds

The invention belongs to the field of organic synthesis, and specifically discloses a preparation method of tetracyclic indoline compounds. The tetracyclic indoline compounds are synthesized by the step of performing a tandem cyclization reaction on an amide derivative and an alkyne under the action of a palladium catalyst. The method specifically comprises the following steps: using metal palladium as the catalyst, and performing a reaction under combined action of a ligand, a base and an additive in an organic solvent at 40-150 DEG C to form one corresponding tetracyclic indoline compound. The method provided by the invention uses the easily-prepared amide and alkyne as raw materials to realize rapid construction of the complex tetracyclic indoline compounds by constructing two rings andthree chemical bonds in one step; and the method has mild reaction conditions, is simple and convenient to operate, and has the advantages that the reaction raw materials are easy to obtain, the functional group tolerance is