Method for synthesizing compound Paulownione C and Tomentodiplone O

The invention relates to a method for synthesizing natural products Tomentodiplacone O and Paulownione C. The method adopts 2, 4, 6-Trihydroxyacetophenone monohydrate compound, citral, clove aldehydeand vanillin as initial raw materials, general inorganic alkali as a catalyst, and methanol with low toxicity as a solvent; high-toxicity pyridine is avoided, and two natural products Tomentodiplone Oand Paulownione C are prepared through five steps. The method has the advantages of simple synthetic route, simple operation, green and high efficiency, thereby solving the problem of high toxicity and low yield of the prepared benzopyran compound, and the method has certain industrial economic value. 本发明涉及天然产物Tomentodiplacone O和Paulownione C的合成方法。本发明采用2，4，6-三羟基苯乙酮一水化合物、柠檬醛、丁香醛和香草醛为起始原料，使用一般的无机碱做催化剂，毒性较低的甲醇做溶剂，避免使用高毒性的吡啶，经过五步制备出两个天然产物Tomentodiplacone O和Paulownione C。本发明的合成路线简洁，操作简单，绿色高效的解决了制备苯并吡喃化合物高毒低产的问题，具有一定的工业经济价值。