Levofloxacin lactate dispersible tablet and preparation method thereof
The invention discloses a levofloxacin lactate dispersible tablet. The dispersible tablet comprises, by weight, 100 parts of levofloxacin lactate, 40-45 parts of microcrystalline cellulose, 20-27 parts of sodium carboxymethyl starch, 38-42 parts of starch, 1-2 parts of micro-powder silica gel, 2-3 p...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | LIU JIANGANG KE KECONG CHEN YAN LIN ZUXIE LIU QUANSHENG LIU CHUNYAN XING ZHENKAI |
| description | The invention discloses a levofloxacin lactate dispersible tablet. The dispersible tablet comprises, by weight, 100 parts of levofloxacin lactate, 40-45 parts of microcrystalline cellulose, 20-27 parts of sodium carboxymethyl starch, 38-42 parts of starch, 1-2 parts of micro-powder silica gel, 2-3 parts of magnesium stearate and 10-20 parts of ethanol water with the mass fraction of 60-70%, wherein the starch is hydroxypropyl starch; the micro-powder silica gel is silica gel modified by trimethyl chlorosilane. Part of auxiliary materials are optimized so that the usage quantity of the auxiliary materials can be greatly reduced, related substances, content, dissolution rate, dispersion uniformity and stability of the product are also improved, and therefore the aims of reducing the production cost and improving the product quality are achieved at the same time.
本发明公开了一种乳酸左氧氟沙星分散片，包括以下重量份的成分：乳酸左氧氟沙星100份、微晶纤维素40～45份、羧甲淀粉钠20～27份、淀粉38～42份、微粉硅胶1～2份、硬脂酸镁2～3份和质量分数60～70％的乙醇水10～20份；所述淀粉为羟丙基淀粉；所述微粉硅胶为经三甲基氯硅烷修饰的微粉硅胶。本发明主 |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN109730969A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN109730969A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN109730969A3</originalsourceid><addsrcrecordid>eNqNyjEKAjEQRuE0FqLeYTyAsLKgpJTFxUKs7Jcx-cMGYiYkg3h8LTyAzfuatzTjFS8JSd7sYqbETllBPraC2uIjgZS_VeLsqVQUrqxRMj2hs3jSGRUS1mYRODVsfq7Mdjzfh8sORSa0wg4ZOg23fWePfWcP9tT_83wAf940RQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Levofloxacin lactate dispersible tablet and preparation method thereof</title><source>esp@cenet</source><creator>LIU JIANGANG ; KE KECONG ; CHEN YAN ; LIN ZUXIE ; LIU QUANSHENG ; LIU CHUNYAN ; XING ZHENKAI</creator><creatorcontrib>LIU JIANGANG ; KE KECONG ; CHEN YAN ; LIN ZUXIE ; LIU QUANSHENG ; LIU CHUNYAN ; XING ZHENKAI</creatorcontrib><description>The invention discloses a levofloxacin lactate dispersible tablet. The dispersible tablet comprises, by weight, 100 parts of levofloxacin lactate, 40-45 parts of microcrystalline cellulose, 20-27 parts of sodium carboxymethyl starch, 38-42 parts of starch, 1-2 parts of micro-powder silica gel, 2-3 parts of magnesium stearate and 10-20 parts of ethanol water with the mass fraction of 60-70%, wherein the starch is hydroxypropyl starch; the micro-powder silica gel is silica gel modified by trimethyl chlorosilane. Part of auxiliary materials are optimized so that the usage quantity of the auxiliary materials can be greatly reduced, related substances, content, dissolution rate, dispersion uniformity and stability of the product are also improved, and therefore the aims of reducing the production cost and improving the product quality are achieved at the same time.
本发明公开了一种乳酸左氧氟沙星分散片，包括以下重量份的成分：乳酸左氧氟沙星100份、微晶纤维素40～45份、羧甲淀粉钠20～27份、淀粉38～42份、微粉硅胶1～2份、硬脂酸镁2～3份和质量分数60～70％的乙醇水10～20份；所述淀粉为羟丙基淀粉；所述微粉硅胶为经三甲基氯硅烷修饰的微粉硅胶。本发明主</description><language>chi ; eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190510&DB=EPODOC&CC=CN&NR=109730969A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190510&DB=EPODOC&CC=CN&NR=109730969A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LIU JIANGANG</creatorcontrib><creatorcontrib>KE KECONG</creatorcontrib><creatorcontrib>CHEN YAN</creatorcontrib><creatorcontrib>LIN ZUXIE</creatorcontrib><creatorcontrib>LIU QUANSHENG</creatorcontrib><creatorcontrib>LIU CHUNYAN</creatorcontrib><creatorcontrib>XING ZHENKAI</creatorcontrib><title>Levofloxacin lactate dispersible tablet and preparation method thereof</title><description>The invention discloses a levofloxacin lactate dispersible tablet. The dispersible tablet comprises, by weight, 100 parts of levofloxacin lactate, 40-45 parts of microcrystalline cellulose, 20-27 parts of sodium carboxymethyl starch, 38-42 parts of starch, 1-2 parts of micro-powder silica gel, 2-3 parts of magnesium stearate and 10-20 parts of ethanol water with the mass fraction of 60-70%, wherein the starch is hydroxypropyl starch; the micro-powder silica gel is silica gel modified by trimethyl chlorosilane. Part of auxiliary materials are optimized so that the usage quantity of the auxiliary materials can be greatly reduced, related substances, content, dissolution rate, dispersion uniformity and stability of the product are also improved, and therefore the aims of reducing the production cost and improving the product quality are achieved at the same time.
本发明公开了一种乳酸左氧氟沙星分散片，包括以下重量份的成分：乳酸左氧氟沙星100份、微晶纤维素40～45份、羧甲淀粉钠20～27份、淀粉38～42份、微粉硅胶1～2份、硬脂酸镁2～3份和质量分数60～70％的乙醇水10～20份；所述淀粉为羟丙基淀粉；所述微粉硅胶为经三甲基氯硅烷修饰的微粉硅胶。本发明主</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyjEKAjEQRuE0FqLeYTyAsLKgpJTFxUKs7Jcx-cMGYiYkg3h8LTyAzfuatzTjFS8JSd7sYqbETllBPraC2uIjgZS_VeLsqVQUrqxRMj2hs3jSGRUS1mYRODVsfq7Mdjzfh8sORSa0wg4ZOg23fWePfWcP9tT_83wAf940RQ</recordid><startdate>20190510</startdate><enddate>20190510</enddate><creator>LIU JIANGANG</creator><creator>KE KECONG</creator><creator>CHEN YAN</creator><creator>LIN ZUXIE</creator><creator>LIU QUANSHENG</creator><creator>LIU CHUNYAN</creator><creator>XING ZHENKAI</creator><scope>EVB</scope></search><sort><creationdate>20190510</creationdate><title>Levofloxacin lactate dispersible tablet and preparation method thereof</title><author>LIU JIANGANG ; KE KECONG ; CHEN YAN ; LIN ZUXIE ; LIU QUANSHENG ; LIU CHUNYAN ; XING ZHENKAI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN109730969A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2019</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>LIU JIANGANG</creatorcontrib><creatorcontrib>KE KECONG</creatorcontrib><creatorcontrib>CHEN YAN</creatorcontrib><creatorcontrib>LIN ZUXIE</creatorcontrib><creatorcontrib>LIU QUANSHENG</creatorcontrib><creatorcontrib>LIU CHUNYAN</creatorcontrib><creatorcontrib>XING ZHENKAI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LIU JIANGANG</au><au>KE KECONG</au><au>CHEN YAN</au><au>LIN ZUXIE</au><au>LIU QUANSHENG</au><au>LIU CHUNYAN</au><au>XING ZHENKAI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Levofloxacin lactate dispersible tablet and preparation method thereof</title><date>2019-05-10</date><risdate>2019</risdate><abstract>The invention discloses a levofloxacin lactate dispersible tablet. The dispersible tablet comprises, by weight, 100 parts of levofloxacin lactate, 40-45 parts of microcrystalline cellulose, 20-27 parts of sodium carboxymethyl starch, 38-42 parts of starch, 1-2 parts of micro-powder silica gel, 2-3 parts of magnesium stearate and 10-20 parts of ethanol water with the mass fraction of 60-70%, wherein the starch is hydroxypropyl starch; the micro-powder silica gel is silica gel modified by trimethyl chlorosilane. Part of auxiliary materials are optimized so that the usage quantity of the auxiliary materials can be greatly reduced, related substances, content, dissolution rate, dispersion uniformity and stability of the product are also improved, and therefore the aims of reducing the production cost and improving the product quality are achieved at the same time.
本发明公开了一种乳酸左氧氟沙星分散片，包括以下重量份的成分：乳酸左氧氟沙星100份、微晶纤维素40～45份、羧甲淀粉钠20～27份、淀粉38～42份、微粉硅胶1～2份、硬脂酸镁2～3份和质量分数60～70％的乙醇水10～20份；所述淀粉为羟丙基淀粉；所述微粉硅胶为经三甲基氯硅烷修饰的微粉硅胶。本发明主</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_CN109730969A |
| source | esp@cenet |
| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Levofloxacin lactate dispersible tablet and preparation method thereof |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T18%3A17%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=LIU%20JIANGANG&rft.date=2019-05-10&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN109730969A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |