COMPOSITION COMPRISING SELF-ASSEMBLING PEPTIDES FOR USE IN TREATMENT OF GINGIVITIS, PERIODONTITIS AND/OR PERI-IMPLANTITIS
The present invention provides a composition comprising specific self-assembling peptides, which are capable of self-assembly at a pH below 7.5 and at least physiologic ionic strength, e.g., PI 1-4. PI 1-8, PI 1-14, PI 1-13, PI 1-12, PI 1-28, PI 1-29, PI 1-2, PI 1-5, PI 1-17, PI 1-19, PI 1-20, PI 1-...
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| creator | MEYER NINA BROESELER FRANK PIELES UWE JUNG RONALD LYSEK DOMINIKUS AMADEUS HAEMMERLE CHRISTOPH MATHES STEPHANIE HUG MICHAEL KOCH FRANZISKA |
| description | The present invention provides a composition comprising specific self-assembling peptides, which are capable of self-assembly at a pH below 7.5 and at least physiologic ionic strength, e.g., PI 1-4. PI 1-8, PI 1-14, PI 1-13, PI 1-12, PI 1-28, PI 1-29, PI 1-2, PI 1-5, PI 1-17, PI 1-19, PI 1-20, PI 1-12, PI 1-16, PI 1-18, PI 1-26 or PI 1-31 for use in treating an oral disease selected from the groupconsisting of gingivitis, periodontitis and/or peri-implantitis in a subject. Said composition may be used, after suitable cleaning procedures, for filling pockets formed adjacent to teeth in said diseases, which enhances tissue regeneration. The composition may be suitable for controlled release of an active agent, e.g., an antimicrobial or antibiotic agent. The invention also provides a kit suitable for said treatment further comprising self-assembling peptides suitable for forming a second layer on top of the first composition.
本发明提供一种包含特定自组装肽的组合物，所述自组装肽能够在低于7.5的pH和至少生理离子强度下自组装，例如P11-4、P11-8、P11-14、P11-13、P11-12、P |
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本发明提供一种包含特定自组装肽的组合物，所述自组装肽能够在低于7.5的pH和至少生理离子强度下自组装，例如P11-4、P11-8、P11-14、P11-13、P11-12、P</description><language>chi ; eng</language><subject>CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES ; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR ; HUMAN NECESSITIES ; HYGIENE ; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES ; MEDICAL OR VETERINARY SCIENCE ; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190503&DB=EPODOC&CC=CN&NR=109715193A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190503&DB=EPODOC&CC=CN&NR=109715193A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MEYER NINA</creatorcontrib><creatorcontrib>BROESELER FRANK</creatorcontrib><creatorcontrib>PIELES UWE</creatorcontrib><creatorcontrib>JUNG RONALD</creatorcontrib><creatorcontrib>LYSEK DOMINIKUS AMADEUS</creatorcontrib><creatorcontrib>HAEMMERLE CHRISTOPH</creatorcontrib><creatorcontrib>MATHES STEPHANIE</creatorcontrib><creatorcontrib>HUG MICHAEL</creatorcontrib><creatorcontrib>KOCH FRANZISKA</creatorcontrib><title>COMPOSITION COMPRISING SELF-ASSEMBLING PEPTIDES FOR USE IN TREATMENT OF GINGIVITIS, PERIODONTITIS AND/OR PERI-IMPLANTITIS</title><description>The present invention provides a composition comprising specific self-assembling peptides, which are capable of self-assembly at a pH below 7.5 and at least physiologic ionic strength, e.g., PI 1-4. PI 1-8, PI 1-14, PI 1-13, PI 1-12, PI 1-28, PI 1-29, PI 1-2, PI 1-5, PI 1-17, PI 1-19, PI 1-20, PI 1-12, PI 1-16, PI 1-18, PI 1-26 or PI 1-31 for use in treating an oral disease selected from the groupconsisting of gingivitis, periodontitis and/or peri-implantitis in a subject. Said composition may be used, after suitable cleaning procedures, for filling pockets formed adjacent to teeth in said diseases, which enhances tissue regeneration. The composition may be suitable for controlled release of an active agent, e.g., an antimicrobial or antibiotic agent. The invention also provides a kit suitable for said treatment further comprising self-assembling peptides suitable for forming a second layer on top of the first composition.
本发明提供一种包含特定自组装肽的组合物，所述自组装肽能够在低于7.5的pH和至少生理离子强度下自组装，例如P11-4、P11-8、P11-14、P11-13、P11-12、P</description><subject>CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES</subject><subject>DISINFECTION, STERILISATION, OR DEODORISATION OF AIR</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjL0KwjAUhbs4iPoO192ipYh0jO1NvdD8kBtdS5E4iRbq4tuboA_gdH74zpln79ooa5g8GQ3JO2LSLTB2MhfMqI5dyhatpwYZpHFwZgTS4B0Kr1B7MBLaSNEl_vAmwo5MY7RPEYRutnGUypyU7cS3X2az23Cfwuqni2wt0denPIzPPkzjcA2P8OprXeyqQ7EvqlKU_zAfNIc66Q</recordid><startdate>20190503</startdate><enddate>20190503</enddate><creator>MEYER NINA</creator><creator>BROESELER FRANK</creator><creator>PIELES UWE</creator><creator>JUNG RONALD</creator><creator>LYSEK DOMINIKUS AMADEUS</creator><creator>HAEMMERLE CHRISTOPH</creator><creator>MATHES STEPHANIE</creator><creator>HUG MICHAEL</creator><creator>KOCH FRANZISKA</creator><scope>EVB</scope></search><sort><creationdate>20190503</creationdate><title>COMPOSITION COMPRISING SELF-ASSEMBLING PEPTIDES FOR USE IN TREATMENT OF GINGIVITIS, PERIODONTITIS AND/OR PERI-IMPLANTITIS</title><author>MEYER NINA ; BROESELER FRANK ; PIELES UWE ; JUNG RONALD ; LYSEK DOMINIKUS AMADEUS ; HAEMMERLE CHRISTOPH ; MATHES STEPHANIE ; HUG MICHAEL ; KOCH FRANZISKA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN109715193A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2019</creationdate><topic>CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES</topic><topic>DISINFECTION, STERILISATION, OR DEODORISATION OF AIR</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>MEYER NINA</creatorcontrib><creatorcontrib>BROESELER FRANK</creatorcontrib><creatorcontrib>PIELES UWE</creatorcontrib><creatorcontrib>JUNG RONALD</creatorcontrib><creatorcontrib>LYSEK DOMINIKUS AMADEUS</creatorcontrib><creatorcontrib>HAEMMERLE CHRISTOPH</creatorcontrib><creatorcontrib>MATHES STEPHANIE</creatorcontrib><creatorcontrib>HUG MICHAEL</creatorcontrib><creatorcontrib>KOCH FRANZISKA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MEYER NINA</au><au>BROESELER FRANK</au><au>PIELES UWE</au><au>JUNG RONALD</au><au>LYSEK DOMINIKUS AMADEUS</au><au>HAEMMERLE CHRISTOPH</au><au>MATHES STEPHANIE</au><au>HUG MICHAEL</au><au>KOCH FRANZISKA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPOSITION COMPRISING SELF-ASSEMBLING PEPTIDES FOR USE IN TREATMENT OF GINGIVITIS, PERIODONTITIS AND/OR PERI-IMPLANTITIS</title><date>2019-05-03</date><risdate>2019</risdate><abstract>The present invention provides a composition comprising specific self-assembling peptides, which are capable of self-assembly at a pH below 7.5 and at least physiologic ionic strength, e.g., PI 1-4. PI 1-8, PI 1-14, PI 1-13, PI 1-12, PI 1-28, PI 1-29, PI 1-2, PI 1-5, PI 1-17, PI 1-19, PI 1-20, PI 1-12, PI 1-16, PI 1-18, PI 1-26 or PI 1-31 for use in treating an oral disease selected from the groupconsisting of gingivitis, periodontitis and/or peri-implantitis in a subject. Said composition may be used, after suitable cleaning procedures, for filling pockets formed adjacent to teeth in said diseases, which enhances tissue regeneration. The composition may be suitable for controlled release of an active agent, e.g., an antimicrobial or antibiotic agent. The invention also provides a kit suitable for said treatment further comprising self-assembling peptides suitable for forming a second layer on top of the first composition.
本发明提供一种包含特定自组装肽的组合物，所述自组装肽能够在低于7.5的pH和至少生理离子强度下自组装，例如P11-4、P11-8、P11-14、P11-13、P11-12、P</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS |
| title | COMPOSITION COMPRISING SELF-ASSEMBLING PEPTIDES FOR USE IN TREATMENT OF GINGIVITIS, PERIODONTITIS AND/OR PERI-IMPLANTITIS |
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