New purpose of BK channel opener
The invention belongs to the biology field, and particularly relates to a new purpose of a BK channel opener. The BK channel opener is selected from one or combination of two kinds of NS1619 and BMS191011. Through detection of biochemical indicators after an animal model provides BK channel opener N...
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| creator | YU KE NING FENGLING ZHANG XUEMEI WANG YINXING XIN HONG WANG MENGLING |
| description | The invention belongs to the biology field, and particularly relates to a new purpose of a BK channel opener. The BK channel opener is selected from one or combination of two kinds of NS1619 and BMS191011. Through detection of biochemical indicators after an animal model provides BK channel opener NS1619 and BMS191011 intervention, and through in vitro cell research, experiment methods of proteinblot, data analysis and the like can show that the BK channel openers NS1619 and BMS191011 have the effect of restraining renal fibrosis, including the effect of restraining ECM accumulation, the effect of restraining a renal fibrosis marker from being generated, and the effect of restraining a TGF/Smad signal channel. The invention provides a theoretical basis for a mechanism of pharmacological action of restraining renal fibrosis and the like, and also establishes a test foundation for preparation of medicines for treating chronic kidney diseases, and has important significance.
本发明属于生物领域，尤其涉及BK通道开放剂的新用途。所述BK通道开放剂选自 |
| format | Patent |
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本发明属于生物领域，尤其涉及BK通道开放剂的新用途。所述BK通道开放剂选自</description><language>chi ; eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190503&DB=EPODOC&CC=CN&NR=109701024A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190503&DB=EPODOC&CC=CN&NR=109701024A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>YU KE</creatorcontrib><creatorcontrib>NING FENGLING</creatorcontrib><creatorcontrib>ZHANG XUEMEI</creatorcontrib><creatorcontrib>WANG YINXING</creatorcontrib><creatorcontrib>XIN HONG</creatorcontrib><creatorcontrib>WANG MENGLING</creatorcontrib><title>New purpose of BK channel opener</title><description>The invention belongs to the biology field, and particularly relates to a new purpose of a BK channel opener. The BK channel opener is selected from one or combination of two kinds of NS1619 and BMS191011. Through detection of biochemical indicators after an animal model provides BK channel opener NS1619 and BMS191011 intervention, and through in vitro cell research, experiment methods of proteinblot, data analysis and the like can show that the BK channel openers NS1619 and BMS191011 have the effect of restraining renal fibrosis, including the effect of restraining ECM accumulation, the effect of restraining a renal fibrosis marker from being generated, and the effect of restraining a TGF/Smad signal channel. The invention provides a theoretical basis for a mechanism of pharmacological action of restraining renal fibrosis and the like, and also establishes a test foundation for preparation of medicines for treating chronic kidney diseases, and has important significance.
本发明属于生物领域，尤其涉及BK通道开放剂的新用途。所述BK通道开放剂选自</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFDwSy1XKCgtKsgvTlXIT1Nw8lZIzkjMy0vNUcgvSM1LLeJhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJQFUl8c5-hgaW5gaGBkYmjsbEqAEAEJ8kkw</recordid><startdate>20190503</startdate><enddate>20190503</enddate><creator>YU KE</creator><creator>NING FENGLING</creator><creator>ZHANG XUEMEI</creator><creator>WANG YINXING</creator><creator>XIN HONG</creator><creator>WANG MENGLING</creator><scope>EVB</scope></search><sort><creationdate>20190503</creationdate><title>New purpose of BK channel opener</title><author>YU KE ; NING FENGLING ; ZHANG XUEMEI ; WANG YINXING ; XIN HONG ; WANG MENGLING</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN109701024A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2019</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>YU KE</creatorcontrib><creatorcontrib>NING FENGLING</creatorcontrib><creatorcontrib>ZHANG XUEMEI</creatorcontrib><creatorcontrib>WANG YINXING</creatorcontrib><creatorcontrib>XIN HONG</creatorcontrib><creatorcontrib>WANG MENGLING</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>YU KE</au><au>NING FENGLING</au><au>ZHANG XUEMEI</au><au>WANG YINXING</au><au>XIN HONG</au><au>WANG MENGLING</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>New purpose of BK channel opener</title><date>2019-05-03</date><risdate>2019</risdate><abstract>The invention belongs to the biology field, and particularly relates to a new purpose of a BK channel opener. The BK channel opener is selected from one or combination of two kinds of NS1619 and BMS191011. Through detection of biochemical indicators after an animal model provides BK channel opener NS1619 and BMS191011 intervention, and through in vitro cell research, experiment methods of proteinblot, data analysis and the like can show that the BK channel openers NS1619 and BMS191011 have the effect of restraining renal fibrosis, including the effect of restraining ECM accumulation, the effect of restraining a renal fibrosis marker from being generated, and the effect of restraining a TGF/Smad signal channel. The invention provides a theoretical basis for a mechanism of pharmacological action of restraining renal fibrosis and the like, and also establishes a test foundation for preparation of medicines for treating chronic kidney diseases, and has important significance.
本发明属于生物领域，尤其涉及BK通道开放剂的新用途。所述BK通道开放剂选自</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | New purpose of BK channel opener |
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