Photothermal responsive composite microneedle and preparation method thereof

Photothermal responsive composite microneedle and preparation method thereof

The invention discloses a photothermal responsive composite microneedle and a preparation method thereof. The preparation method comprises the steps: taking gelatin as a base, and grafting with methacrylic anhydride to prepare methylacrylated gelatin (GelMA); with GelMA as a template, a copper ammon...

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Hauptverfasser: LI YICHEN, LUO BICHONG, WANG XIAOYING
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Sprache:chi ; eng
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DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator LI YICHEN
LUO BICHONG
WANG XIAOYING
description The invention discloses a photothermal responsive composite microneedle and a preparation method thereof. The preparation method comprises the steps: taking gelatin as a base, and grafting with methacrylic anhydride to prepare methylacrylated gelatin (GelMA); with GelMA as a template, a copper ammonia solution as a copper source and sodium sulfide as a sulfur source, synthesizing copper sulfide nanoparticles at room temperature; adding N-isopropylacrylamide, introducing into a polydimethylsiloxane template obtained by remoulding, and photocross-linking and curing under ultraviolet light, to obtain the responsive composite microneedle material that can respond to light and heat and release drugs in skin. The composite microneedle not only easily punctures the skin layer, can respond to light and heat to deliver drugs on demand, but also has good biocompatibility. At the same time, the preparation process of copper sulfide nanoparticles is simple and easy to implement, avoids the use ofsurfactants and the like,
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The preparation method comprises the steps: taking gelatin as a base, and grafting with methacrylic anhydride to prepare methylacrylated gelatin (GelMA); with GelMA as a template, a copper ammonia solution as a copper source and sodium sulfide as a sulfur source, synthesizing copper sulfide nanoparticles at room temperature; adding N-isopropylacrylamide, introducing into a polydimethylsiloxane template obtained by remoulding, and photocross-linking and curing under ultraviolet light, to obtain the responsive composite microneedle material that can respond to light and heat and release drugs in skin. The composite microneedle not only easily punctures the skin layer, can respond to light and heat to deliver drugs on demand, but also has good biocompatibility. 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subjects DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Photothermal responsive composite microneedle and preparation method thereof
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