Pyrrolidine derivative serving as PPAR agonist
The present invention discloses a class of pyrrolidine derivatives as PPAR agonist, and their use for the treatment of some diseases of PPAR receptor-associated pathways (such as nonalcoholic steatohepatitis and concurrent fibrosis, insulin resistance, primary biliary cholgangitis, dyslipidenmia, hy...
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| creator | JIANG ZHIGAN LIU ZHIQIANG LONG CHAOFENG HE HAIYING GAO LEILEI YUAN ZHINAI LI JIAN ZHANG XIAO GONG ZHEN CHEN SHUHUI CHEN XIAOXIN LIU XING WANG YAN |
| description | The present invention discloses a class of pyrrolidine derivatives as PPAR agonist, and their use for the treatment of some diseases of PPAR receptor-associated pathways (such as nonalcoholic steatohepatitis and concurrent fibrosis, insulin resistance, primary biliary cholgangitis, dyslipidenmia, hyperlipidemia, hypercholesterolemia, atherosclerosis, hypertriglyceridemia, cardiovascular disease, obesity or the like). In particular, the present invention discloses a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof.
本发明公开了类作为PPAR激动剂的吡咯烷衍生物，及其在治疗PPAR受体相关通路的些疾病(比如非酒精性脂肪性肝炎及并发纤维化、胰岛素抵抗、原发性胆汁性胆管炎、血脂异常症、高脂血症、高胆固醇血症、动脉粥样硬化、高甘油三酯血症、心血管疾病、肥胖症等)中的应用。具体公开了式(I)所示化合物或其药学上可接受的盐。 |
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本发明公开了类作为PPAR激动剂的吡咯烷衍生物，及其在治疗PPAR受体相关通路的些疾病(比如非酒精性脂肪性肝炎及并发纤维化、胰岛素抵抗、原发性胆汁性胆管炎、血脂异常症、高脂血症、高胆固醇血症、动脉粥样硬化、高甘油三酯血症、心血管疾病、肥胖症等)中的应用。具体公开了式(I)所示化合物或其药学上可接受的盐。</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190402&DB=EPODOC&CC=CN&NR=109563032A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190402&DB=EPODOC&CC=CN&NR=109563032A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JIANG ZHIGAN</creatorcontrib><creatorcontrib>LIU ZHIQIANG</creatorcontrib><creatorcontrib>LONG CHAOFENG</creatorcontrib><creatorcontrib>HE HAIYING</creatorcontrib><creatorcontrib>GAO LEILEI</creatorcontrib><creatorcontrib>YUAN ZHINAI</creatorcontrib><creatorcontrib>LI JIAN</creatorcontrib><creatorcontrib>ZHANG XIAO</creatorcontrib><creatorcontrib>GONG ZHEN</creatorcontrib><creatorcontrib>CHEN SHUHUI</creatorcontrib><creatorcontrib>CHEN XIAOXIN</creatorcontrib><creatorcontrib>LIU XING</creatorcontrib><creatorcontrib>WANG YAN</creatorcontrib><title>Pyrrolidine derivative serving as PPAR agonist</title><description>The present invention discloses a class of pyrrolidine derivatives as PPAR agonist, and their use for the treatment of some diseases of PPAR receptor-associated pathways (such as nonalcoholic steatohepatitis and concurrent fibrosis, insulin resistance, primary biliary cholgangitis, dyslipidenmia, hyperlipidemia, hypercholesterolemia, atherosclerosis, hypertriglyceridemia, cardiovascular disease, obesity or the like). In particular, the present invention discloses a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof.
本发明公开了类作为PPAR激动剂的吡咯烷衍生物，及其在治疗PPAR受体相关通路的些疾病(比如非酒精性脂肪性肝炎及并发纤维化、胰岛素抵抗、原发性胆汁性胆管炎、血脂异常症、高脂血症、高胆固醇血症、动脉粥样硬化、高甘油三酯血症、心血管疾病、肥胖症等)中的应用。具体公开了式(I)所示化合物或其药学上可接受的盐。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNALqCwqys_JTMnMS1VISS3KLEssySxLVShOLSrLzEtXSCxWCAhwDFJITM_Pyywu4WFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8c5-hgaWpmbGBsZGjsbEqAEA-_oqbQ</recordid><startdate>20190402</startdate><enddate>20190402</enddate><creator>JIANG ZHIGAN</creator><creator>LIU ZHIQIANG</creator><creator>LONG CHAOFENG</creator><creator>HE HAIYING</creator><creator>GAO LEILEI</creator><creator>YUAN ZHINAI</creator><creator>LI JIAN</creator><creator>ZHANG XIAO</creator><creator>GONG ZHEN</creator><creator>CHEN SHUHUI</creator><creator>CHEN XIAOXIN</creator><creator>LIU XING</creator><creator>WANG YAN</creator><scope>EVB</scope></search><sort><creationdate>20190402</creationdate><title>Pyrrolidine derivative serving as PPAR agonist</title><author>JIANG ZHIGAN ; LIU ZHIQIANG ; LONG CHAOFENG ; HE HAIYING ; GAO LEILEI ; YUAN ZHINAI ; LI JIAN ; ZHANG XIAO ; GONG ZHEN ; CHEN SHUHUI ; CHEN XIAOXIN ; LIU XING ; WANG YAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN109563032A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2019</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>JIANG ZHIGAN</creatorcontrib><creatorcontrib>LIU ZHIQIANG</creatorcontrib><creatorcontrib>LONG CHAOFENG</creatorcontrib><creatorcontrib>HE HAIYING</creatorcontrib><creatorcontrib>GAO LEILEI</creatorcontrib><creatorcontrib>YUAN ZHINAI</creatorcontrib><creatorcontrib>LI JIAN</creatorcontrib><creatorcontrib>ZHANG XIAO</creatorcontrib><creatorcontrib>GONG ZHEN</creatorcontrib><creatorcontrib>CHEN SHUHUI</creatorcontrib><creatorcontrib>CHEN XIAOXIN</creatorcontrib><creatorcontrib>LIU XING</creatorcontrib><creatorcontrib>WANG YAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JIANG ZHIGAN</au><au>LIU ZHIQIANG</au><au>LONG CHAOFENG</au><au>HE HAIYING</au><au>GAO LEILEI</au><au>YUAN ZHINAI</au><au>LI JIAN</au><au>ZHANG XIAO</au><au>GONG ZHEN</au><au>CHEN SHUHUI</au><au>CHEN XIAOXIN</au><au>LIU XING</au><au>WANG YAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Pyrrolidine derivative serving as PPAR agonist</title><date>2019-04-02</date><risdate>2019</risdate><abstract>The present invention discloses a class of pyrrolidine derivatives as PPAR agonist, and their use for the treatment of some diseases of PPAR receptor-associated pathways (such as nonalcoholic steatohepatitis and concurrent fibrosis, insulin resistance, primary biliary cholgangitis, dyslipidenmia, hyperlipidemia, hypercholesterolemia, atherosclerosis, hypertriglyceridemia, cardiovascular disease, obesity or the like). In particular, the present invention discloses a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof.
本发明公开了类作为PPAR激动剂的吡咯烷衍生物，及其在治疗PPAR受体相关通路的些疾病(比如非酒精性脂肪性肝炎及并发纤维化、胰岛素抵抗、原发性胆汁性胆管炎、血脂异常症、高脂血症、高胆固醇血症、动脉粥样硬化、高甘油三酯血症、心血管疾病、肥胖症等)中的应用。具体公开了式(I)所示化合物或其药学上可接受的盐。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Pyrrolidine derivative serving as PPAR agonist |
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