N-(3-((4-trifluoromethyl)-2-pyrimidinyl)aminophenyl)-2,6-difluorobenzene sulfamide derivative
The invention discloses N-(3-((4-trifluoromethyl)-2-pyrimidinyl)aminophenyl)-2,6-difluorobenzene sulfamide having an anti-tumor activity and a derivative thereof, and synthesis methods thereof. The N-(3-((4-trifluoromethyl)-2-pyrimidinyl)aminophenyl)-2,6-difluorobenzene sulfamide has a structural fo...
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| creator | ZHU XIAOFENG ZHANG YUQI LUO ZHONGFENG DENG RONG ZENG ZHUO XIA ZHENGCE FENG GONGKAN WANG HUI |
| description | The invention discloses N-(3-((4-trifluoromethyl)-2-pyrimidinyl)aminophenyl)-2,6-difluorobenzene sulfamide having an anti-tumor activity and a derivative thereof, and synthesis methods thereof. The N-(3-((4-trifluoromethyl)-2-pyrimidinyl)aminophenyl)-2,6-difluorobenzene sulfamide has a structural formula as shown in Formula I. The synthesis method disclosed by the invention comprises the followingsteps: performing nucleophilic substitution on 2,6-difluorobenzenesulfonyl chloride and m-phenylenediamine to obtain sulfonamide; enabling an amino group of N-(3-aminophenyl)-2,6-difluorobenzene sulfamide to react with cyanamide to obtain guanidine salt; then preparing a series of different substituted 1,3-diketone compounds; finally, enabling the guanidine salt to react with 1,3-diketone to forma pyrimidine ring, and ingeniously introducing the anactive group of the pyrimidine ring into a molecular structure. According to the N-(3-((4-trifluoromethyl)-2-pyrimidinyl)aminophenyl)-2,6-difluorobenzene sulfamide and the |
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The N-(3-((4-trifluoromethyl)-2-pyrimidinyl)aminophenyl)-2,6-difluorobenzene sulfamide has a structural formula as shown in Formula I. The synthesis method disclosed by the invention comprises the followingsteps: performing nucleophilic substitution on 2,6-difluorobenzenesulfonyl chloride and m-phenylenediamine to obtain sulfonamide; enabling an amino group of N-(3-aminophenyl)-2,6-difluorobenzene sulfamide to react with cyanamide to obtain guanidine salt; then preparing a series of different substituted 1,3-diketone compounds; finally, enabling the guanidine salt to react with 1,3-diketone to forma pyrimidine ring, and ingeniously introducing the anactive group of the pyrimidine ring into a molecular structure. According to the N-(3-((4-trifluoromethyl)-2-pyrimidinyl)aminophenyl)-2,6-difluorobenzene sulfamide and the</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190308&DB=EPODOC&CC=CN&NR=109438365A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190308&DB=EPODOC&CC=CN&NR=109438365A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZHU XIAOFENG</creatorcontrib><creatorcontrib>ZHANG YUQI</creatorcontrib><creatorcontrib>LUO ZHONGFENG</creatorcontrib><creatorcontrib>DENG RONG</creatorcontrib><creatorcontrib>ZENG ZHUO</creatorcontrib><creatorcontrib>XIA ZHENGCE</creatorcontrib><creatorcontrib>FENG GONGKAN</creatorcontrib><creatorcontrib>WANG HUI</creatorcontrib><title>N-(3-((4-trifluoromethyl)-2-pyrimidinyl)aminophenyl)-2,6-difluorobenzene sulfamide derivative</title><description>The invention discloses N-(3-((4-trifluoromethyl)-2-pyrimidinyl)aminophenyl)-2,6-difluorobenzene sulfamide having an anti-tumor activity and a derivative thereof, and synthesis methods thereof. The N-(3-((4-trifluoromethyl)-2-pyrimidinyl)aminophenyl)-2,6-difluorobenzene sulfamide has a structural formula as shown in Formula I. The synthesis method disclosed by the invention comprises the followingsteps: performing nucleophilic substitution on 2,6-difluorobenzenesulfonyl chloride and m-phenylenediamine to obtain sulfonamide; enabling an amino group of N-(3-aminophenyl)-2,6-difluorobenzene sulfamide to react with cyanamide to obtain guanidine salt; then preparing a series of different substituted 1,3-diketone compounds; finally, enabling the guanidine salt to react with 1,3-diketone to forma pyrimidine ring, and ingeniously introducing the anactive group of the pyrimidine ring into a molecular structure. 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The N-(3-((4-trifluoromethyl)-2-pyrimidinyl)aminophenyl)-2,6-difluorobenzene sulfamide has a structural formula as shown in Formula I. The synthesis method disclosed by the invention comprises the followingsteps: performing nucleophilic substitution on 2,6-difluorobenzenesulfonyl chloride and m-phenylenediamine to obtain sulfonamide; enabling an amino group of N-(3-aminophenyl)-2,6-difluorobenzene sulfamide to react with cyanamide to obtain guanidine salt; then preparing a series of different substituted 1,3-diketone compounds; finally, enabling the guanidine salt to react with 1,3-diketone to forma pyrimidine ring, and ingeniously introducing the anactive group of the pyrimidine ring into a molecular structure. According to the N-(3-((4-trifluoromethyl)-2-pyrimidinyl)aminophenyl)-2,6-difluorobenzene sulfamide and the</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | N-(3-((4-trifluoromethyl)-2-pyrimidinyl)aminophenyl)-2,6-difluorobenzene sulfamide derivative |
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