Sulfur-containing shikonin oxime derivative and uses thereof

The invention provides a sulfur-containing shikonin oxime derivative and uses thereof, wherein the structural general formula is represented by a formula (I), the wavy line in the formula is defined in the specification, R is R or COR , R is C1-C16 alkane, olefin, aromatic hydrocarbon or substituted aromatic hydrocarbon, and R is C1-C6 alkane, olefin, aromatic hydrocarbon or substitutedaromatic hydrocarbon. According to the present invention, the preparation method is simple, and the yield is high; and the in vitro antitumor results show that the compound has good antitumor activity, and can well resist the drug resistance of tumors, the good biocompatibility can be achieved by introducing the sulfur atom, and the antitumor activity can be improved. 本发明提供了种含硫紫草素肟衍生物及其用途，结构通式如式(I)所示：其中为-，或R为R或COR；所述R为碳原子长度为1～16的烷烃、烯烃、芳香烃或取代芳香烃，R为碳原子长度为1～6的烷烃、烯烃、芳香烃或取代芳香烃。本发明的含硫紫草素肟衍生物的制备方法简便，产率较高；体外抗肿瘤结果显示，该类化合物具有均显示较好的抗肿瘤活性和抗肿瘤耐药活性，硫原子的引入具有更好的生物相容性，能提高抗肿瘤活性。