Preparation method and application of vitamin E polyethylene glycol disuccinate

The invention discloses a preparation method of vitamin E polyethylene glycol disuccinate and application of the vitamin E polyethylene glycol disuccinate, and belongs to the technical field of synthesis. The method comprises the steps that after vitamin E succinate and polyethylene glycol are mixed, heated and molten, an acid catalyst is added, under a vacuum condition, at 50-150 DEG C, reactionis carried out, after the reaction is carried out, a solvent is added for dissolution, an alkaline solution is added for neutralization and extraction, an adsorbent is added for adsorption, filteringis conducted, and the solvent is vaporized to obtain the vitamin E polyethylene glycol disuccinate; a molar ratio of the vitamin E succinate to the polyethylene glycol is (2 to 3) to 1. According to the method, a simple technology is used for directly synthesizing di-esterization TPGS, and the content of the di-esterization TPGS obtained through the method can be up to 98% or above. By adding thevitamin E polyethylene glyc