Cephalosporin salts and process for the preparation thereof

The invention relates to cephalosporin salts of the general formula (I), [cephalosporin]x[BxH]n (I> in which the salt-forming anion contains an antibiotically active cephalosporin having a group (m = 1) which is capable of anion formation, or having several groups of this nature (m = 2 or 3), and...

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Bibliographische Detailangaben
Hauptverfasser: WALTER DUERCKHEIMER, DIETER ISERT, ROBERT RIPPEL
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention relates to cephalosporin salts of the general formula (I), [cephalosporin]x[BxH]n (I> in which the salt-forming anion contains an antibiotically active cephalosporin having a group (m = 1) which is capable of anion formation, or having several groups of this nature (m = 2 or 3), and the base, which can be present as a pure (+) or (-) enantiomer or in racemic form, possesses the general formula (B), R is straight-chain or branched alkyl having 1-8 C atoms which is optionally substituted by hydroxyl or phenyl or by phenyl which is substituted by alkoxy or halogen; preferably is a methyl, ethyl, propyl, butyl or benzyl group, R , R , R and R can be identical or different and be hydrogen or straight-chain or branched alkyl having 1-4 C atoms, R preferably being propyl, R and R preferably being methyl, and R preferably being hydrogen, and m and n depending on the number of salt-forming groups in the cephalosporin moiety, have a number of from 1 to 3 for m, preferably 1 and 2, and for n 0.1 to 3, preferably 0.1 to 2. The cephalosporin salts according to the invention possess very good antibacterial activity and can therefore be used as drugs (medicaments, pharmaceuticals, medicines).