Applications of triterpenoid saponin compound in preparing products for treating triple negative breast cancer

The invention relates to applications of a triterpenoid saponin compound with the activity of resisting breast cancer, namely, 3beta-O-{alpha-L-rhamnopyranosyl-(1->3)-[bata-D-glucopyranosyl-(1->3)-beta-D-xylopyranosyl-(1->2)]-beta-D-glucopyranosyl-(1->4)-[beta-D- glucopyranosyl-(1->2)...

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Bibliographische Detailangaben
Hauptverfasser: MU LIHUA, LIU PING, HU YUAN, DONG XIANZHE, LIU XU, ZHANG JING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to applications of a triterpenoid saponin compound with the activity of resisting breast cancer, namely, 3beta-O-{alpha-L-rhamnopyranosyl-(1->3)-[bata-D-glucopyranosyl-(1->3)-beta-D-xylopyranosyl-(1->2)]-beta-D-glucopyranosyl-(1->4)-[beta-D- glucopyranosyl-(1->2)]-alpha-L-arabinopyranosyl}-16alpha-hydroxy-13,28-epoxy-oleanane in preparing medicines for treating triple negative breast cancer diseases. The compound has the obvious effect of inhibiting proliferation of MCF-7, T47D, MDA-MB-231 and SK-BR-3 in vitro, and especially has the obvious selective inhibiting effect for triple negative breast cancer MDA-MB-231 cells. The MDA-MB-231 tumor-bearing nude mouse experiment proves that the compound can obviously inhibit the growth of tumor. 本发明涉及具有抗乳腺癌活性的三萜皂苷类化合物3β-O-{α-L-吡喃鼠李糖基-(13)-[β-D-吡喃葡萄糖基-(13)-β-D-吡喃木糖基-(12)]-β-D-吡喃葡萄糖基-(14)-[β-D-吡喃葡萄糖基-(12)]-α-L-吡喃阿拉伯糖基}-16α-羟基-13,28-环氧-齐墩果烷在制备治疗三阴性乳腺癌疾病药物的用途。该化合物在体外具有明显的抑制MCF-7,T47D,MDA-MB-231和SK-BR-3增殖的作用,尤其是对三阴性乳腺癌MDA-MB-231细胞有显著的选择性抑制作用。MDA-MB-23