CYCLODEXTRIN BASED POLYMERS, METHODS, COMPOSITIONS AND APPLICATIONS THEREOF
The present disclosure relates to polymers comprising conjugates of cyclodextrin or derivatives thereof and a linker moiety, methods of preparing the same and their application in the removal of lipids such as cholesterol from cells in treating lipid storage disorders. The present polymers exhibit i...
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| creator | KHURANA PRINCY KULKARNI ADITYA MANJUNATH MANU DOLAS ATUL JOHNY SONIYA |
| description | The present disclosure relates to polymers comprising conjugates of cyclodextrin or derivatives thereof and a linker moiety, methods of preparing the same and their application in the removal of lipids such as cholesterol from cells in treating lipid storage disorders. The present polymers exhibit improved properties including but not limiting to improved biocompatibility, improved retention time,prolonged duration of action in cells, and increased efficacy in removal of cholesterol from cells in treating lipid storage disorders.
本公开涉及包含环糊精缀合物或其衍生物和接头部分的聚合物，制备该聚合物的方法和它们在治疗脂质贮积症中从细胞移除脂质如胆固醇中的应用。本发明的聚合物显示出改善的性质，其包括(但不限于)改善的生物相容性、改善的保留时间、细胞中延长的持续作用时间和在治疗脂质贮积症中提高的从细胞移除胆固醇的效力。 |
| format | Patent |
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本公开涉及包含环糊精缀合物或其衍生物和接头部分的聚合物，制备该聚合物的方法和它们在治疗脂质贮积症中从细胞移除脂质如胆固醇中的应用。本发明的聚合物显示出改善的性质，其包括(但不限于)改善的生物相容性、改善的保留时间、细胞中延长的持续作用时间和在治疗脂质贮积症中提高的从细胞移除胆固醇的效力。</description><language>chi ; eng</language><subject>CHEMISTRY ; COMPOSITIONS BASED THEREON ; DERIVATIVES THEREOF ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC MACROMOLECULAR COMPOUNDS ; POLYSACCHARIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190104&DB=EPODOC&CC=CN&NR=109153735A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190104&DB=EPODOC&CC=CN&NR=109153735A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KHURANA PRINCY</creatorcontrib><creatorcontrib>KULKARNI ADITYA</creatorcontrib><creatorcontrib>MANJUNATH MANU</creatorcontrib><creatorcontrib>DOLAS ATUL</creatorcontrib><creatorcontrib>JOHNY SONIYA</creatorcontrib><title>CYCLODEXTRIN BASED POLYMERS, METHODS, COMPOSITIONS AND APPLICATIONS THEREOF</title><description>The present disclosure relates to polymers comprising conjugates of cyclodextrin or derivatives thereof and a linker moiety, methods of preparing the same and their application in the removal of lipids such as cholesterol from cells in treating lipid storage disorders. The present polymers exhibit improved properties including but not limiting to improved biocompatibility, improved retention time,prolonged duration of action in cells, and increased efficacy in removal of cholesterol from cells in treating lipid storage disorders.
本公开涉及包含环糊精缀合物或其衍生物和接头部分的聚合物，制备该聚合物的方法和它们在治疗脂质贮积症中从细胞移除脂质如胆固醇中的应用。本发明的聚合物显示出改善的性质，其包括(但不限于)改善的生物相容性、改善的保留时间、细胞中延长的持续作用时间和在治疗脂质贮积症中提高的从细胞移除胆固醇的效力。</description><subject>CHEMISTRY</subject><subject>COMPOSITIONS BASED THEREON</subject><subject>DERIVATIVES THEREOF</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC MACROMOLECULAR COMPOUNDS</subject><subject>POLYSACCHARIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPB2jnT28XdxjQgJ8vRTcHIMdnVRCPD3ifR1DQrWUfB1DfHwdwEynP19A_yDPUM8_f2CFRz9XBQcAwJ8PJ0dIQIhHq5Brv5uPAysaYk5xam8UJqbQdHNNcTZQze1ID8-tbggMTk1L7Uk3tnP0MDS0NTY3NjU0ZgYNQC4Ai4C</recordid><startdate>20190104</startdate><enddate>20190104</enddate><creator>KHURANA PRINCY</creator><creator>KULKARNI ADITYA</creator><creator>MANJUNATH MANU</creator><creator>DOLAS ATUL</creator><creator>JOHNY SONIYA</creator><scope>EVB</scope></search><sort><creationdate>20190104</creationdate><title>CYCLODEXTRIN BASED POLYMERS, METHODS, COMPOSITIONS AND APPLICATIONS THEREOF</title><author>KHURANA PRINCY ; KULKARNI ADITYA ; MANJUNATH MANU ; DOLAS ATUL ; JOHNY SONIYA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN109153735A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2019</creationdate><topic>CHEMISTRY</topic><topic>COMPOSITIONS BASED THEREON</topic><topic>DERIVATIVES THEREOF</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC MACROMOLECULAR COMPOUNDS</topic><topic>POLYSACCHARIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>THEIR PREPARATION OR CHEMICAL WORKING-UP</topic><toplevel>online_resources</toplevel><creatorcontrib>KHURANA PRINCY</creatorcontrib><creatorcontrib>KULKARNI ADITYA</creatorcontrib><creatorcontrib>MANJUNATH MANU</creatorcontrib><creatorcontrib>DOLAS ATUL</creatorcontrib><creatorcontrib>JOHNY SONIYA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KHURANA PRINCY</au><au>KULKARNI ADITYA</au><au>MANJUNATH MANU</au><au>DOLAS ATUL</au><au>JOHNY SONIYA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CYCLODEXTRIN BASED POLYMERS, METHODS, COMPOSITIONS AND APPLICATIONS THEREOF</title><date>2019-01-04</date><risdate>2019</risdate><abstract>The present disclosure relates to polymers comprising conjugates of cyclodextrin or derivatives thereof and a linker moiety, methods of preparing the same and their application in the removal of lipids such as cholesterol from cells in treating lipid storage disorders. The present polymers exhibit improved properties including but not limiting to improved biocompatibility, improved retention time,prolonged duration of action in cells, and increased efficacy in removal of cholesterol from cells in treating lipid storage disorders.
本公开涉及包含环糊精缀合物或其衍生物和接头部分的聚合物，制备该聚合物的方法和它们在治疗脂质贮积症中从细胞移除脂质如胆固醇中的应用。本发明的聚合物显示出改善的性质，其包括(但不限于)改善的生物相容性、改善的保留时间、细胞中延长的持续作用时间和在治疗脂质贮积症中提高的从细胞移除胆固醇的效力。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY COMPOSITIONS BASED THEREON DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR PREPARATION OR CHEMICAL WORKING-UP |
| title | CYCLODEXTRIN BASED POLYMERS, METHODS, COMPOSITIONS AND APPLICATIONS THEREOF |
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