PH responsive polymer carrier, micelle prepared from same, preparation method and application
The invention discloses a pH responsive polymer carrier, micelle prepared from the same, a preparation method and application. The pH responsive polymer carrier is formed by self-assembling diblock copolymer A and diblock copolymer B in an aqueous solution; the diblock copolymer A is PDEAEMA-PPEGMA,...
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| creator | LIN JIAYU GUO JIANWEI YANG CHUFEN LIN WENJING XIAO JIAYU |
| description | The invention discloses a pH responsive polymer carrier, micelle prepared from the same, a preparation method and application. The pH responsive polymer carrier is formed by self-assembling diblock copolymer A and diblock copolymer B in an aqueous solution; the diblock copolymer A is PDEAEMA-PPEGMA, and the structure is as shown in the formula (I); the diblock copolymer B is PCL-PPEGMA, and the structure is as shown in the formula (II); y is a positive integer from 20 to 35, n is a positive integer from 10 to 30, x is a positive integer from 50 to 70, and m is a positive integer from 5 o 25. Accordingly, the pH responsive polymer mutual compatibility is good, the carrier drug loading capacity is high, the CMC is low, the pH controlled release performance is good, pH responsive polymers canexist stably for a long time under the neutral condition, and the drug release amount is low; under the acidic condition, drugs are subjected to slow controlled release, and then drug target positioning control release is ac |
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The pH responsive polymer carrier is formed by self-assembling diblock copolymer A and diblock copolymer B in an aqueous solution; the diblock copolymer A is PDEAEMA-PPEGMA, and the structure is as shown in the formula (I); the diblock copolymer B is PCL-PPEGMA, and the structure is as shown in the formula (II); y is a positive integer from 20 to 35, n is a positive integer from 10 to 30, x is a positive integer from 50 to 70, and m is a positive integer from 5 o 25. Accordingly, the pH responsive polymer mutual compatibility is good, the carrier drug loading capacity is high, the CMC is low, the pH controlled release performance is good, pH responsive polymers canexist stably for a long time under the neutral condition, and the drug release amount is low; under the acidic condition, drugs are subjected to slow controlled release, and then drug target positioning control release is ac</description><language>chi ; eng</language><subject>CHEMISTRY ; COMPOSITIONS BASED THEREON ; HUMAN NECESSITIES ; HYGIENE ; MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS ; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC MACROMOLECULAR COMPOUNDS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190104&DB=EPODOC&CC=CN&NR=109134870A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190104&DB=EPODOC&CC=CN&NR=109134870A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LIN JIAYU</creatorcontrib><creatorcontrib>GUO JIANWEI</creatorcontrib><creatorcontrib>YANG CHUFEN</creatorcontrib><creatorcontrib>LIN WENJING</creatorcontrib><creatorcontrib>XIAO JIAYU</creatorcontrib><title>PH responsive polymer carrier, micelle prepared from same, preparation method and application</title><description>The invention discloses a pH responsive polymer carrier, micelle prepared from the same, a preparation method and application. The pH responsive polymer carrier is formed by self-assembling diblock copolymer A and diblock copolymer B in an aqueous solution; the diblock copolymer A is PDEAEMA-PPEGMA, and the structure is as shown in the formula (I); the diblock copolymer B is PCL-PPEGMA, and the structure is as shown in the formula (II); y is a positive integer from 20 to 35, n is a positive integer from 10 to 30, x is a positive integer from 50 to 70, and m is a positive integer from 5 o 25. Accordingly, the pH responsive polymer mutual compatibility is good, the carrier drug loading capacity is high, the CMC is low, the pH controlled release performance is good, pH responsive polymers canexist stably for a long time under the neutral condition, and the drug release amount is low; under the acidic condition, drugs are subjected to slow controlled release, and then drug target positioning control release is ac</description><subject>CHEMISTRY</subject><subject>COMPOSITIONS BASED THEREON</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS</subject><subject>MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC MACROMOLECULAR COMPOUNDS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjbsKwkAURLexEPUfrn2EhAhqKUFJJRa2Ei6bCS7si7uL4N-7SD7AYhg4Z2CW6nnvSZBi8Mm8QTHYj4OQZhEDqcgZDWuLEEQWjDRJcJTYoZoZZxM8OeRXGIl9SYzW6B9eq8XENmEz90ptr5dH1-8Qw1BeWcMjD92tqU9Nuz8e6nP7z-YL-1w8SQ</recordid><startdate>20190104</startdate><enddate>20190104</enddate><creator>LIN JIAYU</creator><creator>GUO JIANWEI</creator><creator>YANG CHUFEN</creator><creator>LIN WENJING</creator><creator>XIAO JIAYU</creator><scope>EVB</scope></search><sort><creationdate>20190104</creationdate><title>PH responsive polymer carrier, micelle prepared from same, preparation method and application</title><author>LIN JIAYU ; GUO JIANWEI ; YANG CHUFEN ; LIN WENJING ; XIAO JIAYU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN109134870A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2019</creationdate><topic>CHEMISTRY</topic><topic>COMPOSITIONS BASED THEREON</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS</topic><topic>MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC MACROMOLECULAR COMPOUNDS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>THEIR PREPARATION OR CHEMICAL WORKING-UP</topic><toplevel>online_resources</toplevel><creatorcontrib>LIN JIAYU</creatorcontrib><creatorcontrib>GUO JIANWEI</creatorcontrib><creatorcontrib>YANG CHUFEN</creatorcontrib><creatorcontrib>LIN WENJING</creatorcontrib><creatorcontrib>XIAO JIAYU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LIN JIAYU</au><au>GUO JIANWEI</au><au>YANG CHUFEN</au><au>LIN WENJING</au><au>XIAO JIAYU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PH responsive polymer carrier, micelle prepared from same, preparation method and application</title><date>2019-01-04</date><risdate>2019</risdate><abstract>The invention discloses a pH responsive polymer carrier, micelle prepared from the same, a preparation method and application. The pH responsive polymer carrier is formed by self-assembling diblock copolymer A and diblock copolymer B in an aqueous solution; the diblock copolymer A is PDEAEMA-PPEGMA, and the structure is as shown in the formula (I); the diblock copolymer B is PCL-PPEGMA, and the structure is as shown in the formula (II); y is a positive integer from 20 to 35, n is a positive integer from 10 to 30, x is a positive integer from 50 to 70, and m is a positive integer from 5 o 25. Accordingly, the pH responsive polymer mutual compatibility is good, the carrier drug loading capacity is high, the CMC is low, the pH controlled release performance is good, pH responsive polymers canexist stably for a long time under the neutral condition, and the drug release amount is low; under the acidic condition, drugs are subjected to slow controlled release, and then drug target positioning control release is ac</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY COMPOSITIONS BASED THEREON HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR CHEMICAL WORKING-UP |
| title | PH responsive polymer carrier, micelle prepared from same, preparation method and application |
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