Salt of 5-fluorouracil and metformin as well as preparation method and crystal structure of salt

Salt of 5-fluorouracil and metformin as well as preparation method and crystal structure of salt

The invention discloses a salt of 5-fluorouracil and metformin as well as a preparation method and a crystal structure of the salt and relates to the field of medicinal chemistry. The molecular formula of the 5-fluorouracil metformin salt is C8H14FN7O2; and a basic structural unit is formed by a met...

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Hauptverfasser: YAN CUIWEI, SONG YU, GUAN HUASHI, WU ZHIYONG, LIU FANG, LI YANTUAN, WANG LINGYANG
Format: Patent
Sprache:chi ; eng
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator YAN CUIWEI
SONG YU
GUAN HUASHI
WU ZHIYONG
LIU FANG
LI YANTUAN
WANG LINGYANG
description The invention discloses a salt of 5-fluorouracil and metformin as well as a preparation method and a crystal structure of the salt and relates to the field of medicinal chemistry. The molecular formula of the 5-fluorouracil metformin salt is C8H14FN7O2; and a basic structural unit is formed by a metformin anion and a 5-fluorouracil anion. The salt belongs to a monoclinic crystal system with a space group of P21/n. The preparation method comprises the following steps: taking a 5-fluorouracil crude drug and metformin free alkali as raw materials; mixing the 5-fluorouracil crude drug and the metformin free alkali according to the molar ratio of 1 to 1 and dissolving a mixture into a mixed solvent of methanol and acetonitrile for reacting; and taking ethanol as a solvent and recrystallizing toobtain high-purity 5-fluorouracil metformin salt. The 5-fluorouracil metformin salt disclosed by the invention has the advantages that the solubility of the 5-fluorouracil is improved and bioavailability of the 5-fluorouraci
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title Salt of 5-fluorouracil and metformin as well as preparation method and crystal structure of salt
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