Crystalline form of free base of imidazo isoindole derivative and preparation method therefor
The present invention relates to a crystalline form of a free base of an imidazo isoindole derivative and a preparation method therefor. Specifically, the present invention relates to the A, B, C, D,E, and F crystal forms of the compound represented by formula (I), the chemical name being (S)-2-(4-(...
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| creator | XIAO CHANGQIN DU ZHENXING WANG LIKUN CAO XIAOLI YOU LINGFENG |
| description | The present invention relates to a crystalline form of a free base of an imidazo isoindole derivative and a preparation method therefor. Specifically, the present invention relates to the A, B, C, D,E, and F crystal forms of the compound represented by formula (I), the chemical name being (S)-2-(4-(4-(4-(6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)piperidine-1-yl)phenyl)-1H-pyrazol-1-yl)ethanol. Thepresent invention also relates to a preparation method for the A, B, C, D, E, and F crystal forms, the use thereof in a pharmaceutical composition, and the uses of the A, B, C, D, E, and F crystal forms and the pharmaceutical composition in the treatment of diseases having an IDO-mediated tryptophan metabolic pathway pathological feature. The A, B, C, D, E, and F crystal forms of formula (I) obtained in the present invention have good stability, and the crystallisation solvent used has low toxicity and low residue, and the crystal forms can be better used for clinical treatment.
本发明涉及种咪唑并异吲哚类衍生物的游离碱的结晶形式及其制备方法。具体而言，本发明 |
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本发明涉及种咪唑并异吲哚类衍生物的游离碱的结晶形式及其制备方法。具体而言，本发明</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20181123&DB=EPODOC&CC=CN&NR=108884099A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20181123&DB=EPODOC&CC=CN&NR=108884099A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>XIAO CHANGQIN</creatorcontrib><creatorcontrib>DU ZHENXING</creatorcontrib><creatorcontrib>WANG LIKUN</creatorcontrib><creatorcontrib>CAO XIAOLI</creatorcontrib><creatorcontrib>YOU LINGFENG</creatorcontrib><title>Crystalline form of free base of imidazo isoindole derivative and preparation method therefor</title><description>The present invention relates to a crystalline form of a free base of an imidazo isoindole derivative and a preparation method therefor. Specifically, the present invention relates to the A, B, C, D,E, and F crystal forms of the compound represented by formula (I), the chemical name being (S)-2-(4-(4-(4-(6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)piperidine-1-yl)phenyl)-1H-pyrazol-1-yl)ethanol. Thepresent invention also relates to a preparation method for the A, B, C, D, E, and F crystal forms, the use thereof in a pharmaceutical composition, and the uses of the A, B, C, D, E, and F crystal forms and the pharmaceutical composition in the treatment of diseases having an IDO-mediated tryptophan metabolic pathway pathological feature. The A, B, C, D, E, and F crystal forms of formula (I) obtained in the present invention have good stability, and the crystallisation solvent used has low toxicity and low residue, and the crystal forms can be better used for clinical treatment.
本发明涉及种咪唑并异吲哚类衍生物的游离碱的结晶形式及其制备方法。具体而言，本发明</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjDEKwkAQRdNYiHqH8QBCRItYSlCsrGwljO5fMrDZWWaXgJ7eCB7A6vHg8ebVvbVXLhyCRJBXG0g9eQPowRlfkUEcv5Ukq0SnAeRgMnKREcTRUTIktsk10oDSq6PSwzDdltXMc8hY_bio1ufTrb1skLRDTvxEROna67ZummZfHw7H3T_NBxXuPKU</recordid><startdate>20181123</startdate><enddate>20181123</enddate><creator>XIAO CHANGQIN</creator><creator>DU ZHENXING</creator><creator>WANG LIKUN</creator><creator>CAO XIAOLI</creator><creator>YOU LINGFENG</creator><scope>EVB</scope></search><sort><creationdate>20181123</creationdate><title>Crystalline form of free base of imidazo isoindole derivative and preparation method therefor</title><author>XIAO CHANGQIN ; DU ZHENXING ; WANG LIKUN ; CAO XIAOLI ; YOU LINGFENG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN108884099A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2018</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>XIAO CHANGQIN</creatorcontrib><creatorcontrib>DU ZHENXING</creatorcontrib><creatorcontrib>WANG LIKUN</creatorcontrib><creatorcontrib>CAO XIAOLI</creatorcontrib><creatorcontrib>YOU LINGFENG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>XIAO CHANGQIN</au><au>DU ZHENXING</au><au>WANG LIKUN</au><au>CAO XIAOLI</au><au>YOU LINGFENG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Crystalline form of free base of imidazo isoindole derivative and preparation method therefor</title><date>2018-11-23</date><risdate>2018</risdate><abstract>The present invention relates to a crystalline form of a free base of an imidazo isoindole derivative and a preparation method therefor. Specifically, the present invention relates to the A, B, C, D,E, and F crystal forms of the compound represented by formula (I), the chemical name being (S)-2-(4-(4-(4-(6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)piperidine-1-yl)phenyl)-1H-pyrazol-1-yl)ethanol. Thepresent invention also relates to a preparation method for the A, B, C, D, E, and F crystal forms, the use thereof in a pharmaceutical composition, and the uses of the A, B, C, D, E, and F crystal forms and the pharmaceutical composition in the treatment of diseases having an IDO-mediated tryptophan metabolic pathway pathological feature. The A, B, C, D, E, and F crystal forms of formula (I) obtained in the present invention have good stability, and the crystallisation solvent used has low toxicity and low residue, and the crystal forms can be better used for clinical treatment.
本发明涉及种咪唑并异吲哚类衍生物的游离碱的结晶形式及其制备方法。具体而言，本发明</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Crystalline form of free base of imidazo isoindole derivative and preparation method therefor |
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